Exam 1 Flashcards
Physiology
the integrative study of the human body (major themes: organization, energy, information, interactions)
Homeostasis
the maintenance of a relatively constant, internal environment (Ex: pH, gases, ions, temp, fluids)
What do you need to regulate water temp?
thermostat-integrating center (detects water change)
heater-output signal (turn on heater)
water (increase in temp)
*original temp of water is input signal
What do you need to regulate glucose levels?
input signal : increase in glucose levels
integrating signal: pancreas detects change in glucose levels
output signal: pancreas releases insulin
response: decrease in glucose levels
Liver
Makes and stores glucose as glycogen (stops when glucose increases)
Negative Feedback
The response counteracts the stimulus, shutting off the response to the loop
Positive Feedback
An outside factor is required to shut off loop (Ex: child birth)
Plasma Cortisol
Detects stress levels
Cell membrane serves as
protection
structural support
regulation
communication
Inner Mitochondrial Membrane
High amount of protein to power the cell
Mylinated Nerve Cell
High amount of lipids to transmit signals
Red Blood Cell Membrane
Higher amount of carbs to detect blood type
Tissues
epithelial (simple, squamous, stratified, pseudostratified, cuboidal, columnar
connective
muscle
nerve
Histology
Study of tissues
Epithelial cells are
polarized
Apical
top
Basolateral
bottom
Lumen
opening
Connective Tissues
bone and cartilage
blood
adipose
loose connective tissue
dense regular connective tissue
Steady State
2 compartments where diff conc. are maintained (no net movement)
H and E
Hematoxylin and eosin (nuclei are stained blue/purple; proteins are stained pink)
ICF
2/3 of total body water volume (cells)
ECF
1/3 of total body water volume (interstitial fluid and blood plasma-lots of protein)
What proportion of the ECF is plasma?
25%
NaCl
1:1 b/c can dissociate
Glucose
1:1 b/c can’t dissociate
Aquaporin Channels
water channels and are open channels
ions cant get in due to size and charge
SD do not require proteins
carrier proteins open and close (FD and AT)
Active Transport
can move 1 or 2 substances
uniport (H+, ATPase)
symport (SGLT)-secondary
antiport (Na+/K+ ATPase)-primary
Saturation
Depend on conc, but has a limit
Competition
Glucose vs. glactose
Pinocytosis
Fluid intake
Phagocytosis
Solid intake
Autocrine Signal
Chemical
Gap Junction
Chemical and electrical
Hormones
Chemical
Neurohormone
Chemical
Neurotransmitters
Chemical and electrical
Paracrine Signal
Chemical
Ligand
Something that binds to a receptor
Intracellular Signal Receptors
gene exp.
ligands diffuse across cell
Lipophilic Molecules
Steroids
Target Cell Receptors
Rapid
G Protein
Coupled receptor (don’t cross membranes)
Second Messengers
Intracellular signals that amplify a signal (Ex: agonist and antagonist)
Tonic Control
Permits the activity of the organ system to be modulated, either up or down (Ex: diameter of a blood vessel; 1 factor)
Peptide Hormones
proteins (water soluable, cannot cross membrane)
amplify response (secondary messenger)
faster b/c extracellular (Ex: insulin)
Steroid Hormones
metabolizes (not water soluable, diffuse across membrane)
slower b/c intracellular (Ex: estrogen)
signal is within the cell (nucleus)–>transcription
Anterior Pituitary Gland
Endocrine gland (portal system)–> kidney and liver
Vessels
neurons (neurohormones)
endocrine cells (peptide hormones)–>prolactin, TSH, GH, ACTH, FH, LSH
Hypothalamic Hormones
Trophic (intermediate hormones that target other endocrine tissues)
Posterior Pituitary
oxytocin (childbirth)
vasopressin (ADH and BP)
Synergism
enhances effect
Antagonism
insulin (decreases BG)
glucogon (increases BG)
Permissivness
Thyroid hormone requires 2 factors w/ reprodutive hormones to have an effect
Primary Endocrine Pathology
Damage to adrenal cortex
Secondary Endocrine Pathology
Damage to an area upstream
Which cells are the most prominent in the body?
Epithelial and connective
How much of the ECF is interstitial fluid
75%
Facilitated Diffusion
ions
small polar molecules
large polar molecules
Hormones
Secreted by endocrine glands or cells into the blood
Osmolarity
Decribes the number of particles in the solution (solute/volume)
Tonicity
Describes the solution and how the extracellular solution would affect cell volume
Law of Mass Balance
existing body load (body load)
intake of metabolic production (input)
excretion of metabolic removal (output)
dynamic equalibrium
Materials that are constantly moving back and forth to maintain homeostasis
3 classes of molecules that make up cell membrane
proteins
lipids
carbs
3 classes of proteins
integral
transmembrane
peripheral
3 classes of lipids
phospholipid
spinolipid
cholesterol
Simple Diffusion
lipids
small polar molecules
non-polar gases
Primary Active Transport
large polar molecules
ions
drugs
AA
Secondary Active Transport
large polar molecules
ions
drugs
AA
Endo/Exo/Phago
large macromolecules
waste
lipids
B cells
insulin
Exchange
urinary
circulatory
respiratory
Transporting
urinary
digestive
CIliated
reproductive
respiratory
Protective
integumentary
Secretory
integumentary
circulatory
digestive
Posterior Pituitary
direct connection
Normal Thyroid Func.
Increase in TRH–>increase in TSH–>increase in T3 and T4
Cortisol
steroid hormone
permissive w/ insulin
catabolic
Hypercortisol
primary- tumor
secondary- tumor (cushing’s)
latrogenic (via taking steroids)
Hypocortisolism
Addison’s disease
hyponatremia and hyperkalemia (aldosterone, catechlomines, and cortisol)
ACTH and B-endorphin
Blocks pain and flight/fight
T3 and T4
need iodine
promotes metabolism
Goiter
enlarged thyroid gland (hyper and hypo)
Graves disease
Have TSI that mimics TSH
Exophthalmos
Deposits of mucopolysaccarides
Hypothyroidism
lack of iodine in diet
myxedema (puffy apperance)
decrease protein synthesis
Hypertrophy
Increase in organ site by an increase in cell size
Growth Hormone
anabolic
GH and IGF- stimulate protein synthesis and increases bone growth (antagonostic)
Acromegaly
increase in GH
bones grow more quickly (gigantism)