Dose Flashcards
1
Q
Exposure is _____ to establish potential hazard
A
sufficient
2
Q
Potency requires?
A
Dose response data
3
Q
“The dose makes the poison”
A
paracelsus
4
Q
routes of exposure
A
ingenstion
skin contact
inhalation
skin absorption
5
Q
Dose =
A
C x IR x AF x EF / BW concentration intake rate bioavailability factor exposure factor body weight
6
Q
volumetric conversion factor
A
1 liter/1000 cm^3
7
Q
conversion factor for soil concentration
A
10^-6 kg/mg
8
Q
NHANES
A
National Health and Nutrition Examination Survey
9
Q
potential dose
A
amount of chemical contained in substance swallowed, inhaled or applied to skin
10
Q
potential dose compared to absorbed dose
A
absorbed will always be less.
11
Q
components of an exposure to dose conversion
A
- concentration at the point of contact
- calculate exposure
- determine intake rate
- estimate potential dose
- calculate time-weighted dose
12
Q
gas under STP
A
mg/m^3 = ppm x MW/24.5
13
Q
inhalation default rate
A
20 m^3 air per day
14
Q
drinking default rate
A
2 L water / day
15
Q
Average daily dose (ADD)
A
average dose per day over period of interest
