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Pharm 4 > Anti-Fungal > Flashcards

Anti-Fungal Flashcards

1
Q

MOA Amphotericin B

A

Polyene

binds ergosterol forming pore in fungal membrane

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2
Q

RES Amphotericin B

A

decreased membrane ergosterol or reduced affinity

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3
Q

PKX Amphotericin B

A

insoluble (IV administration)

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4
Q

AE Amphotericin B

A

Very toxic

fever, chills, spasms, HTN, nephrotoxicity**

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5
Q

Liposomal Amphotericin B

A

less toxicity due to less interaction with mammalian cell membrane cholesterol

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6
Q

Azoles

A

“AZOLE”
Imidazole - 2 N - KETO, MICO, CLOT + AZOLE
Triazole - 3 N

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7
Q

MOA Azole

A

inhibit ergosterol synthesis

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8
Q

RES Azole

A

efflux pumps
mutation in target enzymes
low ergosterol in membrane

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9
Q

AE Azoles

A

minor interaction with p450

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10
Q

Azole with highest therapeutic index

A

Fluconazole

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11
Q

Interactions with Itraconazole

A

Low pH for absorption
Absorption blocked by antacids, PPI, H2 blockers
Interacts with hepatic enzymes

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12
Q

AE Voriconazole

A

visual disturbances, hallucinations, rash

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13
Q

Broadest spectrum Azole

A

Posaconazole

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14
Q

Topical Azole

A

Efinaconazole

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15
Q

MOA Flucytosine

A

transported into fungal cell

Incorporated into DNA/RNA to inhibit synthesis

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16
Q

RES Flucytosine

A

altered metabolism

17
Q

AE Flutocytosine

A

bone marrow toxicity - anemia, leukopenia, thrombocytopenia

18
Q

MOA Echinocandins

A

“FUNGIN”
inhibit fungal cell wall synthesis
Inhibit B-glucan
High selective toxicity - $$

19
Q

MOA Allylamines

A

Inhibit ergosterol synthesis
Terbinafine (topical/oral)
Naftifine (topical)

20
Q

MOA Nystatin

A

similar MOA of Amphotericin B

Binds to cell wall and creates pores

21
Q

Drug of choice for Aspergillosis

A

Voriconazole

22
Q

Drug of choice for mild/moderate Blastomycosis

A

Itraconazole

23
Q

Drug of choice for severe Blastomycosis

A

Amphotericin followed by Itraconazole

24
Q

Drug of choice for vaginal Candidiasis

A

Azole (topical) or
Nystatin or
Fluconazole (oral)

25
Q

Drug of choice for oropharyngeal Candidiasis

A

Clotrimazole or Miconazole
Nystatin (oral)
Fluconazole

26
Q

Drug of choice for esophageal Candidiasis

A

Fluconazole

27
Q

Drug of choice for invasive Candidiasis

A

Fluconazole or

Echinocandin

28
Q

Drug of choice for Coccidioidomycosis

A

Fluconazole or

Itraconazole

29
Q

Drug of choice for Cryptococcosis

A

Amphotericin B + flucytosine followed by fluconazole

30
Q

Drug of choice for HIV pts with Cryptococcosis

A

Fluconazole

31
Q

Drug of choice for Histoplasmosis

A

Amphotericin + Itraconazole

32
Q

Drug of choice for HIV pts with Histoplasmosis

A

Itraconazole

33
Q

Drug of choice for Mucormycosis

A

Amphotericin B

34
Q

Drug of choice for cutaneous Sporotrichosis

A

Itraconazole

35
Q

Drug of choice for extracutaneous Sporotrichoisis

A

Amphotericin followed by Itraconazole

36
Q

Drug of choice for Dermatomycosis

A

Topical azole or

Topical terbinafine

37
Q

Drug of choice for onychomycosis

A

Oral terbinafine or
Oral itraconazole or
Topical efinaconazole

Pharm 4 (13 decks)

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