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Bacteriology > Chlamydia > Flashcards

Chlamydia Flashcards

1
Q

T/F: Chlamydiaceae is an obligate intracellular pathogen

A

TRUE

They reproduce within the host cell

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2
Q

How do Chlamydiaceae appear on gram stain?

A

Gram negative, but no detectable peptidoglycan layer

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3
Q

What are the treatment options for Chlamydia?

A
  • Azithromycin
  • Tetracycline
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4
Q

What morphologic form of Chlamydia is infectious, survives extracellularly, has minimal metabolic activity, and is rigid?

A

Elementary body

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5
Q

What morphologic form of Chlamydia replicates intracellularly, is not infections, is metabolically active, undergoes binary fission and is osmotically fragile?

A

Reticulate body

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6
Q

Describe the tropism of C. trachomatis serovars A-C

A

Conjunctival epithelial cells

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7
Q

How are C. trachomatis serovars A-C transmitted?

A

Contact with ocular drainage (primarily child-child spread)

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8
Q

C. trachomatis serovars A-C cause what disease?

A
  • Trachoma
    • Chronic keratoconjunctivitis
    • Leading cause of preventable blindness in developing countries
    • Active disease wanes in 6-10 years, with blindness resulting 25-30 years later
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9
Q

Describe the tropism of C. trachomatis serovars D-K

A

Columnar epithelial cells

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10
Q

How are C. trachomatis serovars D-K transmitted?

A

Sexual contact/secretions

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11
Q

T/F C. trachomatis serovars D-K increase host susceptibility to and transmission of HIV

A

TRUE

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12
Q

T/F: Most women with C. trachomatis D-K infections show symptoms

A

FALSE

80% are asymptomatic (30-40% males)

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13
Q

C. trachomatis D-K infections are similar to N. gonorrheae infections except they are…

A
  • Less abrupt in onset
  • Less inflammatory
  • Milder symptoms
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14
Q

In men, C. trachomatis D-K typically manifests as a _____

A

Urethritis

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15
Q

C. trachomatis D-K typically infects the _____ in women

A

Endocervix (cervicitis)

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16
Q

In women, C. trachomatis can ascend into the upper GU, causing _____

A

Pelvic Inflammatory Disease

17
Q

T/F: C. trachomatis is the most common cause of neonatal conjunctivitis in the US

A

True

18
Q

Neonatal C. trachomatis pneumonia has a distinctive _____ cough

A

Staccato

19
Q

Describe the tropism of C. trachomatis serovars L1-L3

A

Mostly macrophages in lymphatic and subepithelial tissue

20
Q

How are serovars L1-L3 of C. trachomatis transmitted?

A

Sexual contact/secretions

21
Q

Lymphogranuloma Venereum is caused by what C. trachomatis serovars? Who does it mostly effect? Sx?

A
  • C. trachomatis L1-L3
  • Mostly seen in MSM
  • Inguinal adenopathy, fever, chills, arthralgia
    • Nodes can become suppurative (buboes) as organism multiplies
22
Q

What is the cause of Ano-Genital-Rectal syndrome?

A

Rectal mucosa directly inoculated with C. trachomatis L1-L3 or lymphatic spread → Lymphatic blockage → Enlargement of genitalia and rectal stricture

23
Q

What stain is used for diagnosis of C.trachomatis?

A

Giemsa

24
Q

What is the most common form of labaratory diagnosis of Chlamydia today?

A

NAAT From swab

25
Q

Describe the tropism of C. psittaci

A

Epithelial cells and mononuclear phagocytes

26
Q

T/F: Transmission of C. psittaci is human-human

A

FALSE

It is a zoonosis. Transmitted via inhalation of dried bird excrement, urine or respiratory secretions

27
Q

Human disease caused by C. psittaci most commonly presents as _____

A
  • Atypical pneumonia
    • Dry cough
    • Insidious onset w/malaise and myalgia
    • OR abrupt onset w/high fever, rigors, headache
    • Severe cases can be complicated by CNS involvement
      • Meningitis, meningoencephalitis
28
Q

How is laboratory diagnosis of C. psittaci accomplished?

A

Complement fixation tests on acute convalescent sera

No idea what that means

29
Q

What are the abx of choice for C. psittaci infxn?

A
  • Doxycycline
  • Azithromycin
  • Clarithromycin
30
Q

Describe the tropism of C. pneumoniae

A

Epithelial cells & macrophages

31
Q

C. pneumoniae causes _____ and _____ in humans

A

Atypical pneumonia and a range of respiratory diseases (pharyngitis, bronchitis, O.M.?)

32
Q

What are the abx of choice for C. pneumoniae infection?

A
  • Doxycycline
  • Azithromycin
  • Clarithromycin

Bacteriology (19 decks)

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