Autophagy

Question 1

What is macroautophagy?

Answer 1

formation of 2 membrane vehicle with cargo in them, The macroautophagasome then binds with the lysosome to degrade the cargo (organelles, proteins etc.).

Responsible for bulk degredation of cellular material.

Question 2

True or false: vesicles formed by endocytosis may join with autophagosomes.

Answer 2

True

Question 3

What happens when mice are born and after periods of starvation?

Answer 3

Autophagy increases. If mice lack the genes for autophagy, then they die shortly after birth.

Autophagy is important during nutrient deprivation (fasting)

Question 4

What is the main gene responsible for autophagy?

Answer 4

Atg- This class of genes are enzymes.

Question 5

Autophagy is sometimes described as the bulk destruction of cellular stuff. Is this process specific of general?

Answer 5

It can target specific cargo with cargo receptor. One example is iron.

Question 6

True or false: cells want autophagy during apoptosis

Answer 6

False.

They don’t want to work at the same time because many proteins that control apoptosis can also control autophagy if cleaved correctly.

Question 7

True or false: Autophagy is a protective measure of the cell

Answer 7

Partially true, but FALSE: It can aso kill cells

Question 8

Name a few diseases that may be treatable by upregulating autophagy.

Answer 8

Neurological diseases such as alzheimers, huntingtons, etc.

Question 9

What are the two main types of autophagy?

Answer 9

Macroautophagy (double layered vesicle fuses with lysosome.)

Chaperone Mediated(recognition of proteins with a recognition sequence. Direct delivery to lysosome.