Endocrine Flashcards
Which antibodies are associated with DMI?
HLA-DR3 and HLA-DR4 antigens and antibodies against GAD65 are found in 80% of patients with DMI
What are the criteria for metabolic syndrome and how many are required to make the diagnosis?
Three of the following criteria are required —
waist circumference > 40 in men, 35 in females
BP >130/80
triglycerides >150
fasting blood glucose >100
HDL <40 in men, <50 in women
What is a normal TSH?
0.45-4.5
What is a normal T3?
4-8
What is a normal T4?
10-20
What is the most common cause of hypothyroidism?
Hashimoto’s Thyroiditis
What is the most common cause of hyperthyroidism?
Graves Disease
What medication should be avoided in patients with thyroid storm?
ASA
What is the conversion of PO to IV synthroid?
IV synthroid is equal to half the oral dosing so 100mcg of oral synthroid is equivalent to 50mcg IV synthroid
What is the diagnostic test of choice to evaluate primary adrenal insufficiency (Addison’s Disease)?
Addison’s Disease (primary adrenal insufficiency) is determined by an ACTH (cosyntropin) stimulation test which would not result in an increase in serum cortisol
What condition can cause nephrogenic DI?
pyelonephritis
How do you differentiate central DI from nephrogenic DI?
Central DI is responsive to DDAVP while nephrogenic DI is not
What is the outpatient treatment for central DI?
intranasal DDAVP
What does diagnostic testing for pheochromocytoma consist of?
plasma free metanephrines, urine catecholamines, metanephrine, VMA, and creatinine
What endocrine disorder is characterized by hyponatremia, hypoglycemia, hyperkalemia, elevated ESR, lymphocytosis?
Addison’s Disease
A plasma cortisol <5 at 0800 is suggestive of what condition?
Addison’s Disease
What is the diagnostic test of choice for Addison’s Disease?
cosyntropin test
What endocrine disorder is characterized by hypernatremia, hyperglycemia, hypokalemia, glycosuria, leukocytosis, and increased serum ACTH?
Cushing’s Syndrome
An elevated plasma cortisol level at 0800 is suggestive of what condition?
Cushing’s Syndrome
What is the diagnostic test of choice for Cushing’s Syndrome?
dexamethasone suppression test
What is the drug of choice for the treatment of pheochromocytoma pre-operatively?
IV Phentolamine
What is the drug of choice for the treatment of pheochromocytoma post-operatively?
PO phenoxybenzamine
What ethnicity most likely to have DM2 but not seek treatment?
Hispanic
What endocrine disorder is characterized by hyponatremia, decreased serum osmo < 280, increased urine osmo > 100, increased urine Na > 20?
SIADH
