AntiCancer

Question 1

Characteristics of neoplastic cells

Answer 1

persistent proliferation
metastases
immortality
invasive growth

Question 2

how should chemotherapy be given

Answer 2

intermittent

Question 3

Nursing considerations when using Platinum compounds

Answer 3

Can damage the kidney- (keep pt well hydrated)
Emetogenic- vomitting
Peripheral Neuropathy
Bone marrow suppression
Ototoxicity- Tinnitus

Question 4

What are/What is the action of antimetabolites

Answer 4

folic acid and pyrimidine, purine analogs

these things enter the cell by acting like basic nutrients

think: the name itself should be a hint. AntiMetabolites

Question 5

Which drug requires leucovarian as a “leucovarian rescue”?

what type of drug is it?

Answer 5

Methrotrexate (Rheumatrex)

which is a antimetabolite

Question 6

Hypomethylating agent drug action

Answer 6

DNA synthesis inhibition

Question 7

What drug can i give for conditions such as myelodysplastic syndrome, leukemia, multiple myeloma?

Answer 7

hypomethylating agent
Azacitidine (Vidaza)

hint: it stops these rapidly producing cells from DNA synthesis inhibition

Question 8

Which drug prevents DNA replication

Answer 8

Azacitidine (Vidaza)

Question 9

SE of anthracyclines

versus nonanthracyclines

Answer 9

anthracyclines:
severe bone marrow suppression
cardiac damage

nonanthracyclines:
no cardiac injury but bleomycin is toxic to lungs

Question 10

SE of bleomycin

type of drug is bleomycin?

Answer 10

toxic to lungs
(no cardiac injury)

its a nonanthracycline

Question 11

what kind of drug can I give for estrogen sensitive breast cancers?

Answer 11

SERMS

affect estrogen positive receptor cells

Question 12

anti estrogen action

Answer 12

block estrogen and dont allow it to have its growth-promoting effects

Question 13

when can serms be used

Answer 13

before tx
after tx
also, as a prevention

Question 14

What is the gold standard for high risk women for breast cancer

Answer 14

tamoxifen (nolavdex)

Question 15

SE of tamoxifen (Nolavdex)

What is the risk of taking this drug?

Answer 15

hot flashes
fluid retention
menstrual irregularities

(“because its changing the estrogen environment”)

risk= DVT

Question 16

what population group is the drug Tamoxifen for?

Answer 16

menstruating women, under age 60

Question 17

what kind of drug can I use on post menopausal women?

Answer 17

Aromatse inhibitors:
which would be:
anastrozole (Arimidex)
Letrozole (Femara)

cylindependent kinase inhibitor:
Oalociclib (vibrance)

Question 18

SE of aromatase inhibitors

Answer 18

musculoskeletal pain

types of aromatase inhibitor: arimidex and femur

Question 19

What are the name of the biphosphonates that are given to women who have breast cancer, to treats osteoporosis

Answer 19

Zoledronate (Zometa)
Pamidronate (Aredia)
Denosumab (Xgeva)

hint: ZAX abbreviation
* these drugs are NOT given to treat breast cancer, only osteoporosis (raman stressed)

Question 20

Prostate cancer: Drug that enhances testosterone?

Answer 20

Leuprolide (eligard)

hint: guarding the manhood :)

Question 21

drug that is given for an initial prostate tumor flare

Answer 21

leuprolide (eligard) GnRH agonists

hint: guarding the manhood :)

Question 22

Drug that blocks testosterone for prostate cancer

Answer 22

Degarelix (firmagon) - GnRH antagonists

hint: a FIRM block of testosterone

Question 23

Ketoconazole use

Answer 23

Anti-fungal

also lowers testosterone

Question 24

What are the names of the progestins used to treat cancer

Answer 24

Medroxyprogesterone (Depo-Provera)
Megestrol acetate (Megace)

Question 25

what can i use as a vitamin A supplment?

Answer 25

retinoids

Question 26

used for endometrial and breast cancer

Answer 26

depo-provera

Question 27

endometrial and renal cancer

Answer 27

magace