ENDOCRINOLOGY - EXTRA QUESTIONS Flashcards
What endocrinopathy might present as dyspnoea and dysphagia?
Hyperthyroidism due to thyroid carcinoma IN DOGS(>50%)
Normally presentation: Weight loss despite normal appetite, PU/PD (due to increased CO/ Renal blood flow), restlessness
How does the cause of hyperthyroidism differ in DOGS and CATS?
Dogs: Thyroid carcinoma
Cat: Adenomatous hyperplasia
Why are cervical radiographs recommended in cases of canine hyperthyroidism?
Thyroid carcinoma is frequently metastatic. Lungs most commonly affected, local lymph nodes
Relevance of adjuvant therapy when treating hyperthyroidism>
Adjuvant therapy: Following incomplete thyrodectomy may be useful in further shrinking remaining tissue.
C.F. Neoadjuvant therapy which is GIVEN BEFORE
Normal signalment of feline hyperthyroidism
12-13 years in cats (c.f. with dogs 9-10 yrs)
no breed susceptibility
What serum biochemistry abnormalities are common in cats with hyperthyroidism?
Milk to marked increase in ALT and ALP
c.f. to canine hyperthyroidism which raised liver enzymes are not related
Why might cervical radiographs be recommended in cases of feline hyperthyroidism?
Check for cardiac hypertrophy ( left ventricular hypertrophy) c.f. canine where taken to assess for mets. NOT in FELINE as adenomatous hypertrophy
How does diagnosis of hyperthyroidism vary in cats and dogs?
Dogs: Elevated T4, Carcinoma
Cats: T4 is less useful in cats.T4 suppression test (
The effects of circulating GH can be divided into two main categories: rapid __ and slow ___
Rapid catabolic actions: Due to insulin antagonism i.e. enhanced lipolysis, gluconeogenesis due to insulin antagonism
Slow (long lasting) hypertrophic actions mediated via IGF-1
What is acromegaly
Acromegaly is a syndrome of bone and soft tissue overgrowth and insulin resistance due to excessive GH secretion
Bovine Surgery incisions is normally made on the ___ hand side
LEFT HAND SIDE. (Right = intestinal loops)
Most common cause of acromegaly in dogs?
Exogenous progestins (oestrous prevention), endogenous progesterone (luteal phase) OR primary hypothyroidism
When is acromegaly most common in female dogs?
3-5 weeks after oestrous. Mainly middle aged elderly female dogs during LUTEAL PHASE OF CYCLE
What can be a second complication of acromegaly be?
Diabetes mellitus due to insulin resistance therefore acromegalic dogs can present with polyuria
Diagnosis via plasma IGF-1 assay (can use human assay)
