Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm 4 > Anti-Diabetic > Flashcards

Anti-Diabetic Flashcards

You may prefer our related Brainscape-certified flashcards:
WSET ® Level 4 D2 Business of Wine flashcards
1
Q

Rapid acting insulin

A

amino acid alteration preventing insulin complex formation
Onset - 10-30 min
Duration 3-5h
Insulin Lispro, Insulin Aspart, Insulin Glulisine, Inhaled Insulin
Mimic meal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Short acting Insulin

A

Identical to human insulin - forms complex
Onset - 30-60min
Duration - 4-12h

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Intermediate acting insulin

A

protamine insulin complex
Onset - 1-2h
Duration - 4-12h
NPH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Long Acting insulin

A 
amino acid substitutions = precipitate form at neutral pH
Onset 1-4h
Duration 12-20h
Peak - none
Glargine, Detemir - mimic basal
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

AE Insulin Therapy

A

Hypoglycemia - treat with glucagon
Hypersensitivity
Resistance
Lipohypertrophy, lipoatrophy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

MOA Metformin

A

Biguanide
Decrease hepatic glucose output, increase peripheral glucose utilization
Activate hepatic enzyme AMP-activated protein kinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

AE Metformin

A

N/V/D, B12 deficiency

No hypoglycemia, not dependent on B-cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

MOA Sulfonylureas

A

Glimepride, Glipizide, Glyburide (2nd gen)

inhibit ATP sensitive K channel of B-cell stimulating insulin release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

MOA Meglitinides

A

Repaglinide, Nateglinide

Inhibit ATP sensitive K channel of B-cell stimulating insulin release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

AE Sulfonylureas/Meglitinides

A

WG, GI, hypoglycemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Acarbose, Miglitol

A

Oral Glucosidase inhibitors - take with meal
inhibition of brush border glucosidase enzyme and absorption of glucose
Contraindicated in pts with GI disease; hypoglycemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Pioglitazone, Rosiglitazone

A

Thiazolidinediones (oral)
Decrease peripheral resistance by activating peroxisome proliferator-activated receptor-y
Affects glucose metabolism and insulin signaling

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

AE Thiazolidinediones

A

Risks outweigh benefits

GI, hypoglycemia, MI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

MOA Pramlintide

A

Injected Amylinomimetic
Inhibit glucagon release, inhibit gastric emptying
Useful for Type I/II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

AE Pramlintide

A

Nausea, vomiting, anorexia, Hypoglycemia, drug absorption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Incretins

A

Exenatide, Liraglutide
potentiate insulin secretion, inhibit glucagon release/gastrin emptying
AE - Nausea, vomiting, diarrhea, hypoglycemia*, pancreatitis, drug absorption
Injected; good for Type II

17
Q

Dipeptidyl Peptidase Inhibitors (DPP)

A

Sitagliptin*, Saxagliptin, Linagliptin
Inhibit incretin degradation
AE - nasopharyngitis, URT infection, headache, pancreatitis
Oral - good for Type II

18
Q

SGLT2 Inhibitors

A

Canagliflozin*, Dapagliflozin, Empagliflozin
Inhibit renal glucose reabsorption
AE - URT infection, hypotension, hypoglycemia, breast/bladder cancer, contraindicated for renal impairment

Pharm 4 (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions