Endocrine COPY Flashcards
What kind of drug can you give to someone who has gigantism?
Somatostatin
sandostatin
sandovert
these are hypothalamic releasing hormones
gonandotropin releasing hormone
route chemical castration given
Injection only
somatostatin analog
Octreoid (Sandostatin)
gonandotropin releasing hormone
Somavert Contraindications
obesity
respiratory impairment
SE of corticosteriods
edema peptic ulcers delayed wound healing infections osteoporosis
CI for steriod use
these are drugs that end in -ONE
viral and fungal infections because its supressing the immune system
example of a mineralcorticoid
aldosterone
drugs that enhances corticosteriods
(lack of androgen)
estrogen
Birth control pills
(lack of cortisol)
ketoconazole (immune response)
macrolide ABX
(improve GI distress)
diuretics
decrease the effects of corticosteriods
Antacids
cholestyramine
carbazepine (anticonvulsant mood stabilizer)
phenytoin (seizure, their CNS is already altered)
Rifampin
myxedema
is seen in which dx?
facial swelling, peiorbital edema, cheek edema tounge swollen
hypothyroidism
late clinical manifestations of HypOthyroidism
subnormal temp weight gain bradycardia decreased LOC thickened skin cardiac complications
how is Synthroid dosed?
mcg
Synthroid
long half life
takes time to work- 3 months and have dose readjusted
t4 replacement
synthroid
synthroid pt education
take in morning
take with food
no grapefruit
no antacids
no iron supplements
stick with one brand
pregnancy risk category A
how does levothroxine (synthroid) affect warfarin
enhance
how does levothroxine (synthroid) affect catecholamines
enhanced
how does levothroxine (synthroid) affect digoxin
diminished/reduces
how does levothroxine (synthroid) affect insulin
reduces
synthroid will increase metabolic rate, increaing the amount of glucose molecules, reducing the efficency of insulin
drugs that increase effects of synthroid
Antidepressants
adrenergic antiasthmatic drugs
nasal decongestants
first signs of hyperthyroidism
jitteriness
tachycardia
insomnia
HTN
medications that affect thyroid function
antivirals in heptatis C
cardiac drug aminodarone
if synthroid dose is too low, what are the symptoms we can expect
bradycardia lethargy constipation excessive fatigue excessive sleeping
If synthroid dose is too high watch for
irritatibility palpitations tachycardia dairrhea tremors insomnia
thyroid storm
hypertensive
tachycardic
bulging eyes
hyperthyroid drugs
inhibits release of thyroid hormone
visual
SSKI: saturated solution of KI
Lugols solution
Propanolol (inderal) - also a beta blocker (chills them out)
biphosphonate SE
GI ulcerations
stomach acid
osteonecrosis of the jaw and hip bones
when giving GH exogenously what are some nursing considerations?
watch the blood sugar- hyperglycemia
what posterior pituitary hormone medication can I used for GI bleeding?
pitressin- a synthetic ADH
nursing consideration when using Evista*
no pain killers needed
estrogen also reduces pain
SE of SERMS (evista)
increased risk of GYN cancer
CI for monoclonal antibody use (denosumab)
immunosupressed
Which is the only drug for osteoporosis that increases bone formation?
SE?
Teriparatide (Forteo) which is Parathyroid hormone
SE: osteosarcoma
think: forteo is fortified
Patient teaching with osteoporosis
500 mg Calcium 2x a day
antacids w/ calcium
take these meds 2 hours apart: iron tetracycline ciprofloxacin phenytoin
Patient teaching: biphosphonates
6-8 oz water 30 min before food, fluid or other medciation
dont take calcium within 2 hours of biphosphonates
take meds in an upright position and do not lay down for 30 min (causes you to have gastric irritation form increased HCl
report new or worsening esophageal irritation
___ potentiates/increases power of digoxin, can be given in cardiac emergencies and situations
calcium supplement
What drugs regulate calcium and bone metabolism
lasix- helps void out calcium phosphate salts- replace calcium IVF normal saline- flush out calcium corticosteriods steriods
how does phosphate salts regulate calcium and bone metabolism
calcium replaces
Hormone replacement therpay risk***
increases risk of endometrial and ovarian cancer
Drugs that reduce effectivness of estrogen
really smelly and rotten
rifampin
st johns wort
antiepileptic agents
ritonavir
Drugs whose effects are decreased by estrogens
Warfarin
insulin
Drugs whose effects are increased by estrogens
those dudes cant trick
Theophylline
diazepam
chlordiazepoxide
tricyclic antidepressants
ACTH stimulates production of
released from
corticosteriods in the adrenal cortex
anterior pituitary
GH stimulates
body cells
released from anterior pituitary
corticotropin stimulates
released from
adrenal cortex
