Endocrine Pharm: MOA and AE Flashcards
What are the growth hormone drugs?
Somatotropin (hGH)
Somatrem (hGH + 1 methionine)
IGF-1 or somatomedin C (hIGF-1)-mescermin
What are the growth hormone antagonists?
Pegvisomant
What are the somatostatin analogs?
Octreotide
Lanreotide
What are the dopamine receptor agonists to decrease prolactin?
Cabergoline
Bromocriptine
What are other growth inducing drugs?
Thyrotropin (TSH) LH FSH Menotropin recombinant FSH=follitropin alpha Follitropin Beta
What are thyroid drugs?
Levothyrocine=T4
Liothyronine sodium=T3
Liotrix=T4/T4 mixture
What drug is a T4/T3 mixture?
Liotrix
What drug is just T3?
Liothyronine sodium
What drug is just T4?
Levothyroxine
What drugs inhibit thyroid?
PTU: propylthiouracil
Methiomzole
Potassium Iodine
Radioactive iodine
What are the non human insulins?
beef
pork
sheep
What are the modifide crystal size insulins?
NPH insulin NPH/Reg (50/50) NPH/reg (70/30) Lente Semilente Ultralente
What ar the synthetic human insulins and analogs?
Recominant human insulin (humulin) Human insulin made by swithcing aa of pork insulin (Novolin) Insulin: Lispro Aspart Glarnine Detemir Glulisine
What are the classes of drugs for type II diabetes?
StAB Mellitus: Sulfonylureas Alpha-glucosidase inhibitors Bile acid sequestrates Metformin
What are the first generation sulfonyureas?
1st gen: Tolbutamide Chlorpropamide Tolazamide Acetohexamide
What are the second gen sulfonylureas?
Glyburide
Glipizide
Gliclazide
Glimepiride
Repaglinide Nateglinide Metformin Rosiglitazone Pioglitazone Rosiglitazone+metformin
What are the alpha glucosidase inhibitors?
Acarbose
Miglitol
What are the incretins (GLP-1 receptor agonists)?
“tide”
Exenatide
Liraglutide
What are the incretins (dipeptidyl peptidase -4 inhibitors?
“Gliptins”
Sitagliptin
Linagliptin
Saxagliptin
What are the amylin analogs?
Primalintide
What are the bile acid sequestrates?
Colesevalam hydrochloride
What are the drug combinations almost all made with?
Metformin+ Glyburide Rosiglitazone Pioglitazone Glipizide Sitagliptin
What are the cortisols?
-sones
What is the exogenous aldosterone?
Fludrocortisone
What are the antagonists of aldosterone action?
Spironolactone
Aminoglutethimide
Ketokonazole
What are the exogenous PTH?
Teriperidide
Full length hPTH
What are the exogenous calcitonins?
Synthetic human calcitonin hCT
Natural salmon calcitonin
What are the vitamin D agents?
Cholecalciferol=D3 ergosterol ergocalciferol=D2 25-OH cholecalciferol Calcipotriol Dihydrotachysterol=D2 Paricalcitol 22-oxacalcitriol calcitriol
Cinacalcet
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Calcium
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Fluoride
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