Endocrinology AI 2 Flashcards
How long does it typically take for animals with partial CDI or psychogenic polydipsia to become dehydrated during the modified water deprivation test?
1-3 days.
What is the urine SG range for animals with partial CDI after dehydration in the modified water deprivation test?
1.008-1.020.
What is the response to desmopressin therapy for animals with CDI (complete and partial)?
Positive.
What is the urine SG range for animals with primary NDI during the modified water deprivation test?
<1.008 (no change).
What is the urine SG range for animals with psychogenic polydipsia during the modified water deprivation test?
> 1.030.
What should be monitored during the assessment of a clinical response to trial desmopressin therapy?
Water intake.
How long is synthetic desmopressin (DDAVP) administered via the conjunctival sac during the trial therapy?
Several days.
What is the most common presenting sign in animals with sex predisposition?
PU/PD (polyuria/polydipsia)
What are the clinical signs of CDI in animals?
Increased water intake, increased urine volume, weight loss, and excessive drinking
What can excessive water consumption in animals with CDI lead to?
Vomiting and nocturia
What are the clinical signs of CDI in animals with partial CDI?
Less marked clinical signs compared to full CDI
What additional neurological signs can develop in dogs with pituitary or hypothalamic neoplasia?
Neurological signs due to invasion or compression of adjacent tissue
What can cause neurological signs in dogs and cats?
Head trauma or multifocal/widespread inflammatory, infectious, and developmental structural CNS defects
What are the possible endocrine abnormalities associated with lesions affecting the pituitary gland?
Congenital or acquired lesions can cause CDI, pituitary dwarfism, secondary hypothyroidism, secondary hypoadrenocorticism, and decreased GH production
What can indicate the presence of hyperadrenocorticism in dogs with CDI?
Dermatological and metabolic changes associated with hyperadrenocorticism
What syndrome can occur if animals with CDI experience severe water restriction?
Hypertonic dehydration
What are the clinical signs of hypertonic dehydration in animals with CDI?
Anorexia, weakness, disorientation, ataxia, and seizures
Is there a single confirmatory test for CDI in dogs or cats?
No, diagnosis requires thorough exclusion of other causes of PU/PD
What are the remaining differential diagnoses if PU/PD cannot be attributed to any other cause?
CDI, primary nephrogenic diabetes insipidus, and primary polydipsia
When can a modified water deprivation test or desmopressin trial be performed to distinguish between CDI and other conditions?
Only after thorough exclusion of other causes of PU/PD
What abnormalities may be observed in routine clinicopathological findings of dogs or cats with CDI?
No significant abnormalities, provided water is not restricted
What can cause reduced serum urea concentrations in dogs or cats with CDI?
Renal medullary solute washout and loss of ADH-dependent urea reabsorption
What abnormalities may be observed if water is restricted in animals with CDI?
Elevated haematocrit, hyperproteinaemia, hypernatraemia, and prerenal azotaemia
What can cause severe hypernatraemia and serum hyperosmolality in CDI?
Hypertonic dehydration