Endocytosis and Protein Degredation

Question 1

What does Hsp70 do?

Answer 1

Binds to protein as it is being made and helps fold protein.

Question 2

What does hsp60 do?

Answer 2

It binds protein after synthesis and then uses ATP to relax the protein and allow it to refold.

Question 3

How does the cell know if a protein is properly folded?

Answer 3

UGGT (UDP-glucose:glycoprotei glucosyl transferase) recognizes it and its something we don’t understand completely.

Question 4

What marks a protein for degradation?

Answer 4

Ubiquitin.

Ubiquitin also does other things.

Question 5

How many ubiquitins are needed to degrade a protein?

Answer 5

4 or more

Question 6

Which subunit of the proteasome cleaves hydrophobic AA?

Answer 6

B5 Chymotrypsin-like (Hydro has 5 letters in it)

Question 7

Which subunit of the proteasome cleaves basic AA?

Answer 7

B2- trypsin like- “B”asic

2nd letter in the alphabet

Question 8

Which subunit of the proteasome cleaves acidic AA?

Answer 8

B1 Caspase like- “A”cidic.

A is the first letter in alphabet

Question 9

Patients with which disease are immune to ebola?

Answer 9

Niemann-Pick