Endocrinology Flashcards
Endocrine
Hormone secreted into blood binds distant target cells
Paracrine
Hormone acts locally by diffusing from its source to target cells in the neighborhood
Autocrine
Hormone acts on same cell that produced it
Steroids
Originate from cholesterol precursor
Hypothalamus
Lies below third ventricle at base of brain
Pituitary gland
Endocrine gland connected to hypothalamus by infundibulum
Anterior pituitary
Releasing hormones
Inhibiting hormones
Posterior pituitary
Oxytocin
Antidiuretic hormone ( ADH)
Nonpeptide hormone
Dopamine most important inhibitor of prolactin
Corticotropin releasing hormone
Acts on corticotrophs in the anterior pituitary to stimulate production of ACTH
GnRH
Acts on gonadotropes in the anterior pituitary to stimulate production of FSH and LH
GHRH
GHIH
GHRH- acts on somatotrophs in the anterior pituitary stimulates production of GH
GHIH- also called somatostatin in the anterior pituitary and inhibits production of GH
TRH
Acts on thyrotrophs of the anterior pituitary to stimulate TSH
PRH
Acts on lactotrophs in the anterior pituitary
Stimulates prolactin
Dopamine
Acts on lactotrophs to INHIBIT production of prolactin by the anterior pituitary
Oxytocin
Uterine contraction and milk let down
Inhibited by progesterone
What does ADH do
Decreases urine output
Increases water resorption
Decreases sweating
Increases blood pressure
V1 receptors
Blood vessels
V2 receptors
Renal collecting duct epithelial cells
V3 receptors
Mediating ACTH secretion from the anterior pituitary
Diabetes Insipidus
Lack of ADH production or response
Characteristics of diabetes inipidus
Dilute urine
Problem in hypothalamus
Rise in urine osmolality following administration of ADH