Exam 1

Question 1

drug that easily penetrates the blood-brain barrier to induce sleep within seconds after IV administration

Answer 1

thiopental

Question 2

besides the active ingredient, what doe elixirs contain

Answer 2

alcohol

Question 3

sugars can be found in what type of dosage form

Answer 3

syrup

Question 4

studies the MOA of drugs and seek how drugs work in body

Answer 4

pharmacodynamics

Question 5

a ____ is an inert substance given in place of a drug

Answer 5

placebo

Question 6

do ionize and unionized forms of drugs affect drug absorption?

Answer 6

yes

Question 7

what makes the membrane relatively impermeable to ions and polar molecules

Answer 7

membrane lipids

Question 8

these molecules form a bimolecular leaflet structure, list the 2 ends of each structure and briefly define each

Answer 8

hydrophobic: shield from h20
hydrophilic: come in contact w/ h2o

Question 9

overdose of acetaminophen can result in a major affect on which organ primarily

Answer 9

liver

Question 10

type of drugs readily moves across most biological membranes

Answer 10

highly lipid soluble

Question 11

name of common protein that drugs bind to

Answer 11

albumin and globulin

Question 12

oragan is major site for drug metabolims

Answer 12

liver

Question 13

oran most important in elimination of drug

Answer 13

kidney

Question 14

federal regulatory agency department of justice

Answer 14

DEA

Question 15

higher the potency of a drug the ____ the ED50

Answer 15

lower

Question 16

schedule of a drug that may be phoned in

Answer 16

III, IV

Question 17

schedule of drug that allows no refills and written Rx must have providers signature

Answer 17

II

Question 18

abuse potential for drug with class IV schedule of controlled substances

Answer 18

less

Question 19

tetracycline staining is considered to be what type of bond

Answer 19

covalent

Question 20

therapeutic index greater than ___ needed to produce therapeutically useful drug

Answer 20

10

Question 21

targets of a type I hypersensitivity are

Answer 21

bronchioles

Question 22

immunoglobulin assoc with type I reaction is

Answer 22

IgE

Question 23

immunoglobulin assoc with type II reaction

Answer 23

IgM or IgG

Question 24

very rapid development of tolerance within hours

Answer 24

tachyphylaxis

Question 25

how many mL in 1 fl oz

Answer 25

30

Question 26

immunoglobulin assoc with type iii reaction

Answer 26

IgG

Question 27

immunoglobulin assoc with type IV reaction

Answer 27

T lymphocytes and macrophages

Question 28

____ delivered drugs must pass through the hepatic portal circulation first. when this happens, what is the term for this

Answer 28

orally

first pass effect

Question 29

type of TI value would indicate high risk of toxicity

Answer 29

small (narrow) TI

Question 30

TI value would indicate low risk of toxicity

Answer 30

a large (wide) TI

Question 31

___tsp=1 tbsp

Answer 31

3

Question 32

therapeutic index of drug defined as

Answer 32

measure of toxicity of a drug

Question 33

rout of administration has quickest onset of action

Answer 33

IV