endocrine

Question 1

describe congenital adrenal hyperplasia

Answer 1

autosomal recessive causing excess of sex steroids with hyperplasia of both adrenal glands

Question 2

what causes congenital adrenal hyperplasia

Answer 2

deficiency in 21 hydrolyse

Question 3

symptoms of congenital adrenal hyperplasia

Answer 3

low aldosterone, low cortisol, high androgens

Question 4

what defines precocious puberty

Answer 4

in females before 8 and males before 9
more likely to be pathology in males

Question 5

causes of central precisous puberty

Answer 5

genetic
hypothyroid
CNS abnormalities

Question 6

management of precisous puberty

Answer 6

GnRH analogues

Question 7

peripheral causes of precious puberty

Answer 7

adrenal, ovarian, testicular

Question 8

signs of kallman syndrome

Answer 8

failure of GnRH secreting neutrons to migrate to the hypothalamus giving poor GnRH secretion

signs:
puberty delay
facial defromities
CNS problems
abnormal finger/toes bones
patient typically tall

sex hormone replacement therapy