Endocrine Flashcards

0
Q

Four chemical classifications of hormones

A

Amines
Proteins/polypeptides
Glycoproteins
Steroids

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1
Q

Amines

  • made of
  • organs secreted from
  • polarity
  • activation mechanism
A

Amino acids- tyrosine and tryptophan

Adrenal medulla, thyroid, pineal

Polar

2nd messenger (Except thyroid hormone!)

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2
Q

Glycoproteins

Structure
Polarity
Activation mechanism

A

Protein bound to one or more carbohydrate groups

Polar

2nd messenger

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3
Q

Steroids

Derived from
Polarity
Activation mechanism

A

Cholesterol

Enzyme cleaves side chain

Nonpolar

Direct

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4
Q

Prohormone

A

Relatively inactive precursor hormones made in the endocrine cells

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5
Q

Pre-hormones

A

Normal secretions of an endocrine gland that must be converted to other derivatives by target cells in order to be active

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6
Q

Classes of actions of hormones

A

Permissive, synergistic, antagonistic

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7
Q

Synergistic

A

Two or more hormones work together to produce a particular result

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8
Q

Permissive

A

When a hormone enhances the responsiveness of a target organ to the other hormone or increases activity of other hormone

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9
Q

Which hormones bind directly to receptors in nucleus

A

Nonpolar

Steroids and thyroid hormones

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10
Q

Which hormones bind to receptors on outer surface of plasma membrane

How do these hormones create a response

A

Polar

Second messenger system

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11
Q

Dimerization

A

Process of two receptor units coming together at the two half sites

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12
Q

Describe thyroid hormone activation

A

T4 carried by carrier protein crosses plasma membrane. T4 is converted to T3 which binds to a protein and crosses nuclear membrane. T3 receptor forms a hetero dimer with retinoic acid receptor. transcription to mRNA occurs enabling protein production

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13
Q

Describe cyclic AMP mechanism

A

Hormone binds to a receptor and releases G proteins. G proteins binds to adenylate cyclase which converts ATP into cAMP. CAMP activates protein kinases. Protein kinase is transfer phosphate groups to other enzymes, affecting activity

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14
Q

Six hormones released from the anterior pituitary

A

ACTH, TSH, GH, FSH, PRL, LH

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15
Q

Growth hormone

Action, regulators

From

A

Promote protein synthesis and growth; lipolysis and increased blood glucose

Inhibited by somatostatin, stimulated by Growth hormone releasing hormones

Ant pit

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16
Q

Follicle stimulating hormone

Actions and regulators

From

A

Promotes gamete production and stimulates estrogen production in females

Stimulated by GnRH, inhibited by sex hormones

17
Q

Prolactin – actions, from, regulator

A

Promotes milk production in the lactating females

Prolactin inhibiting hormone

Ant pit

18
Q

Luteinizing hormone- actions, regulators, from

A

Stimulates sex hormone secretion. Stimulated by GnRH inhibited by sex steroids

Ant pit

19
Q

Adrenocorticotropic hormone – actions regulators, from

A

Stimulates secretion of glucocorticoids. Stimulated by corticotropin releasing hormone and inhibited by glucocorticoids

Ant pit

20
Q

Thyroid stimulating hormone – actions, regulators, from

A

Stimulates secretion of thyroid hormones. Stimulated by thyrotropin releasing hormone inhibited by thyroid hormone. From Ant pit

21
Q

Anterior lobe of pituitary gland

A

Adenohypophysis

22
Q

Posterior lobe of the pituitary gland

A

Neurohypophysis

23
Q

Hormones secreted by posterior pituitary

A

ADH and oxytocin

24
Oxytocin– action
Milk let down
25
Hormones secreted by the hypothalamus
CRH, GnRH, PIH, somatostatin, TRH, GHRH
26
Adrenal cortex secretions categories
Glucocorticoids, mineralocorticoids, sex steroids
27
Glucocorticoids – actions, example, zone
Help regulate energy balance, inhibit information, suppress immune function. Cortisol. Zona fasciculata
28
Mineralocorticoids – action, example, zone
Regulate sodium and potassium balance, aldosterone, zona glomerulosa
29
Hormones secreted by thyroid gland
T4 or thyroxine, T3, and calcitonin
30
Parathyroid hormone – action
Promotes rise in blood calcium levels
31
Actions of T3 and T4
Stimulate protein synthesis, promote maturation of the nervous system, and increased rate of cellular respiration
32
Mechanism of goiter
Absence of iodine leads to inability to produce T3 and T4. Lack of a negative feedback results in higher levels of TSH secretion resulting in abnormal growth of thyroid
33
Insulin – action, organ secreted from, type of cell secreted from
Lowers blood glucose and stimulates production of glycogen, fat, and protein (opens up cells for absorption). Secreted by pancreatic islets and beta cells
34
Glucagon – actions, organ secreted from, cell secreted from
Raises blood glucose by stimulating breakdown of the liver glycogen, promotes like a lysis, and formation of Ketone bodies. Secreted by pancreatic islets, and alpha cells
35
Melatonin- gland and function
Secreted from pineal gland. involves promotion of sleep
36
Which cells secrete testosterone and other androgens
leydig
37
Which cells secrete estrogen
Granulosa
38
What secretes progesterone and also estrogen
Corpus luteum
39
Autocrine regulation description
Regulate same cells in the same cell type in same tissue of same organ
40
Paracrine regulation description
Regulate and neighboring tissue of different type of tissue in same organ
41
Steroid hormone synthesis
If anyone could tell me what the fucks going on here would be convenient