Environmental carcinogenesis Flashcards by Daniel Plitnik

Q

NHEJ

A

Non-homologous end joining

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Q

HRR

A

homologous recombination repair

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Q

BER

A

Base excision repair

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Q

NER

A

Nucleotide excision repair

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Q

MMR

A

mismatch repair

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Q

HNPCC

A

Human Non-polyposis Colon Cancer

causes colon cancer

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Q

HNPCC type of damage

A

mismatch repair

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Q

Ataxia telangiectasia

A

lymphomas and leukemias

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Q

Bloom syndrome

A

leukemias, lymphomas, carcinomas

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Q

Cockayne’s syndrome

A

no known cancer

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Q

Trichothiodystrophy

A

no known cancer

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Q

Werner syndrome

A

thyroid cancer, melanoma, sarcoma, osteosarcoma

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Q

Xeroderma pigmentosum

A

skin cancer
sensitive to UV radiation
7 nucleotide excsion repair genes

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Q

gorlin syndrome

A

BCC, meduloblastoma
sensitive to IR
PTCH gene

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Q

pyrimidine dimer formed by

A

254 nm UV

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Q

pyrimidine dimer destroyed by

A

> 320 nm UV

Q

% cancer that are melanoma

A

5%

Q

PAH

A

polycyclic aromatic hydrocarbons

Q

Discovered PAH

A

Percival Pott

Q

PAH in chimney sweeps

A

scrotal cancer