Erythema Multiforme

Question 1

Erythema Multiforme

Answer 1

Erythematous rash caused by a hypersensitivity reaction

Question 2

Causes of erythema multiforme

Answer 2

Viral infections - herpes simplex virus

Medications

Mycoplasma pneumonia

Question 3

Presentation of erythema multiforme

Answer 3

Widespread, itchy, erythematous rash.

Characteristic “target lesions”

Symptoms come on abruptly over a few days.

May be associated with mild fever, stomatitis, muscle and joint aches, headaches and general flu-like symptoms

Question 4

Target lesions

Answer 4

Red rings within larger red rings, with the darkest red at the centre, similar to a bulls-eye target

Question 5

Complication for erythema multiforme

Answer 5

Can cause a sore mouth (stomatitis).

Question 6

Management of erythema multiforme

Answer 6

Supportive management

Question 7

How is a diagnosis of erythema multiforme made

Answer 7

Clinically

If no clear underlying cause:
- CXR - mycoplasma pneumonia

Question 8

How long does erythema multiforme take to resolve

Answer 8

1 - 4 weeks

Question 9

Treatment for severe erythema multiforme

Answer 9

Admission to hospital

IV fluids, analgesia and steroids (systemic or topical).

Antibiotics or antivirals if infection is present