ECM and Cell Adhesions

Question 1

What are the 4 classes of ECM Molecules?

Answer 1

1. GAGs- Proteoglycans
2. Fibrous Proteins- Elastin and collagen
3. Multidomain adapter proteins (fibronectin and laminin)
4. Fluid

Question 2

What makes up the basal lamina?

Answer 2

Collagen 4 and laminin

make a net with 2 fingers on each hand

Question 3

What are some examples of GAGS?

Answer 3

Hyaluronic acid, Chondroitin, and lots of –Sulfates.

Question 4

What are some functions of PGs (proteoglycans)?

Answer 4

Filter in kidney, reservoirs of growth factors, membrane bound molecules.

Question 5

What do fibronectins bind to?

Answer 5

Integrins.

Question 6

What do Martix Metalloproteases do?

Answer 6

They are responsible for ECM turnover. They cut through the ECM like a machete.

Question 7

What are the 3 types of Cell Adhesion molecules? What does each cell do?

Answer 7

1. Cadherins- bind to other cadherin on neighboring cells.
2. Ig Superfamily CAMs-don’t form dimers and don’t need calcium
3. Integrins- Anchor cell to ECM

Question 8

Loss of catenin function_________

Answer 8

Promotes carcinogenesis.