Endocrine regulation of Appetite Flashcards
Area in the CNS regulating Appetite
the Arcuate nucleus in the hypothalamus
Endocrine factors that promote Hunger (orexia)
Ghrelin released from the stomach and ILP5 released from the colon
What nucleus do orexic peptides work on
The NPY neurons that release NPY and AgRP
What region of the brain does NPY and AgRP act on
lateral Hypothalamus to release orexin and MCH to promote hunger
What endocrine factors inhibit hunger (anorexia)
There are factors released from the SI such as GLP-1, CCK, Oxyntomodulin, urguanlin and PYY and and then there are factors released from apipocytes such as leptin and then there are factors released by the pancrease islets such as amylin, insulin and pancreatic polypeptide
What neurons do anorexic peptides work on
POMC neurons release aMSH and CART to suppress appetite
What nucleus do anorexic nueropeptides aMsH and CART work on
The paraventricular nucleus of the hypothalamus and these release oxytocin and CRH
CCK is released from?
I cells in the SI
PYY released from
L cells
ILP-5 released from
Colon
Oxyntomodulin from
L cells
Ghrellin released from
Stomach
GLP-1 released from
L-cells
Uroguanylin is released from
Enterochromafin cells
What are the two most potent peripheral hunger controlling factors
Leptin and Ghrellin
What role do microbiota have in obesity
Certain microbes in the gut may regulate the total energy that absorbed across the gut and hence if more energy is absorbed then obesity
What occurs after fasting and weight loss
Thhe orexic hormones will increase substantially while the anorexic hormones decrease, it takes around 2 years for this set point to reset, hence this is the reason why it is hard for people to loose weight
