Endocrine System Flashcards
endocrine glands are a group of organs that synthesize and release ______ into capillaries
hormones
the _____ can be considered an endocrine organ in that the basal hypothalamus secretes hormones.
brain
the nervous and endocrine elements of control are often lumped together under the heading ____ system
neuroendocrine
= hypophysis
pituitary gland
=pituitary gland
continues with the hypothalamus of brain at the median eminence
hypophysis
an endocrine organ with obvious neural and non neural endocrine components
pituitary gland, hypophysis
derived from a portion of the forming brain called the infundibulum of the diencephalon
neural hypophyseal tissue
neural hypophyseal tissue is derived from a portion of the forming brain called the infundibulum of the diencephalon
infundibulum of the diencephalon
non neural hypophyseal tissue is derived from the external epithelial lining of a structure called ____ in birds and mammals
Rathke’s Pocket
is derived from the external epithelial lining of a structure called Rathke’s Pocket in birds and mammals
non neural hypophyseal tissue
diencephalic infundibulum (posterior lobe of the pituitary) forms ___
neurohypophysis
(posterior lobe of the pituitary) forms neurohypophysis
diencephalic infundibulum
pars nervosa =
continues with the hypothalamus of brain at the median eminence
neurohypophysis
neurohypophysis =
pars nervosa
the epithelial lining of Rathke’s pocket forms the _____(anterior lobe of the pituitary)- non neural hypophysis
andenohypophysis
the epithelial lining of ____ _____ forms the adenohypophysis (anterior lobe of the pituitary)- non neural hypophysis
Rathke’s pocket
three parts of the adenohypophysis
- pars distalis
- pars intermedia
- pars tuberalis
anterior lobe of the pituitary, largest component of the adenohypophysis
pars distalis
lies between neurohypophysis and pars distalis
pars intermedia
andenohypophysis tissues that surround the stalk of the pars nervosa
pars tuberalis
5 arteries provide blood to the pituitary gland
2 superior hypophyseal arteries
2 inferior hypophyseal arteries
Trabecular artery
venues that form from capillaries in the median eminence extend through the pars tubercles, enter the pars distal is, and form a second capillary network (a portal system) within its tissue =
hypothalamic hypophyseal portal system
2 major classes of cells are present in the pars distalis
chromophobes and chromophils
in the pars distalis
cytoplasm doesn’t pick up stain
cytoplasm appears white or clear
form supporting network for adenohypophysis tissues
chromophobes
in the pars details
these cells pick up basic or acidic stains - basophils and acidophils
chromophils
basophils in the pars distalis are _____ cells and secrete
gonadotropic cells
secrete hormones that affect reproductive organs
FSH: follicle stimulating hormone
LH: leuteinizing hormone
ICSH: in males, interstitial cell stimulating hormone
glycoprotein that stimulates and supports early growth of follicles in ovary and spermatogenesis in testis
FSH follicle stimulating hormone
glycoprotein that reaches peak during menstrual cycle. 24 hr after peak, ovulation occurs
LH leuteinizing hormone
stimulates interstitial cells of leydig in testes to secrete testosterone
ICSH: in males, interstitial cell stimulating hormone
acidophils in the pars distalis are _____ cells and secrete
mammotropic sells
secrete prolactin
and
somatotropic cells
secrete growth hormone -somatotropin
peptide hormone that triggers secretion of milk by mammary glands
prolactin
lack of this hormone results in hypopituitary dwarfism which can be treated in some cases with hormone injections
growth hormone
somatotropin
overproduction of this hormone can cause gigantism and may eventually result in acromegaly
growth hormone
somatotropin
major effect of ____ is to increase permeability to water of the tubules of the kidney. Causes a higher rate of reabsorption of watery the cells of the tubule epithelial lining and thus concentrates the urine
vasopressin
____ promotes contraction of the smooth muscle of the uterine wall during copulation and parturition. also, promotes contraction of myoepithelial cells that surround ducts of mammary glands
oxytocin
paired organs that usually lie on the superior poles of the kidneys, embedded in adipose tissue
- have dense collagenous CT capsule
adrenal glands
2 major regions of the adrenal glands
adrenal corten and adrenal medulla (center)
the supporting framework of the adrenal cortex and medulla is called the ____, which is mainly composed of reticular fibers
stroma
as an embryo develops, the cortex of the adrenal gland is derived from ______ cells in the region of the kidney
mesodermal cells
the cells of the adrenal medulla are derived from a specialized group of neural ectoderm cells that are called the ___ ____
neural crest
3 layers of adrenal cortex
outer capsule cortex 1. zona glomerulosa 2. zona fasciculata 3. zona reticularis medulla
in the adrenal cortex,
columnar to pyramidal cells arranged in FOLDED CORDS surrounded by capillaries/ sinusoids
- stain darker
- outer layer nearest the capsule
zona glomerulosa
in the adrenal cortex
these cells secrete mineral corticoids, mainly aldosterone which is important in maintaining water balance
- not a large # of lipid droplet in cytoplasm
zona glomerulosa
hormone secreted by the zona glomerulosa of the adrenal cortex that is important in maintaining water balance
aldosterone
in the adrenal cortex
- cells are polyhedral and are arranged in straight cords (columns) with capillaries running B/T
- stain lighter, middle layer and lightest staining
- many lipid droplets present in cytoplasm
zona fasciculata
in the adrenal cortex,
these cells secrete glucocorticoids, mainly cortisol and sex hormones
zona fasciculata
hormone secreted by the zona fasciculata of the adrenal cortex that is important in the regulation of lipid, protein, and carbohydrate metabolism
cortisol
in the adrenal cortex
closest layer to the medulla
cells are polyhedral with spherical nucleus and arranged in irregular cords with capillaries and sinusoids in between
lipofuscin granules in cells
cells secrete androgens, progesterone and estrogen
zona reticularis
in the adrenal cortex
cells secrete androgens, progesterone and estrogen
zona reticularis
secretory granules in the adrenal medulla that stain brown are called
chromaffin cells
epinephrine and norepinephrine are secreted from the
adrenal medulla
located below the larynx, partially encircling the esophagus
- covered by a capsule of loose CT
thyroid
inter follicular connective tissue that separates follicles in the thyroid contain lots of
reticular fibers
the thyroid tissue is separated into lobes that are composed of ____, each containing a lumen filled with a gelatinous substance _____
follicles
colloid
each follicle of the thyroid consists of a ___ ____ ____ surrounding the colloid
simple cuboidal epithelium
cells of the thyroid follicles are responsible for synthesis of thyroid hormones, the most abundant of which is
thyroxin
the main thyroid hormones are (2)
- thyroxine (T4)
2. triiodothyronine (T3)
in addition to follicle cells, _____ _____ are found between the follicles in humans
parafollicular cells
these cell secrete calcitonin that causes a reduction of calcium in the blood, in part by inhibiting the activities of osteoclasts
parafollicular cells
this polypeptide is secreted by parafollicular cells
- causes a reduction of valium in the blood by inhibiting osteoclasts
calcitonin
small organs embedded in the wall of the thyroid
parathyroid glands
complete removal of the thyroid gland was noted to cause death because of spasms of the laryngeal and thoracic muscles that prevented breathing _ called ___
tetany
3 cell types in the parathyroid glands
- adipose cells (increase in # with age)
- chief or principal cells
- oxphil cells
secrete parathyroid hormone
pale staining cytoplasm
chief or principal cells
not present at birth
start appearing in parathyroid tissues around age 7
unknown function
acidophilic cytoplasm
oxyphil cells
major function of parathyroid glands
parathyroid hormone causes increase in calcium in the blood by promoting activity of osteoclasts in the breakdown of calcified matrix
this hormone causes an increase in blood calcium levels
opposite calcitonin
parathyroid hormone
pair of hormones that balance and regulate calcium levels in the body
calcitonin ( of thyroid parafollicular cells ) parathyroid hormone ( of chief cells of parathyroid)