Evaluation- Effectiveness-Agonist And Antagonist Substitution

Question 1

Effectiveness of Mathadone (strength)

Answer 1

P- found to be effective treatment for opioid addiction
E-Nice- 31 studies (27 randomised controlled trails) methadone= higher retention rate compared to placebo= lower levels of illicit opioid use
Van den brink and haasen- methadone was effective as long as dosage was adequet
E- suggests methadone helps stay engaged= reduced likely-hood of them doing drugs.

Question 2

comparing methadone with buprenorphine

Answer 2

P-Methadone is better at keeping patients compared to bup
E-whelan ans Remski- methadone is more effective in keeping patientsin treatment because effects are stronger, making it more applealing to addicts
Marteau et al found burp eve though its milder its safer (Celing effects) reduces risk of overdose
E-even though bupenorphine is safer

Question 3

effectiveness of naltrexone

Answer 3

P-helps reduce relapse rates for heroine addiction
E-NICE- reviewed 17 studies= conflicting results
many show no big difference between naltrexone and other treatments