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Endocrine > Endocrine: Bone Biochemistry and Histology > Flashcards

Endocrine: Bone Biochemistry and Histology Flashcards

1
Q

Lines between Haversian Systems?

A

Cement Lines

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2
Q

Outside shaft of bone?

A

Cortical Bone

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3
Q

Support of bone?

A

Trabeculate bone

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4
Q

Two types of bone?

A

Cortical and Trabeculate

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5
Q

What part of haversian system contains blood vessel?

A

Central canal

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6
Q

What is the organic component of bone?

A

Type I collagen

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7
Q

What is the inorganic component of bone?

A

Hydroxyapatite

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8
Q

What is the embryological source of pre-osteoblasts?

A

Mesenchyma

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9
Q

What controls osteoblast differentiation?

A

BMP (TGFB superfamily)

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10
Q

What is expressed on osteoblasts?

A

PTH receptor and RANKL

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11
Q

What connects osteocytes?

A

Long cellular processes in canaliculi

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12
Q

What does osteoclast express?

A

RANK-R, acid

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13
Q

What stimulates pre-osteoblasts to express RANK-L?

A

PTH

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14
Q

What promotes osteoblast and osteoclast differentiation?

A

Vit D3

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15
Q

What induces apoptosis of osteoblasts?

A

Cortisol

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16
Q

What does calcitonin do to osteoclasts?

A

Inhibit

17
Q

What increases bone resorption?

A

PTH
GC’s
T4/T3
Vit D (high levels)

18
Q

What decreases bone resorption?

A

Calcitonin

Gonadal steroids

19
Q

What increases bone formation?

A

Growth hormone
Vit métabolites
Gonadal steroids

20
Q

What decreases bone formation?

A

GC’s

21
Q

What happens to bone plate if osteoclasts cannot be stimulated by RANKL?

A

Thick and malformed

22
Q

What type of collagen in cartilage?

A

Type II with aggrecan

23
Q

When does SOST stop being expressed by osteocytes?

A

Fracture

Increased differentiation to osteoblasts

24
Q

What is osteoporosis mostly caused by?

A

Decrease in estrogen, no inhibition of osteoclast activity

Endocrine (15 decks)

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