Endocrine

Question 1

Which antibodies are associated with DMI?

Answer 1

HLA-DR3 and HLA-DR4 antigens and antibodies against GAD65 are found in 80% of patients with DMI

Question 2

What are the criteria for metabolic syndrome and how many are required to make the diagnosis?

Answer 2

Three of the following criteria are required —
waist circumference > 40 in men, 35 in females
BP >130/80
triglycerides >150
fasting blood glucose >100
HDL <40 in men, <50 in women

Question 3

What is a normal TSH?

Answer 3

0.45-4.5

Question 4

What is a normal T3?


Answer 4

4-8

Question 5

What is a normal T4?

Answer 5

10-20

Question 6

What is the most common cause of hypothyroidism?

Answer 6

Hashimoto’s Thyroiditis

Question 7

What is the most common cause of hyperthyroidism?


Answer 7

Graves Disease

Question 8

What medication should be avoided in patients with thyroid storm?

Answer 8

ASA

Question 9

What is the conversion of PO to IV synthroid?

Answer 9

IV synthroid is equal to half the oral dosing so 100mcg of oral synthroid is equivalent to 50mcg IV synthroid

Question 10

What is the diagnostic test of choice to evaluate primary adrenal insufficiency (Addison’s Disease)?

Answer 10

Addison’s Disease (primary adrenal insufficiency) is determined by an ACTH (cosyntropin) stimulation test which would not result in an increase in serum cortisol

Question 11

What condition can cause nephrogenic DI?

Answer 11

pyelonephritis

Question 12

How do you differentiate central DI from nephrogenic DI?

Answer 12

Central DI is responsive to DDAVP while nephrogenic DI is not

Question 13

What is the outpatient treatment for central DI?

Answer 13

intranasal DDAVP

Question 14

What does diagnostic testing for pheochromocytoma consist of?

Answer 14

plasma free metanephrines, urine catecholamines, metanephrine, VMA, and creatinine

Question 15

What endocrine disorder is characterized by hyponatremia, hypoglycemia, hyperkalemia, elevated ESR, lymphocytosis?

Answer 15

Addison’s Disease

Question 16

A plasma cortisol <5 at 0800 is suggestive of what condition?

Answer 16

Addison’s Disease

Question 17

What is the diagnostic test of choice for Addison’s Disease?

Answer 17

cosyntropin test

Question 18

What endocrine disorder is characterized by hypernatremia, hyperglycemia, hypokalemia, glycosuria, leukocytosis, and increased serum ACTH?

Answer 18

Cushing’s Syndrome

Question 19

An elevated plasma cortisol level at 0800 is suggestive of what condition?

Answer 19

Cushing’s Syndrome

Question 20

What is the diagnostic test of choice for Cushing’s Syndrome?

Answer 20

dexamethasone suppression test

Question 21

What is the drug of choice for the treatment of pheochromocytoma pre-operatively?

Answer 21

IV Phentolamine

Question 22

What is the drug of choice for the treatment of pheochromocytoma post-operatively?

Answer 22

PO phenoxybenzamine

Question 23

What ethnicity most likely to have DM2 but not seek treatment?

Answer 23

Hispanic

Question 24

What endocrine disorder is characterized by hyponatremia, decreased serum osmo < 280, increased urine osmo > 100, increased urine Na > 20?

Answer 24

SIADH

Question 25

What endocrine disorder is characterized by hypernatremia, elevated BUN/Cr, increased serum osmo > 290, decreased urine osmo < 100, decreased urine specific gravity < 1.005

Answer 25

DI