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VLL > Epigenetica, hallmarks > Flashcards

Epigenetica, hallmarks Flashcards

1
Q

APOE-gen

A

Codeert voor vettransporter
Epsilon 2: langlevendheid
Epsilon 3: dementie, atherosclerose

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2
Q

Primaire hallmarks

A

Oorzaken van schade

Genoominstabiliteit, telomeerverkorting, epigenetische veranderingen, verlies proteostase

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3
Q

Versnelde veroudering (progeria) bij..

A

problemen transcriptie nucleotide excisie herstel

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4
Q

Antagonistische hallmarks

A

Respons op schade en stress
Gedisreguleerde nutrient sensing (GH-cyclus stoppen), mitochondriale disfunctie (zuurstofradicalen), cellulaire senescentie (p53),

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5
Q

Integratieve hallmarks

A

Drivers verouderingsproces

Stamceluitputting, verminderde intercellulaire communicatie

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6
Q

TOR pathway

A

Onderdeel nutrient sensing (antagonistische hallmark)
Geactiveerd door insuline, groeifactoren en voedingsstoffen
Zorgt voor eiwitsynthese en celgroei
Inhibeert autovagie (opruimen dode cellen)

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VLL (21 decks)

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