Animal studies Flashcards
1
Q
Goal of dose response studies
A
- ID shape of curve
2. mathematical model for curve
2
Q
positive slope
A
agent produces the health effect
3
Q
zero slope
A
agent does not produce effect
4
Q
negative slope
A
agent protects against health effect
5
Q
steeper slope
A
more potent agent
6
Q
unit risk
A
change in response per unit increase in dose
7
Q
Unit risk is a measure of _____
A
potency
8
Q
threshold
A
some minimum dose level needs to occur before a response occurs
9
Q
Carcinogen threshold
A
NO
10
Q
Toxin threshold
A
YES
11
Q
stochastic
A
cancer
12
Q
non stochastic
A
cataracts, erythema, etc
13
Q
cyclamates
A
animal studies suggested harmful, but was not
14
Q
thalidomide
A
animal studies suggested safe, but was not
15
Q
point of departure
A
beginning of low dose extrapolation
