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Pharm 4 > Estrogen and Progestin Inhibitors > Flashcards

Estrogen and Progestin Inhibitors Flashcards

1
Q

MOA Clomiphene

A

partial agonist
block estrogen via negative feedback
fertility drug

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2
Q

AE Clomiphene

A

multiple births, hot flashes, ovary enlargment

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3
Q

Actions of SERM

A

Bone - agonist - suppress resorption
Endometrium - partial agonist - promote proliferation
Pituitary - inhibition - hot flashes
Breast - inhibition - inhibit proliferation

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4
Q

SERMs

A

Tamoxifen

Raloxifene

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5
Q

MOA Tamoxifen

A

Used for ER positive breast cancer
Agonist - bone
Partial agonist - endometrium
Antagonist - breast/HPG

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6
Q

AE Tomxifen

A 
Hot flashes (HPG)
Endometrial cancer (endometrium)
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7
Q

MOA Raloxifene

A

Used in cancer and postmenopausal bone loss
Agonist - bone
Antagonist - breast/uterus/HPG

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8
Q

AE Raloxifene

A 
hot flashes (HPG
no endometrium partial agonist = no cancer
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9
Q

MOA Danazole

A

Inhibit gonadal function
Used for endometriosis and breast fibrocystic disease
Mild adrenergic effects

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10
Q

MOA Anastrozole/Letrozole

A

Aromatase inhibitors

Used in breast cancer

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11
Q

AE Anastrozole/Letrozole

A 
hot flashes (low estrogen)
lethargy
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12
Q

Anti-Progesterone drugs

A

Mifepristone

Ulipristal

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13
Q

MOA Mifepristone

A

Abortifacient
<7 weeks gestation: 1st mifepristone, 2nd misoprostol 48h later
Mifepristone - block progeterone receptor
Misoprostol - induce contractions

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14
Q

MOA Ulipristal

A

Emergency contraceptive

up to 5 day contraceptive post intercourse

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15
Q

Other uses for anti-progesterones

A

contraceptive, anti-cancer, induce delivery after fetal death

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Pharm 4 (13 decks)

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