Enterococchi Flashcards

1
Q

GRAM ENTEROCOCCHI

A

GRAM+

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2
Q

Classificazione ENTEROCOCCHI

A

γ emolitici
Catalasi negativi
Aerobi/anaerobi
Commensali tratto vaglinale - GI

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3
Q

E.Faecium - E.Faecalis

A

Virulenza non elevata
Infenzioni nosocomiali
Infezioni vie urinarie

Fattori di rischio:
- cateteri
- terapia antibiotica ampio spettro

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4
Q

Resistenza antibiotica Enterococchi

A

Intrinseca (cefalosporine)

Acquisita ( aminoglicosidi -vancomicina)

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5
Q

Resistenza aminoglicosidi e vancomicina

A

Enterococchi

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6
Q

Fattori virulenza enterococchi

A
  1. Capacità di aderire a tessuti (pili-biofilm-gelatinasi)
  2. Acquisizione / trasferimento fattori di resistenza
  3. Resistenza antibiotica
    - intrinseca
    - acquista
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7
Q

Manifestazioni cliniche ENTEROCOCCHI

A

Infezioni noscomiali gravi
- infezioni urinarie (cistiti)
- endocardite grave
- meningiti
- infezioni respiratorie neonati

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8
Q

Diagnosi enterococchi

A

Test PYR —> PYR positivo + Catalasi negativo + coppie / corte catene

Test biochimici - sequenziamehto

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9
Q

Terapia enterococchi

A

Combinazione sinergica aminoglicosidi + inibitori parete cellulare

E.Faecium resistenze
- penicillina - ampicillina
- possibile VRE
- resistenza ad aminoglicosidi

Antibiotici alternativi

Linezolid + daptomicina + tigeciclina +

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10
Q

E.Faecium resistenze

A

Penicillina ampicillina

Vancomicina (VRE)

Aminoglicosidi (più del 25%)

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11
Q

Antibiotici alternativi per enterococchi

A

Linezolid

Tigeciclina

Daptomicina

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12
Q

R: aminoglicosidi / S: ampicillina (enterococchi)

A

Ampicillina + daptomicina + linezolid/imipenem

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13
Q

R: ampicillina + S: aminoglicosidi

A

Aminoglicosidi + vancomicina (se attiva) + daptomicina / Linezolid

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14
Q

R: ampicillina + R: aminoglicosidi

A

Daptomicina + linezolid / vancomicina + agente attivo

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