ER: Metabolic/Endocrine

Question 1

Electrolyte abnormalities in Addison’s

Answer 1

Hyperkalemia
Hyponatremia
Hypercalcemia
Hypochloremia

Question 2

Addison’s disease

Answer 2

Hypoadrenocorticism

Deficiency in production of aldosterone, cortisol, or both in the adrenal glands

Question 3

Most common cause of primary Addison’s

Answer 3

Immune-mediated destruction of the adrenal glands

Question 4

Iatrogenic primary Addison’s

Answer 4

Adrenal cortex is destroyed by mitotane

Question 5

Secondary Addison’s

Answer 5

Decreased production of ACTH by the pituitary gland

Causes glucocorticoid (cortisol) deficiency only

Question 6

Iatrogenic secondary Addison’s

Answer 6

Caused by a sudden withdrawal of exogenous high-dose or long-term glucocorticoid therapy

Question 7

Function of mineralocorticoids (aldosterone)

Answer 7

Promotes sodium and chloride reabsorption in the kidneys