Enterobacteriaceae II Flashcards
T/F Shigella is lactose and indole positive
FALSE
Shigella is lactose NEGATIVE, even though many enterobacteriaceae do ferment lactose
Shigella has no H antigen, and is therefore _____
Non-motile
What are the four important species of Shigella?
- S. dysenteriae (A)
- Most dangerous - shiga toxin and neurotoxin
- S. flexneri (B)
- S. boydii (C)
- S. sonnei (D)
What is the route of transmission for Shigella?
Fecal oral
F’s: Fecal oral, fingers, flies, feces, food, fomites, fornication (MSM)
Shigella adheres to _____ in gut lymphoid tissue
M cells
Shigella moves laterally between cells by _____
Polymerizing actin (kinda like listeria)
Due to its _____ existence, cell mediated immunity to Shigella is important
Intracellular (taken up by macrophages)
When taken up by macrophages, Shigella causes the production of pro-inflammatory cytokines, causing the formation of _____ that cause its bloody diarrhea
Ulcers
Some Shigella species secrete Shiga toxin. Because of this, infected kids may develop _____, a serious sequelae of infection
Hemolytic Uremic Syndrome
What is the treatment for Shigellosis?
- Rehydration (pedialyte)
- Cipro
- Ceftriaxone
The most severe form of Shigellosis is known as _____. What is the cause of its symptoms? What species causes it? What is the characteristic lesion seen?
- Bacillary Dysentery
- Symptoms caused by systemic effects of Shiga toxin and neurotoxin
- Caused by S. dysenteriae (Serogroup A)
- Characteristic “flask shaped” ulcers seen
Salmonella, like Shigella, is both _____ and _____ negative
Indole and Lactose negative
(For comparison, E. Coli is POSITIVE for both indole and lactose, useful bit for diagnosis)
T/F Salmonella is motile
TRUE
T/F Salmonella produced hydrogen sulfide
TRUE
Gastroenteritis is caused by Salmonella enterica subspecies other than _____.
Typhi (Typhimurium is the most important gastroenteritis causing form for us)
How is Salmonella transmitted to humans?
- Consumption of contaminated food products
- Raw chicken and eggs
- Reptile contact
- Baby turtles
T/F Salmonella is similar to Shigella in that is acid resistant
FALSE
Salmonella is sensitive to stomach, in contrast to Shigella
The symptoms of Salmonella infection include nausea, vomiting, cramps, diarrhea, and sometimes fever appearing _____ after ingestion
8-12 hours