Emergency Medicine Flashcards
Rapid primary survey components
Airway (C-spine) Breathing and ventilation Circulation (pulse, hemorrhage) Disability (neurological status) Exposure (complete) and Environment (temperature control)
- continually reassess during secondary survey
- if change in hemodynamic/neurological state, return to primary survey
If cardiac arrest, primary survey changes to
CABs
Airway in rapid primary survey
Immobilize with collar
Assess ability to breathe and speak
Reassess frequently
Assess facial fx/edema/burn
Basic airway management
Protect C-spine
If C-spine injury not suspected, head tilt
If C-spine injury suspected, jaw thrust
Sweep and suction
Temporizing measures
If gag reflex present (conscious): nasopharyngeal airway
If gag absent (unconscious): oropharyngeal airway
Rescue devices: laryngeal mask airway, Combitube
Last resort: transtracheal jet ventilation
Definitive airway Mx
ETT intubation + in-line stabilization of C-spine
- Preferred: orotracheal +/- RSI
- If conscious: nasotracheal better tolerated
- no 100% protection agains aspiration
- nasotracheal relatively contraindicated in basal skull fx
If unable to intubate: surgical airway
*cricothyroidotomy
Contraindications to intubation
Supraglottic/glottic pathology
Medications that can be delivered via ETT
Naloxone Atropine Ventolin (salbutamol) Epinephrine Lidocaine
If trauma requiring intubation but no immediate need what’s the next step?
C-spine x-ray
If positive:
Fiberoptic ETT
Nasal ETT
RSI
If negative: Oral ETT (+/- RSI)
Breathing in rapid primary survey
Look: mental status, color, chest movement
Listen: auscultate (signs of obstruction such as stridor), breath sounds, symmetry of air entry, air escaping
Feel: tracheal shift, chest wall crepitus, flail segment, sucking chest wound, emphysema
Objective measures for assessment of breathing
Rate, oximetry, ABG, A-a gradient
Mx of breathing
In order of increasing FiO2: Nasal prongs Simple face mask Nonrebreather mask CPAP/BiPAP
If inadequate ventilation:
Bag-Valve mask
CPAP
Class I hemorrhagic shock
<750 ml (<15% of blood volume) PR <100 BP: Normal RR: 20 Capillary refill: Normal U/O: 30cc/h Fluid replacement: Crystalloid
Class II hemorrhagic shock
750-1500cc 15-30% PR > 100 RR 30 BP Normal Capillary refill decreased U/O 20cc/h Fluid replacement: crystalloid
Class III
1500-2000 30-40% PR >120 BP decreased RR 35 CR decreased U/O 10 cc/h Fluid: crystalloid+ blood
Class IV
>2000 >40% PR>140 BP decreased RR > 45 CR decreased U/O none Fluid crystalloid + blood
Indications for intubation
Unable to protect airway (GCS <8, airway trauma)
Inadequate oxygenation with spontaneous respiration (O2 sat <90% with 100% O2, rising pCO2)
Impending airway obstruction: trauma, overdose, airway burns, CHF, asthma, COPD, anaphylaxis, angioedema, expanding hematoma
Anticipated transfer of critical patient
Mx of hemorrhagic shock
Clear airway/breathing
Direct pressure on external wounds
Start 2 large bore IVs (14-16)
Run 1-2 L bolus of IV normal saline/ Ringer’s lactate
If no response/ continued bleeding, pRBC (crossmatched or O- for women, O+ for men)
FFP, Plt, Tranexamic in eatly bleeding
Cosider common sites of internal bleeding (surgical intervention)
Disability in primary survey
Assess LOC (GCS) And Eyes: Pupils (size, symmetry, reactivity to light) Extraocular movements/nystagmus Fundoscopy (papilledema, hemorrhage)
Decreased LOC + reactive pupils
Metabolic cause
Or
Structural cause
Decreased LOC + non-reactive pupils
Structural cause
GCS use
For use in trauma pt (less meaningful for metabolic coma)
Indicator of ”severity” of injury and neurosurgical “prognosis”
Needs to be repeated (changes more relevant than absolute number)
GCS in intubated pt:
Reported out of 10 + T
The GCS used for prognosis determination
Best post-resuscitation GCS
Eye in GSC
Eyes open
4: spontaneously
3: to voice
2: to pain
1: none
Verbal response in GCS
5: Answers questions properly
4: Confused and disoriented
3: Inappropriate words
2: incomprehensible sounds
1: none
Motor response in GCS
6: Obeys commands
5: localizes to pain
4: Withdraws from pain
3: decorticate
2: decerebrate
1: none
Exposure/Environment in primary survey
Assess entire body Log roll DRE Keep pt warm (blanket, radiant heat) Warm IV fluids/blood Keep provider safe
3:1 rule for saline crystaloids
30% remains in IV space, so give 3x estimated blood loss
Fluid resuscitation
Bolus: until HR decreases, U/O increases, pt stabilizes
Then Maintenance: 4:2:1 rule 0-10 kg: 4 cc/kg/h 10-20 kg: 2 cc/kg/h Remaining wt: 1 cc/kg/h
+ ongoing losses and deficits ( 10% of body wt)
If unilateral dilated, non-reactive pupil, DDx?
Focal mass
Epidural hematoma
Subdural hematoma
Resuscitation components
Done concurrently with primary survey
Attend to ABC
Manage life-threatening problems as they are identified
Vital signs q5 to 15 minutes
ECG, BP, O2 monitoring
Foley cath and NG if indicated
Tests: CBC, lytes, BUN, Cr, glucose, amylase, INR/PTT, B-hCG, toxicology screen, cross and type
Contraindications to foley insertion
Blood at urethra meatus
Scrotal hematoma
High-riding prostate on DRE
NG tube contraindications
Basal skull fracture
Significant mid-face trauma
Airway for CPR
Head tilt-chin lift
For all ages
(If C-spine stable)
Breaths for CPR
2 breaths at 1 s/breath
Stop once see chest rise
Foreign-body airway obstruction
> 8 y: abdominal thrust
<1 y: back slaps, chest thrusts
Compression landmarks in CPR
> 1 y: chest centre, between nipples
<1 y: just below nipple line
Compression method in CPR
> 8y: 2 hands, 2-2.4 inches
<8y: 1/3 to 1/2 the depth of the chest
1-8 y: 2 or 1 hand
<1 y: 2 fingers or thumbs
Compression rate in CPR
100-120/ min
Allow complete chest wall recoil
Compression to ventilation ratio
30 compression to 2 ventilations
Defibrillation
If sudden witnessed collapse: immediate AED
If unwitnessed arrest: compression (5 cycles/2 min), then AED
If children/infant: manual defibrillator preferred (but use adult dose if not available)
When is secondary survey done?
Once patient is hemodynamically and neurologically stabilized
Secondary survey components
Hx
Full physical exam
X-rays (C-spine,chest, pelvis),
Consider T-spine and L-spine if indicated
History taking during secondary survey
SAMPLE S: signs and symptoms A: allergies M: medications P: past medical history L: last meal E: events related to injury
Physical exam during secondary survey
Head and neck: palpation of facial bones, scalp
Chest:
Inspect for: 1 midline trachea 2. Flail segment And associated hemothorax, pneumothorax and contusions
Auscultate lung fields
Palpate: Subcutaneous emphysema
Abdomen:
Assess for: peritonitis, distention, evidence of intra-abdominal bleeding
DRE for: GIB, high riding prostate, anal tone
MSK:
Extremities: swelling, contusion, deformity, tenderness, ROM
pulses (Doppler probe), sensation in injured limbs
Log roll and palpate thoracic and lumbar spines
Palpate iliac crest, pubic symphysis, assess pelvic stability (lateral, AP, vertical)
Neuro:
*GCS
*Full cranial nerve exam
*Alterations of rate and rhythm of breathing
*Spinal cord integrity
If conscious: distal sensation and motor function
If unconscious: response to painful or noxious stimulus applied to extremities
Initial imaging during secondary survey
Non-contrast CT head/face/C-spine
CXR
FAST or CT abd/pel (if stable)
Pelvis x-ray
Signs of increasing ICP in trauma patient
Deteriorating LOC Deteriorating respiratory pattern Cushing reflex Lateralizing CNS signs Seizures Papilledema (late) N/V and headache
Golden hour in trauma
4-6 h
Height of fall considered high risk injury
> 12 ft (3.6 m)
Typical vault skull fx
Linear: temporal bone, middle meningeal artery area
The most common cause of epidural hematoma
Linear skull vault fx in middle meningeal artery area
Typical basal skull fx
Floor of anterior cranial fossa
Longitudinal
Best method if diagnosing basal skull fx
Clinical Dx superior to CT
High risk injuries in MVC
Ejection from vehicle
Motorcycle collisions
Vehicle versus pedestrian crashes
Fall from height Ford and 12 feet
Concussion
Mild traumatic brain injury (diffuse)
Alteration in mental status (must be < 30min)
Initial GCS (must be 13-15)
Post-traumatic amnesia (must be less than 24 h)
Hallmarks: confusion, amnesia immediately after trauma or minutes later
Diffuse axonal injury
Mild: coma 6-24 h, possibly lasting deficit
Moderate: coma >24h, little/no signs of brainstem dysfunction
Severe: coma > 24 h, frequent signs of brainstem dysfunction
Focal brain injuries
Contusion
Intracranial hemorrhage
Cushing response to increased ICP
Bradycardia
HTN
irregular respirations
Traumatic brain injury severity
Mild: GCS:13-15
Mod: 9-12
Severe: 3-8
Significant anisocoria in trauma
> 1mm in pt with altered LOC
Hx in assessment of brain injury in trauma pt
Pre-hospital status
Mechanism of injury
PEx in assessment of brain injury in trauma pt
C-spine: assume injured V/S: shock (infants), Cushing response LOC Pupils: size, anisocoria, response to light Lateralizing signs (motor/sensory) Reassess frequently
Investigations in assessment of brain injury in trauma pt
CBC, lytes, toxicology screen, PTT/INR, glucose
CT of head and neck
C-spine imaging
Goal of Mx of brain injury in ED
Reducing secondary injury by:
Avoiding hypoxia, ischemia, decreased cerebral perfusion pressure, seizure
Head injury Mx in ED
General: ABC Intubate, prevent hypercarbia sBP > 90 Treat other injuries Neurosurgical consultation Seizure Tx/Prophylaxis: BDZ, Phenytoin, phenobarbital
Treat suspected raised ICP
Treatment of raised ICP
Intubate
Calm(sedate)
Paralyze (if agitated)
Hyperventilate ( 100% O2, to pCO2 of 30-35)
Elevated bed head (20 degrees)
Adequate BP
Diuresis with mannitol 1g/kg, infused rapidly
Contraindications to manittol
Shock
RF
Mx of minor head injuries not requiring admission
24 h head injury protocol to competent caregiver
F/U with neurology
Indications of CT had in minor head injury
GCS < 15 at 2 h after injury Suspected depressed/open skull fx Any sign of basal skull fx Vomiting > 1 episode Age 65 or higher
Amnesia before impact > 30 min Dangerous mechanism (fall > 3 foot, ejected occupant, pedestrian struck)
Definition of minor head injury
Witnessed loss of consciousness, definite amnesia, or witnessed disorientation in a patient with a GCS score of 13-15
Warning signs of severe head injury
GCS<8
Deteriorating GCS
Unequal pupils
Lateralizimg signs
Signs of mild traumatic brain injury
Somatic:
Headache, sleep disturbance, N/V, blurred vision
Cognitive dysfunction:
Attentional impairment, reduced processing speed, drowsiness, amnesia
Emotion and behavior:
Impulsivity, irritability, depression
Signs of severe concussion
Seizure, bradycardia, hypotension, sluggish pupils
Tx of mild traumatic brain injury
Close observation and F/U
Hospitalize if:
*abnormal CT
*normal CT with GCS<15, bleeding diathesis, seizure
Early rehab
Pharmacological Mx of pain, depression, headache
Return to play guidline
C-spine collar indications
Midline tenderness Neurological symptoms or signs Significant distracting injuries Head injury Intoxication Dangerous mechanism Hx of altered LOC
When to assume cord injury?
Fall > 12 ft
Deceleration injury
Blunt trauma to head, beck or back
The most important film of cervical spine
Lateral cervical x-ray
Indication of MRI in traumatic brain injury
If worsening symptoms despite normal CT
Spinal cord injury Hx
Mechanism Previous deficits SAMPLE neck pain Paralysis/weakness Paresthesia
Spinal cord injury PEx
ABC
Abdomen:
Ecchymosis, tenderness
Neurological
Spine:
Palpate C-spine, log roll and palpate T-spineand L-spine, assess rectal tone
Extremities:
Capillary refill, if calcaneal fx, suspect thoracolumbar imjury
Investigations for spine injury
CBC, lytes, Cr, glucose, INR/PTT, cross/type, toxicology screen
Imaging:
C-spine x-ray series (AP, lateral, odontoid view)
Thoracolumbar x-rays (AP, lateral)
Level of injury for cauda equina syndrome
Below T10
Cauda equina symptoms
Incontinence Anterior thigh pain Quadriceps weakness Abnormal sacral sensation Decreased rectal tone Variable reflexes
Indications for spine imaging
C-spine injury
Unconscious patient with appropriate mechanism of injury
Neurological symptoms or findings
Deformities that are palpable when patient is log rolled
Back pain
Bilateral calcaneal fractures due to fall from height
Consider CT for subtle bone injuries, MRI for soft tissue injuries if appropriate
The canadian C-spine rule:
Radiology performed if:
Any of:
- age > 65
- dangerous mechanism
- paresthesia in limbs
Or
None of: Simple rear-end MCV Sitting in ED Ambulatory at any time Delayed onset of neck pain
Or
Not able to actively rotate neck > 45 degrees
Insications for C-spine X-ray
Midline neck pain Numbness or paresthesia Presence of distracting pain Head injury Intoxication Loss of consciousness Past history of spinal mobility disorder Posterior neck spasm Tenderness or crepitus Any neurologic deficit Autonomic dysfunction Altered mental status
Indications for C-spine CT scan
Inadequate plain film survey
Suspicious plain film findings
To better delineate injuries seen on plane films
Any clinical suspicion of Atlanto-axial subluxation
High clinical suspicion of injury despite normal x-ray
To include C1-C3 when head city is indicated in head trauma
If normal C-spine films but abnormal neurological exam
Perform an MRI
C-spine cleared if normal
If normal C-spine films but neck pain
Order flexion/extension films
If normal, C-spine cleared
If abnormal, remain immobilized and consult spine service
Mx of cord injury
Immobilized Evaluate ABC Treat neurogenic shock (maintain SBP> 100) NG Foley High-dose steroid within 6-8h Complete imaging of the spine Consult spine service Continually re-assessed high cord injuries Watch for respiration if cervical cord injury Warm blanket Trendelenburg position Volume infusion Consider vasopressors
Cervical cord injury and respiration
C5-T1: abdominal breathing
Higher level injury: May require intubation and ventilation
Unable to rule out dens fx by odontoid view
Repeat view Or CT Or Plain film tomography
Physiologic spine subluxations
Children < 8y
C2 on C3
C3 on C4
Spino-laminal lines are maintained
Fanning of spinous processes
Posterior lugament disruption
Widening of predental space
3 mm or higher in adults
5 mm or higher in children
Suggests C1 or C2 injury
Anterior/ posterior wedging of intervertebral disc spaces
Vertebral compression
Normal retropharyngeal width
<7 mm at C1-C4
Wide in children <2 y on expiration
Normal retrotracheal space width
<22 mm at C6-T1
<14 mm in children < 5 y
Neurogenic shock level
T6 or higher Within 30 min Loss of vasomotor tone, SNS tone Lasts up to 6 wk Hypotension, bradycardia, poikilotherma
Spinal shock
Absence of all voluntary and reflex activities below level of injury
No sensation
Flaccid paralysis
Lasts days to months
Autonomic dysreflexia
Level T6 or higher Chronic phase of spinal cord injuryg Pounding headache Nasal congestion Apprehension Anxiety Visual changes Dangerously increased SBP or DBP
Triggers
Bladder distention, UTI, kidney stone
Fecal impaction, bowel distension
Tx: monitoring, BP control, then: underlying
Airway obstruction investigation and Mx
Primary survey
Inv: none
Mx:
Definitive airway management
Remove foreign body if visible with laryngoscope prior to intubation
Tension pneumothorax investigations and management
Primary survey
Investigation: none
Management:
Needle Thoracostomy, large bore needle, 2nd ICS, mid-clavicular line
Then: Chest tube in 5th ICS, anterior axillary line
Open pneumothorax Mx
Primary survey
Air-tight dressing sealed on 3 sides
Chest tube
Surgery
Inv: decreased pO2 on ABG
Massive hemothorax Mx
Primary survey
>1500 cc blood
Only able to do supine CXR (entire lung radioopaque)
Mx: Restore blood volume Chest tube Thoracotomy if: >1500 total blood loss > 200cc/h continued drainage
Flail chest Mx
Primary survey
ABG: decreased pO2, increased pCO2
CXR: rib fx, lung contusion
Mx: O2+ fluid+ pain control
Positive pressure ventilation
+/- intubation and ventilation
Cardiac tamponade Mx
Primary survey
Echo
FAST
Mx: IV fluid
Pericardiocentesis
Open thoracotomy
Pulmonary contusion Mx
Secondary survey
CXR: area of opacification of lung within 6 h
Mx: Adequate ventilation Monitor with: ABG, oximeter, ECG Chest physiotherapy If severe: positive pressure ventilation
Ruptured diaphragm Mx
Secondary survey CXR: abn diaphragm/ lower lung fields NGTube CT Endoscopy
Mx: laparotomy
Esophageal injury
Secondary survey
CXR: mediastinal air
Esophagogram
Flexible esophagoscopy
Mx: all require repair (improved outcome if within 24h)
Aortic tear
Secondary survey CXR CT TEE aortography
Mx: thoracotomy
Blunt myocardial injury
Secondary survey
ECG: dysrhythmias, ST changes
If normal ECG and hemodynamics, pt never gets dysrhythmia
Mx: O2
Antidysrhythmic
Analgesic
Aortic tear on X-ray
Depressed left mainstem bronchus Pleural cap Wide mediastinum (The most consistent feature) Hemothorax Indistinct aortic knuckle Tracheal deviation to right Esophagus (NG) deviated to right
Penetrating neck trauma
Do not explore except in OR
If injury deep to platysma: angiography, contrast CT, surgery
Do not clamp structures
Do not probe
Do not insert NG
Do not remove weapon/impaled object
Triad of larynx injury
Hoarseness
SQ emphysema
Palpable fx
Other: hemoptysis
Dyspnea
Dysphonea
Inv in larynx injury
CXR
CT
Arteriography (if penetrating)
Management of larynx injury
Airway: manage early because of Edema
C-spine protection
Surgery: tracheotomy vs repair
Injury to trachea or bronchus
Dyspnea, hemoptysis
SQ air
Hamman’s sign: Crunching sound synchronous with heartbeat
CXR: mediastinal air, persistent pneumothorax or persistent air leak after chest tube inserted for pneumothorax
Mx: if > 1/3 circumference, surgical repair
The most common solid organ injury in blunt abdominal trauma
Spleen
Liver is the second most common
The most common are organ injury in penetrating abdominal trauma
Liver
And hollow organs
Investigations in abdominal trauma
CBC Lytes Coagulation Cross/type Glucose Cr CK lipase Amylase Liver enzyme ABG blood EtOH B-HCG U/A Toxicology
Indication of foley in abdominal trauma
Unconscious
Patient with multiple injuries who cannot void spontaneously
Indications for NG tube in abdominal trauma
To decompress the stomach and proximal small bowel
Contra: face/skull base fx
Seatbelt abdominal injuries
Retroperitoneal duodenal trauma
Intraperitoneal bowel transection
Mesentric injury
L-spine injury
X-ray and abdominal trauma
CXR Pelvis C-spine Thoracic Lumbar
CT scan in abdominal trauma
Most specific test
Cannot be used if hemodynamic instability
Diagnostic peritoneal lavage
Most sensitive test for interperitoneal bleed
Cannot test for retroperitoneal bleed or diaphragmatic ruptures
Cannot distinguish lethal from trivial bleed
Results take up to one hour
FAST
Rapid <5min
False positive in ascites
Positive DPL
Gross blood > 10cc Bile Bacteria Foreign material RBC > 100,000/microliter WBC > 500 Amylase > 175 IU
Indications for abdominal imaging
Equivocal abdominal examination
Altered sensorium
Distracting injuries (head trauma, spinal cord injury resulting abdominal anesthesia)
Unexplained shock or hypotension
Patients with multiple trauma who must undergo general anesthesia
Fracture of lower ribs, pelvis, spine
Positive FAST
Management of blunt abdominal trauma
ABC
Fluid
Surgical: watchful waiting vs. laparotomy
If solid organ injury: decision based on hemodynamic stability not the specific injuries
If hemodynamically unstable or persistently high transfusion requirements: Laparotomy
If hollow organ injury: laparotomy
If low suspicion of injury: admit and observe for 24 h
Penetrating abdominal trauma Mx
ABC
Fluid
Local wound exploration under direct vision to determine peritoneal perforation
Except: thoracoabdominal region, back/flanks
If gunshot: always laparotomy
If shock: laparotomy
If peritonitis: laparotomy
If evisceration: laparotomy
If free air in abdomen: laparotomy
If blood in NG: laparotomy
If blood in foley: laparotomy
If blood on DRE: laparotomy
PEx in abdominal trauma
Inspection Palpation Auscultation NG Foley DRE
Intraperitoneal bladder rupture if:
Full bladder
Acute abdomen presentation
Extraperitoneal bladder rupture
From pelvic fx
Pelvis instability, suprapubic tenderness
Gross hematuria in abdominal trauma suggests:
Bladder injury
Investigations for GU teauma
Urethra: retrograde urethrography
Bladder: U/A, CT, urethrogram +/- retrograde cystoscopy +/- cystogram (dilated bladder, post-void
Ureter: retrograde ureterogram
Renal: CT (if stable hemodynamic), IVP
In case of gross hematuria
GU investigated from distal to proximal
Mx of renal trauma
Minor:
Conservative: bed rest, hydration, analgesic, AB
Major:
Admit
Conservative: frequent assessments, serial U/A +/- re-imaging
If hemodynamically unstable: surgery
If continued bleeding > 48h: surgery
If major urine extravasation: surgery
Renal pedicle injury: surgery
Penetrating wound: surgery
Major laceration: surgery
Infection: surgery
Renal artery thrombosis: surgery
Mx of ureter trauma
Ureterouretostomy
Mx of bladder trauma
Extraperitoneal:
If minor rupture, Foley x 10-14 d
If major rupture, surgical repair
Intraperitoneal:
Drain abdomen and surgical repair
Urethra trauma Mx
Anterior:
Conservative, if cannot void, Foley/suprapubic cystostomy and AB
Posterior: Suprapubic cystostomy (avoid cath) +/- surgical repair
Open fx management
Remove gross debris Irrigate Cover with sterile dressing OR: irrigation, debridement Control bleeding with pressure Splint AB Definitive surgical Mx within 6 h Tetanus prophylaxis Neurovascular status before and after reduction
Do not clamp
If vascular compromise in fx
Realign limb/ apply longitudinal traction
Reassess pulse with doppler
Surgical comsult
Pain out of proportion to injury
Esophageal rupture
Compartment syndrome
Ischemia of mesentry
Necrotizing fasciitis
Compartment syndrome Mx
Prompt decompression
Remove constrictive cast and dressings
+/- emergent fasciotomy
Anterior shoulder dislocation Mx
X-ray (lateral, fx?)
Reduction (traction, scapular manipulation)
Repeat x-ray
F/U with ortho
Nerve injury: lateral aspect of shoulder (axillary nerve), extensor of forearm (musculocutaneous)
Coll’s fx
X-ray: radial deviation, dorsal displacement
Scaphoid fx symptoms
Tenderness in anatomical snuffbox
Pain on scaphoid tubercle
Pain on axial loading of thumb
Scaphoid fx Mx
Negative X-ray: thumb spica splint, repeat x-ray in 1 wk +/- CT, bone scan
Positive x-ray: thumb spica splint x 6-8 wk, repeat x-ray in 2wk
Outpt F/U
Avulsion of the base of 5th metatarsal
Occurs with inversion injury
Supportive tensor or below knee walking cast x 3wk
Ankle radiograph series indications in malleolus trauma:
Pain in malleolar zone and any of:
Bony tenderness atposterior edge or tip of lateral malleolus
Or
Bony tenderness at posterior edge or tip of medial malleolus
Or
Inability to bear wt both immediately and in ED
Ankle radiograph series indications in midfoot trauma:
Pain in midfoot zone and any of:
Bony tenderness at base of 5th metatarsal
Or
Bony tenderness at navicular bone
Or inability to bear wt both immediately and in ED
Wounds requiring tetanus prophylaxis
Dirt, soil, feces, saliva contamination Puncture wound Avulsion Resulting from missile Crushing Burn Frostbite
Abrasion management
Clean thoroughly with brush
Local anesthetic antiseptic oint (if facial or complex abrasion
Tetanus prophylaxis
Acute treatment of contusions
RICE Rest Ice Compression Elevation
High risk factors for infection
Puncture Crush >12h Hand or foot Age> 50 Prosthetic joint/valve Immunocompromised
Suture size and duration
Face: 6-0 x 5d Joints: 3-0 x 10d Not joints: 4-0 x 7d Scalp: 4-0 x 7d Mucous membranes: absorbable
Laceration Mx
Tendon function against resistance Neurovascular status Clean Explore under local anesthesia X-ray or U/S if suspicion of foreign body or if suspect intra-articular involvement Disinfect skin Sterile techniques Analgesia +/- anesthesia Secure hemostasis Evacuate hematoma Debride non-viable tissue, remove hair and foreign body AB for prophylaxis Suture
Maximum dose of lidocain
With epinephrine: 7 mg/ kg
Without epinephrine: 5 mg/kg
Indications for prophylactic AB in lacerations
Animal bite
Human bite
Intra-oral lesions
Puncture wounds to the foot
Exception to perform suture
Presentation > 6-8 h Puncture wound Mammalian bite Crush injury Retained foreign body
The most important factor in decreasing wound infection risk is:
Early irrigation and debridement
Metabolic reasons of stomachache
Emergent:
DKA, Sickle cell crisis, toxin, addisonian crisis
Less emergent:
Lead poisoning, porphyria
Investigations in abdominal pain
ABC CBC Lytes BG BUN/Cr, U/A Liver enzymes, LFT Lipase Lactate, VBG ECG, troponins B-hCG AXR, CXR, U/S, CT
Pts with atypical presentations of abdominal pain
Very young
Elderly
Alcoholics
Immunocompromised
Peritoneal findings blunted if:
Old age
Pregnancy T3
Chronic CS use
Disposition of abdominal pain pt
Admit if:
Surgical abdomen, w/u of significant abdominal findings, need for IV AB or pain control
Discharge if: negative lab, negative imaging who improve clinically
Return if: fever, increasing pain, persistent vomiting
Most common cause of pelvic pain
Ruptured ovarian cyst
Acute pelvic pain inv
B-hCG
CBC, diff, lytes, BG, Cr, BUN, G&S, PTT/INR, U/A, vaginal/cervical swabs for C&S,
Abdominal/pelvis U/S
Doppler flow studies for ovarian torsion
Pelvic pain referral indications:
If requiring surgery
If requiring admission
If oncologic
Admit if: requiring surgery, IV AB/pain control
Discharge if: negative w/u, improving symptoms
Ovarian cyst Mx
If unruptured: analgesia, f/u
If ruptured but stable hemodynamic: analgesic and f/u
If unstable hemodynamic or significant bleeding: surgery
Preferred imaging modality and assessment of pelvic pain
U/S
Lethargy, Stupor, Coma
Lethargy: wakeful but decreased awareness and alertness
Stupor: unresponsive but rousable
Coma: unresponsive, not rousable to consciousness
Abrupt onset of coma suggests
CNS hemorrhage/ischemia
Cardiac cause
Onset of coma over hours to days
Progressive CNS lesion
Toxic
Metabolic
PEx in altered LOC
ABC LOC, eye examination vitals Cardiac/respiratory/abdominal exams Complete neurologic exam
Investigations for altered LOC
CBC Lytes BUN, Cr, U/A LFT Glucose INR/PTT Serum osmolality, VBG Troponins Serum EtOH, acetaminophen, salicylate CXR, CT head ECG, UTox
Finding suggestive of toxic or metabolic coma
Dysfunction at lower levels of the brain stem
Respiratory depression in association with an intact opera brainstem (equal and reactive pupils)
Extraocular movements and motor findings are symmetric or absent
Findings suggestive of structural coma
Lateralizing abnormalities
Lucid interval
Epidural hematoma
Universal antidotes
Thiamine 100 mg IV ( if Hx of EtOH or malnourished)
D50W IV 1 ampule (if hypoglycemic on fingerprick)
Naloxane 0.4-2 mg IV or IM (if opiate overdose suspected)
Toxic or metabolite causes of fixed dilated pupils
Anoxia Anticholinergic (atropine, TCA...) Methanol Cocaine Opioid withdrawal Amphetamine Hallucinogen
Toxic or metabolic causes of fixed constricted pupils
Opiates (except meperidine)
Cholinergics (organophosphates)
Metabolic/toxic causes of normal to dilated fixed pupils
Hypothermia
Barbiturates
Antipsychotics
Chest pain investigations
CBC, lytes, BUN, Cr, BG, PTT/INR, CK, troponins
ECG, CXR, CT
Mx of acute chest pain
ABC O2 Cardiac monitoring IV access Underlying, consultation Observation/monitoring if unknown cause
When to discharge a pt with acute chest pain
If low probability of life-threatening illness: resolving symptoms, negative w/u
Typical angina
Retrosternal
Provoked by exertion
Relieved by rest/nitroglycerin
When to take a 15 lead EKG in MI
If hypotensive
If AV node involvement
If inferior MI
When is troponin sensitive for MI?
After 6-8 h
Westermark sign
Abrupt tapering of a vessel on chest film
Rate of normal CXR in PE
50%
Pericarditis pain relieved by
Sitting up and leaning forward
ECG in acute pericarditis
II,III,aVF,V4-V6: ST elevation, PR depression
aVR, V1: ST depression and PR elevation (reciprocal)
Sinus tachycardia
sBP in arms in aortic dissection
Difference > 20 mmHg
CXR in aortic dissection
Wide mediastinum
Left pleural effusion
Indistinct aortic knob
>4mm separation of intimal calcification from aortic shadow
Aortic dissection Tx
ABC
reduce BP and HR
Type A (ascending): urgent surgery
Type B (descending): medical
Urgent consult
Esophageal rupture symptoms
Sudden onset Severe pain After: endoscopy, forceful vomiting, labour, convulsion, corrosive injury, cancer Sepsis Subcutaneous emphysema
Imaging esophageal ruptur
CXR:
Pleural effusion
Pneumomediastinum
CT, water soluble contrast esophagogram
Tx of esophageal rupture
ABC early AB Thoracics consult NPO Consider chest tube
Abnormal skin sensation in herpes zoster precedes rash by
1-5 d
Reproduction of symptoms with movement or palpation is found in what percent of MI patients?
25% (similar to MSK)
Long QT syndrome
QT interval > 1/2 of cardiac cycle
ECG in dig toxicity
Gradual downward curve of ST
At risk for AV block, ventricular irritability
Abortive treatment for migrain
Fluids: 1 L bolus of NS
NSAID: ketorolac 30 mg IV
Antiemetic: prochlorprazine 10 mg IV, diphenhydramine 25 mg IV
Antiepileptic
Vasoactive medications
Dexa 10 mg IV
Halopridol, metoclopramide, ergotamine, sumatriptan…
Family doctor to consider prophylactic treatment
Tx of tension headache
Modify stressors
Local measures
NSAIDs
TCA
Migraine headache increases by
Activity
Tension or muscular headache aggravated by
Stress, sleep deprivation
SAH headache increases by
Exertion
Hyperattenuated signal around circle of willis on CT
SAH
If suspected SAH bu normal CT after 6 h of onset,
LP
Mx of SAH
Urgent neurosurgery consult
High-risk variables for SAH
Age 40 and higher Neck pain/stiffness Witnessed loss of consciousness Onset during exertion Thunderclap headache (instantly peaking pain) Limited neck flexion on examinatio
Eye exam in temporal arthritis
Relative afferent pupillary defect
Optic disc edema
Admission for headache
If: Underlying diagnosis is critical Underlying diagnosis is emergent Abnormal neurological findings Elderly Immunocompromised Pain is refractory to oral medications
Discharging headache
Most patients can be discharged
Assessed for risk of narcotic missuse
Instruct patient to return for fever, vomiting, neurology changes, or increasing pain
Morning Stiffness in inflammatory arthritis
> 30 min
Midday fatigue is in favor of which type of arthritis
Inflammatory
Investigation for arthritis
CBC, ESR, CRP, INR/PTT, blood cultures, urate
Joint x-ray +/- contralateral joint for comparison
Bedside U/S to identify effusion
Emergency vascular conditions needed to be ruled out in back pain
Aortic dissection AAA PE MI Retroperitoneal bleeding
Indications of imaging in back pain
Suspicion of emergencies, metastasis, high risk of fracture, infection, cancer or vascular causes
Use of dexamethasone for abortive treatment of migraine
26% reduction in headache recurrence within 72 hours
Red flags for back pain
Bowel or bladder dysfunction Anesthesia, saddle Constitutional symptoms Chronic disease Constant pain Paresthesia Age>50 and mild trauma IV drug use Neuromotor deficit
Status epilepticus
Continuous or intermittent seizure activity for greater than five minutes without regaining consciousness
immediate Mx of status epilepticus
Protect airway: positioning, ETT (if compromised or if increased ICP)
Monitor: V/S, ECG, oximetry, bedside BG
IV access
BDZ: IV lorazepam (0.1 mg/kg, max: 4 mg, 2mg/min) preferred over diazepam, repeat at 5 min if ineffective
Fluid
Thiamine 100 mg IM (adults), then
50% glucose, 50 mL
Blood sample: CBC, Lytes, Ca, Mg, BG, toxicology, AED levels, consider: B-hCG, PRL
Vasopressor if sBP<90, or MAP <70
Urgent management of status epilepticus
Second IV line
Foley
If status persists: phenytoin 20 mg/kg IV, an additional 10 mg/kg after 10 min
AED to prevent recurrence
EEG monitoring for non-convulsive status epilepticus
Mx of refractory status epilepticus
Consult ICU
Phenobarbital 20mg/kg IV, at 50 mg/min
Midazolam 0.2 mg/kg IV, then 0.05-0.5 mg/kg/h
Propofol
2-5 mg/kg IV then 2-10 mg/kg/h
Post-seizure Mx of status epilepticus
Investigate underlying: CT LP MRI ICP monitoringg
Minimum work up in an adult with first time seizure
CBC and diff
Electrolytes including Ca, Mg, PO4
Head CT
Control of seizures in adults without IV access
Midazolam 0.2 mg/kg up to 10 mg
When to discharge patients in status epilepticus
Patient returns to baseline function and is neurologically intact
Outpatient follow-up
Complete notification form for appropriate authorities regarding ability to drive
Warn regarding other safety concerns: no swimming, bathing children alone…
Anti-epileptic drug requiring cardiac monitoring
Phenytoin
Investigations for dyspnea
CBC, diff Lyte VBG Serial cardiac enzymes ECG WELL’s score CXR
Findings in favor of cardiogenic syncope
Sudden loss of consciousness with no warning or prodrome
Syncope accompanied by chest pain
Investigations for syncope
ECG Bedside BG CBC Lytes BUN/Cr ABG Troponin Ca Mg B-hCG D-dimertoxicology
Mx of syncope
ABC
IV
O2
Monitoring
If cardiogenic: admit
If low risk: discharge with F/U
Educate about avoiding orthostatic or situational syncope
Evaluate a patient for fitness to drive or work
If recurrent syncope, should avoid high-risk activities
General approach to sexual assault
ABC
Treat acute serious injuries
Ongoing emotional support
Obtain consent for: medical exam and treatment, evidence collection, disclosure to police
Sexual assault kit (if < 72h)
Label samples immediately and pass directly to police
Offer community crisis resources
Do not report unless pt requests or is <16 y
How long does the sperm remain motile in female genital?
6-12 h in vagina
5 d in cervix
Lab in sexual assault
VDRL, repeat in 3 mo if negative
Serum B-hCG
ABO group, Rh
Baseline serology (HIV, Hepatitis…)
Mx of sexual assault
Involve local/regional sexual assault team
Suture lacerations, tetanus prophylaxis
Gynecology consult if: foreign body, complex lacerations
Azithromycin 1 g (alt: doxy bid 7 d) + cefixime 800 mg PO x 1dose ( alt: ceftriaxone 250 IM)
+/- prophylaxis for hepatitis B and HIV
Pre and post counseling for HIV testing
Offer pregnancy prophylaxis: Plan B
Psychological support
Have the pt change and shower after exam
Disposition
Discharge if injuries/social situation permit
F/U with physician in rape crisis centre in 24 h
Best if pt does not leave ED alone
The most common STD after rape
Gonorrhea> chlamydia> syphilis > HIV
Suspicion about domestic violence
Suggestive injuries, often inconsistent with history provided
Somatic symptoms, chronic and vagie
Psychosocial symptoms
Clinical impression for example overbearing partner that won’t leave the patient’s side
Management of domestic violence
Treat injuries Document findings Ask about sexual assault Ask about children at home Encourage notification of police Safety plan Good follow up With family physician or social worker Be supportive and assess danger Patient must consent to follow-up investigation or reporting unless for children
Most common triggers for anaphylaxis
Foods, stings, drugs, radiographic contrast media, blood products, latex
Drugs causing anaphylaxis
Penicillin
NSAIDs
ACEI
Angioedema versus anaphylaxis
Angioedema does not tend to improve with standard anaphylaxis treatment
Management of moderate anaphylaxis
Epinephrine: 1:1000, 0.3-0.5 IM, lateral thigh q 5-15 min
Antihistamine: diphenhydramine, 25-50 mg IM
Salbutamol: 1cc via MDI
Symptomes: Generalized Urticaria, Angioedema, wheezing, tachycardia
Management of severe angioedema
ABC, may need ETT
Epinephrine: 1:1000, 0.1-0.3 mg, IV (or via ETT), repeat as needed
Antihistamines: diphenhydramine, 50 mg IV
Steroids: hydrocortisone 100 mg IV OR methylprednisolone 1mg/kg IV q 6h x 24 h
Large volume of crystalloid
Symptom: severe wheezing, laryngeal/pulmonary edema, shock
Second phase of anaphylaxis can happen within
Up to 48 hours
Disposition of anaphylaxis patient
Monitor for at least 4 to 6 hours in ED
Arrange follow-up with family physician in 24 to 48 hours
May need to be supervised
Educat patient on avoidance of allergens
Medications:
H1 antagonist, x3d
H2 antagonist, x3d
CS (prednisone 50 mg PO OD x 5d) to prevent secondary reaction
Investigations for asthma in ED
Peak flow meter
ABG: if severe respiratory distress
CXR: if Dx in doubt
Definition of hypotension
sBP > 30% decrease from baseline
Or
Adults: <90
11y and older: <90
1-10 yr: < 70+ 2 x age
1mo-1yr: < 70
Asthma pt with silent chest
Medical emergency
May require emergency intubation
Elements of well-controlled asthma
Daytime symptoms < 4x/wk
Nocturnal symptoms <1x/wk
No limitation in activity
No absence from work or school
Rescue inhaler use < 4x/wk
FEV1 > 90% personal best
PEF <10-15% diurnal variation
Mild infrequent exacerbations
Mild asthma symptoms and characteristics
FEV1 > 80%
Exertional SOB/cough + some nocturnal symptoms
Difficulty finishing sentences
Mild asthma management in ED
B-agonist
Monitor FEV1
Consider steroid (MDI or PO)
Moderate asthma symptoms and features in ED
FEV1: 50-80%
SOB at rest
Cough
Congestion
Chest tightness
Speaking in phrases
Inadequate relief from B-agonists
Moderate asthma management in ED
O2 to achieve O2 sat > 92%
SABA (ventolin): MDI or nebulizer q 5min
Short-acting anticholinergic (atrovent): MDI or nebs x3
Steroids: prednisone 40-60 mg PO
Severe asthma theaters in ED
FEV1 < 50%
O2 sat <90%
Agitated
Diaphoretic
Labored respirations
Speaking in words
No relief from B-agonist
Severe asthma management in ED
100% O2 to achieve O2 sat >90%
Anticipate need for intubation
Cardiac monitoring
IV access
SABA: nebulizer, 5 mg, continually
Short-acting anticholinergic: nebulizer, 0.5 mg x 3
IV steroids: methylprednisolone 125 mg
MgSO4 2g IV
Characteristics of asthma with imminent respiratory arrest
O2 sat <90%
Decreased HR
RR> 30
pCO2> 45
Exhausted Confused Diaphoretic Cyanotic Silent chest Ineffective respiratory effort
Management of asthma with Imminent respiratory arrest
100% O2 to achieve O2 sat >90%
Intubate (consider ketamine)
Cardiac monitoring
IV access
SABA: nebulizer, 5 mg, continually
Short-acting anticholinergic: nebulizer, 0.5 mg x 3
IV steroids: methylprednisolone 125 mg
Disposition of patient with exacerbated asthma
Discharge safe if:
FEV1 or PEF >60% predicted (may be safe if 40-60% predicted)
B-agonist MDI with aerochamber: 2-4 puffs q 2-4 h until symptoms are controlled. Then PRN
Inhaled CS aerochamber
Prednisone 30-60 mg/d x 7 d (if mod-sev)
Counsel on medication adherence
F/U with Primary care physician or asthma specialist
Risk factors for recurrence of exacerbation of asthma
Frequent ED visits Frequent hospitalizations Recent steroid use Recent exacerbation Poor medication compliance Prolonged use of high dose B-agonists
Tx of Mobitz II and 3rd degree block
ED:
Atropine with caution
Transcutaneous pacing
If failed, IV dopamine, epinephrine
Long-term:
Internal pacemaker
Tx of sinus bradycardia
Indication: if symptomatic
ED: atropine, transcutaneous pacing
Sick sinus node: transcutaneous pacing
Drug-induced: D/C or reduce offending drug, antidotes
Sinus tachycardia treatment
Treat underlying
BB if symptomatic
Supraventicular tachycardia with narrow QRS
Next step?
Is rhythm regular or irregular?
If SVT with regular rhythm?
Vagal maneuvers
Adenosine 6 mg IV -> 12 mg -> 12 mg
If rhythm converts: probable re-entry tachycardia (AVNRT»>AVRT)
Next step: monitor.
If recurred: adenosine, longer acting meds
If no rhythm conversion: atrial flutter, ectopic atrial tachycardia, junctional tachycardia
Next step: rate control, cardiology consult
If SVT with irregular rhythm
A Fib, atrial flutter, MAT
Next step: rate control (diltiazem, BB)
If pt with tachydysrrhythmia is unstable:
Immediate synchronized cardioversion
Most common
AF
Holiday heart
AF
Treatment principles in AF
Stroke prevention
Symptom control
Identification and treatment of underlying disease
How much does cardiac output decrease and AF?
20-30%
Treatment of AF
Unstable: immediate synchronized cardioversion
Onset> 48h or unknown:
Rate control
Anticoagulate for 3 weeks prior to and 4 weeks after cardioversion or TEE to R/O clot
Then: cardioversion
Onset <48h or already anticoagulated:
Cardiovert:
-electrical: synchronized DC
-chemical: procainamide, flecainide, propafenone
Long-term Mx:
Rate or rhythm control, consider anticoagulation (CHADS2 score)
VTach definition
3 or more consecutive ventricular beats at > 100 bpm
The most common cause of VTach
CAD with MI
Sustained VTach Tx
> 30 sec
Emergency
Hemodynamic compromise:
synchronized DC cardioversion
No hemodynamic compromise:
Synchronized DC cardioversion
Amiodarone
Procainamide
VFib Mx
Call code blue
ACLS
Torsades de pointes Tx
IV Mg
Isoprotrenol
Correct cause
Causes of torsades de pointes
Erythromycin TCA quinidine Quinolones Hypokalemia Hypomagnesimia
If WPW with AF
Amiodarone
Procainamide
Avoid AV blocking agents
COPD exacerbation cardinal symptoms
Increased dyspnea
Increased cough
Increased sputum
Purulence of sputum
Investigations in COPD
CBC Lytes ABG CXR ECG
NO PFT
Physical findings in COPD
Wheezing Laryngeal height 4 cm or less Forced expiratory time 6 sec or more Decreased breath sounds Decreased cardiac dullness
In COPD exacerbation R/O:
exacerbated CHF MI PE pneumonia Other infections Pneumothorax
COPD exacerbation Tx
O2 (keep O2 sat between 88-92%)
Bronchodilators:
SABA 4-8 puff with MDI q 15 min x 3
Short acting anticholinergic 4-8 puff with MDI q 15’ x 3
Steroid:
Prednisone 40-60 mg PO x 7-14 d
Or
Methylpred 125 mg IV bid-qid if severe/unable to take PO
AB:
TMP-SMX
Cephalosporins
Respiratory Q
Ventilation:
If, severe distress, signs of fatigue, hypercapnic, arterial pH < 7.35
CPAP, BiPAP
ICU:
If life-threatening, ICU admission for intubation and ventilation
Disposition of COPD
Low admission threshold if comorbidities
If discharge:
Taper steroid
Up to 4-6 puffs of ipratropium and salbutamol
F/U
Investigations for heart failure
CBC Lytes AST, ALT, Bil Cr, BUN Cardiac enzymes Brain natriuretic peptide CXR ECG ABG: if severe and refractory Echo: not usually used in ED R/O serious differentials
Mx of CHF
ABC
Sit upright
Cardiac monitoring
Continuous pulse oximetry
Saline lock IV
Foley
100% O2 by mask
May require BiPAP, ETT
Meds:
-diuretics: if volume overload:furosemide
- vasodilators: if sBP> 100: NTG SL q5 min, Nitrodur patch. If no response/signs of ischemia NTG IV. If severe/refractory HTN: nitroprusside
- ionotropes/vasopressors: if sBP < 90. With shock: dopamine, without shock: dobutamine
- treat precipitating factors
- cardiology or medicine consult
CHF on CXR
Pulmonary vascular redistribution
Perihilar infiltrates
Interstitial edema, Kerley B lines
Alveolar edema, bilateral infiltrates
May: cardiomegaly, pleural effusion
Peribronchial cuffing
Fissural thickening (fluid in fissure)
Hospital Mx of CHF required if:
Acute MI
Pulmonary edema or severe respiratory distress
Severe complicating medical illness such as pneumonia
Anasarca
Symptomatic hypotension or syncope
Refractory to outpatient therapy
Thromboembolic complications requiring intervention
Clinically significant dysrhythmia
Inadequate social support for safe outpatient management
Persistent hypoxia requiring supplemental oxygen
Well,s Criteria for DVT
Active cancer 1
Paralysis, paresis, recent immobilization of leg 1
Recently bedridden x3d or major surgery within 4 weeks 1
Local tenderness 1
Entire leg swollen 1
Calf swelling 3 cm> asymptomatic leg 1
Unilateral pitting edema 1
Collateral superficial veins 1
Alternative Dx more likely -2
Well’s criteria for DVT scoring
0: low probability
1-2: moderate probability
3 and higher: high probability
The first step in suspicion for DVT
Compression U/S
Mx of DVT
LMWH
Warfarin started at same time
LMWH D/C when INR 2-3 for 2 consecutive days
- can use DOAC (rivaroxaban, apixaban) in acute Mx of symptomatic DVT
- thrombolysis if: extensive DVT and limb compromise
- IVC filter if: anticoagulation is contraindicated
Duration of anticoagulation therapy
If transient coagulopathy: 3 mo
If unprovoked coagulopathy: 6 mo
If ongoing coagulopathy: life-long
Well’s criteria for PE
Previous history of DVT/PE 1.5
HR> 100 1.5
Recent immobility or surgery 1.5
Clinical signs of DVT 3
Alternative diagnosis less likely than PE 3
Hemoptysis 1
Cancer 1
Interpretation of Well’s criteria for PE
<2 low probability
2-6: intermediate probability
> 6: High probability
ECG in PE
S1Q3T3
Sinus tachycardia
T wave inversion in anterior and inferior leads
If PE suspicion, next step?
PERC score: Age > 50yr HR > 100 O2 sat <94% Prior Hx DVT/PE Recent trauma/surgery Hemoptysis Exogenous estrogen Clinical signs suggesting DVT
PERC interpretation
0/8: PE excluded
1-8/8: proceed to Well’s
How to proceed according well’s score in PE
If low probability:
Check D-dimer
- if < 500, PE excluded
-if > 500, CT pulmonary angiogram
If moderate-high probability: CT-PA
- if negative: PE excluded
- if positive: PE confirmed
V/Q scan if CT-PA unavailable or contraindicated
PE in pregnancy
Use PERC with caution
V/Q scan instead of CT-PA
Mx of PE
The same as DVT
Thrombolysis if: extensive PE causing hemodynamic compromise/cardiogenic shock
-catheter-directed thrombolysis or surgical thrombectomy if contraindication to thrombolysis
Often can be treated as outpatien
Analgesia for chest pain
Referral to medicine for coagulopathy and malignancy w/u
When to admit PE pt?
Hemodynamically unstable Require supplemental O2 Major comorbidities Lack of sufficient social support Unable to ambulate Need invasive therapy
Respiration in DKA
Kussmaul
Investigations fo DKA
CBC, electrolytes, Ca, Mg, PO4, BUN, Cr, glucose, ketones, osmolality, AST/ALT/ALP, amylase, troponin
Urine glucose and ketones
ABG or VBG
ECG
Mx of DKA
Rehydration:
Bolus of NS, then high rate NS
K:
KCl
(20 mEq/L if adequate renal function and initial K < 5.5)
Cardiac monitoring if K: Nl or low
Insuline: Not if K < 3.3 Initial bolus of 5-10 unit, regular, IV Then continuous infusion at 5-10/h Once glucose < 14, subcutaneous injection, D/C IV Once glucose <15, add D5W to IV fluids
Bicarbonate: if pH < 7
How to correct pseudohyponatremia
Add 3 Na per 10 glucose over 5.5
Triad of DKA
Hyperglycemia
Ketosis
Acidosis
Also: ketonuria
Investigations for HHS
CBC Lytes, Ca, Mg, PO4 BUN, Cr Blood glucose Ketones Osmolality Urine: glucose and ketones ABG/VBG Investigations for underlying causes: CXR, ECG, blood/urine C/S
Mx of HHS
Rehydration IV NS (Total deficit: 100 cc/kg body weight) O2 Cardiac monitoring Insuline (controversial) Treat underlying ( Ischemia, Infarction, Infection, Insulin missed, Intoxication)
Mx of hypoglycemia
IV access
Rapid blood glucose measurement
D50W 50 mL IV push
PO glucose if mental status permits
If IV access not possible, glucagon 1-2 mg IM, repeat once in 10-20 min
O2 monitoring
Cardiac monitoring
Frequent blood glucose monitoring
Thiamine 100 IM
Full meal ASAP
Watch for prolonged hypoglycemia due to long-acting insulins or sulfunylurea
Search for cause (insulin, alcohol, OHA)
The most common reason for hypoglycemia
Excessive insulin use in setting of poor PO intake
Levels of Na causing seizures and coma
> 158
Tx of hypernatremia
Salt restrict
Give free water
No more correction than 12 /24 h
Hyponatremia Mx
Water restrict/NPO
Seizure/coma: 100cc 3% NaCl
If hypovolemia: ringer lactate
If hypervolumia: furosemide
Limit total rise to 8/ 24h
Mx of hyperkalemia
Protect heart: Ca gluconate
Shift K into cells:
D50W+ insulin
NaHCO3
Salbutamol
Remove K:
Fluid+ furosemide
Dialysis
Hypokalemia Mx
K-Dur
K sparing diuretics
IV solutions with 20-40 mEq/L KCl over 3-4 h
May need to restor Mg
Hypercalcemia Mx
Isotonic saline (usually dehydrated) \+ furosemide if hypervolemic Bisphosphonate Dialysis Chelation (EDTA, oral PO4)
Hypocalcemia Mx
If acute ( ionized Ca < 0.7): immediate treatment: IV calcium gluconate
EOD in hypertensive crisis
CNS:
Stroke/TIA, headache, altered mental status, seizures, hemorrhage
Retinal:
Visual changes, hemorrhage, exudates, papilledema
Renal:
Nocturia, elevated Cr, proteinuria, hematuria, oliguria
Cardiovascular:
Ischemia/angina, infarction, dissection (back pain), CHF
Gastrointestinal:
N/V, abdominal pain, elevated liver enzymes
Investigations in hypertension crisis
CBC, Lytes, BUN, Cr
U/A
PBS
CXR (if SOB, back pain)
ECG, troponin, CK (if chest pain)
CT head (if neurological findings or severe headache)
Toxicology screen (if sympathomineric overdose suspected)
Management of hypertensive crisis (emergency)
Aim: Lower BP gradually and progressively in 24 to 48 hours
Lower BP by 25% during first 60 minutes.
Nitroprusside
Labetalol
Establish arterial line
Transfer to ICU for further reduction
Management of hypertension crisis in Ischemic stroke
maintain BP> 150/100 for 5 d
In case of aortic dissection and hypertension crisis
Rapid reduce of BP to 110-120 STAT
Do not resuscitate with IV fluid
In case of excessive catecholamines in hypertension crisis
Do not use BB (except labetalol)
In case of ACS and hypertension crisis
First address ischemia, then BP
Hypertensive urgency
Severely elevated BP > 180/110
No evidence of EOD
The most common reason for hypertension urgency
Not adherence with medications
Tx of HTN urgency
Goal: differentiate hypertension urgency from emergency
Initiate/adjust antihypertensive therapy
Monitor in ED (up to 6 h)
Discharge with F/U for 48-72 h
1st line treatment in HTN crisis
Sodium Nitroprusside
Na nitroprusside adverse effects
N/V, muscle twitching, sweating, cyanide intoxication, coronary steal syndrome
Caution with nitroprusside
High ICP
Azotemia
Caution with nicardipine
Acute CHF
Special hypertensive indication for NTG
MI/pulmonary edema
Caution in fenoldopam
Glaucoma
HTN with catecholamine excess
Phentolamine
Investigations for ACS
ECG STAT
Troponin (2-6 h after onset)
CXR to R/O other causes
Mx of ACS
Stabilize:
ABC, O2, IV access, cardiac monitoring, oximetry
ASA 162-325 chewed
NTG 0.3 SL q5min x 3 (IV if persistent pain, CHF, HTN)
Anticoagulation (UH, LMWH, fondaparinux)
Early cardiology consult for reperfusion therapy
Atorvastatin 80 mg (to stabilize plaque)
BB (if no sign of CHF, hemodynamic compromise, bradycardia, severe reactive airway disease)
ACEI (within 24h)
NTG contraindications
Hypotension
PDE-inhibitor use
Right ventricular infarction (1/3 of inferior MIs)
Reperfusion strategy
UA/NSTEMI:
Early coronary angiography recommended if high TIMI score
STEMI:
Preferred: primary PCI (within 90 min)
If unavailable within 120 min of medical contact, symptoms <12 h and no contra: thrombolysis
Sepsis definition
Life-threatening organ dysfunction (by a dysregulated host response to infection)
A change in baseline SOFA score equal or higher than 2
Septic shock definition
Profound circulatory, cellular, metabolic abnormalities.
Require vasopressors to maintain MAP 65 or higher
Serum lactate 2 or higher without hypovolemia
Mx of septic shock
ABC Monitors Lines Aggressive fluid Ventilatory/inotropic support Cultures Early empiric ABs- broad spectrum and atypical coverage Source control Monitor adequate resuscitation: V/S, serial lactate, IVC on U/S
TIA duration
<24 h
Typically <1h
VBA stroke
Loss of pain and temprature in ipsilateral face and contralateral body
Cranial nerves palsy
Cerebellar/brainstem deficits: vertigo, nystagmus, diplopia, visual field deficit, dysphasia, facial hyposthesia, syncope, ataxia
ACA stroke
Contralateral hemianesthesia and hemiparesis (legs > arms/face)
Gait apraxia, altered mental status, impaired judgement
MCA stroke
Contralateral hemianesthesia and hemiparesis (arms/face > legs)
Contralateral homonymous hemianopsia,
Ipsilateral gaze
PCA stroke
Contralateral homonymous hemianopsia
Cortical blindness
Impaired memory
Investigations for stroke
CBC Lytes BG Coagulation studies \+/- cardiac biomarkers \+/- toxicology screen Non-contrast CT head ECG \+/- echo \+/- carotid doppler, CTA, MRA
Mx of stroke
ABC
Intubate if GCS<9, rapidly decreasing GCS, inadequate airway protection reflexes
Thrombolysis (<4.5 h)
elevate head of bed (if risk of elevated ICP, aspiration, worsening cardiopulmonary status)
NPO
IV
+/- cardiac monitoring
Fluid: careful judging
BP control
Glycemic control (keep fasting glucose <6.5 in first 5 d)
Cerebral edema control: hyperventilation, mannitol
Consult: neurosurgery, neurology, medicine
Requirements for thrombolysis
Need acute onset <4.5 h from drug administration time Compatible physical findings Normal CT with no bleed >60 min without improvement
Indications of BP control in stroke
If severe HTN > 200/120 or MAP >140
HTN associated with hemorrhagic stroke transformation
Cardiac ischemia
Aortic dissection
Renal damage
Use: IV nitroprusside or labetalol
U/S for Dx of DVT
High sensitivity and specificity for proximal clot
Lower sensitivity for calf DVT
If positive: treat DVT
If negative and low-risk: rule out DVT
If negative and moderate-high risk: repeat in 5-7 d
If inconclusive/inadequate: Venography or MRI
D-dimer value in DVT
Only useful at ruling out DVT if it’s negative and low-moderate risk patients
False positive D-dimer in:
Elderly Infection Recent surgery Trauma Hemorrhage Late in pregnancy Liver disease Cancer
Medications in TIA/Stroke
Thrombolysis
Antiplatelet agents: to prevent recurrent stroke or stroke after TIA:
1st line: ASA
2nd line: clopidogrel, aggrenox
Anticoagulation: if immobile or AFib
F/U: endarterectomy, cardiovascular risk optimization
4 types of dizziness
Vertigo (spinning)
Lightheadedness (disconnect from environment)
Presyncope (almost blacking out)
Dysequilibrium (unstable, off-balance)
Indications of CT head in earache
Mastoiditis
Malignant otitis externa
Sudden SNHL
Emergency
High dose steroid
Urgent referal
Unilateral tinnitus in elderly
Acoustic neuroma until proven otherwise
Absolute contra to thrombolytics
Suspected SAH Previous ICH Cerebral infarct/severe head trauma within the past 3 month Recent LP Recent arterial puncture at non-compressible site Brain tumor Metastatic cancer BP > 185/110 Bleeding diathesis PTT> 15s or INR >1.7 Plt <100,000 BG <2.8 or >22 ICH on CT Large volume infarct Previously ADL dependent Seizures at onset causing postictal impairment
Relative contra to thrombbolysis
Minor symptoms
Rapidly improving
Very severe symptoms/ coma
Major surgery within past 14 days
GI or urinary hemorrhage within the past 21 d
The most common reason for epistaxis
Trauma
Inv for epistaxis
CBC
PT/PTT
X-ray, CT as needed
Tx of epistaxis
Aim: localize bleeding and achieving hemostasis
ABC
Clear clots (blowing nose, suction)
Lean forward!
Pinch cartilaginous portion for 20 min, twice
Assess blood loss: vitals, IV NS, crossmatch 2 units of pRBC
If fail twice, proceed to packing
Prophylactic AB if packing both nares
If controlled with anterior pressure: cautery with silver nitrate if the site identified (one side only)
If suspected posterior bleeding or anterior packing does not provide hemostasis: consult ENT for posterior packing
Posterior packing issues
Requires monitoring
Can you cause significant vagal response
Can lead to significant blood loss
Usually requires admission
Packing procedure
Clear nose
Topical anesthesia/vasoconstrictors
Insert vaseline gauze pack/ nasal tampon/ nasal balloons
Resorbable pack for thrombocytopenia
If bleeding stops: arrange F/U in 48-72 h: reassess, remove pack
If packing does not provide hemostasis: ENT consult
Disposition of epistaxis
Discharge upon stabilization
Appropriate F/U
Educate pt: Humidifiers Saline spray Topical ointment Avoiding irritants Control HTN
Complications of nasal packing
Hypoxemia
TSS
Aspiration
Pharyngeal fibrosis/stenosis
Alar/septal necrosis
The most common cause of bleeding during first and second trimesters of pregnancy
Friable cervix
Inv in vaginal bleeding
B-hCG CBC PTT/INR Blood type and Rh Type and cross if significant blood loss Transvaginal U/S Abdominal U/S
Mx of vaginal bleeding
ABC
if unstable: cardiac monitoring, oximetry
If pregnant and Rh - : Rhogam
If 1st/2nd T:
If EP: surgery/MTX
If intrauterine pregnancy: F/U with OB/GYNG
If U/S indeterminate: further W/U with OB
Complete abortion: discharge if stable
All other abortions: consult GYN
If 2nd/3rd T: consult
Postparum: ABC, 2large bore IVs, rapid infusion, type and cross 4 units of blood, consult
If non-pregnant:
Unstable: admit to gyn: IV hormonal therapy, possible D&C
If stable non-structural: tranexamic acid, Provera x 10d
If stable structural: outpatient gynecology referral
Vaginal bleeding in IVF
EP cannot be ruled out by intrauterine pregnancy by bedside U/S
The most common type of nephrolithiasis
Calcium oxalate 80%
Inv for nephrolithiasis
CBC
Lytes
BUN, Cr
U/A:R&M, C&S
Non-contrast spiral CT (choice)
Abdominal U/S (if childbearing age)
AXR: initial investigation in pts who have a Hx of radioopaque stone and similar episodes, perform CT if negative AXR
Stone analysis
Stones found on AXR
Calcium, struvite, cystine
Stones missed on AXR: small, uric acid, overlying bones
Mx of nephrolithiasis
Ketorolac
Antiemetics
IV fluids
a-blocker in selected cases
Urology consult if stone>5 mm, obstruction, infection
Disposition of nephrolithiasis pt
Most can be discharged:
Stable
Adequate analgesia
Able to tolerate oral meds
Advise: Hydration Limit protein Limit Na Limit oxalate Limit alcohol
Admission of nephrolithiasis if:
Intractable pain Fever Evidence of pyelonephritis Single kidney with your ureteral obstruction Bilateral obstructing stones Intractable vomiting Compromised renal function
If high velocity injury to eye suspected
X-ray Or U/S Or CT
To exclude presence of inteaocular metallic foreign body
Mx of ophthalmologic foreign body
Copious irrigation with saline
Remove foreign body under slit lamp exam with cotton swab or sterile needle
Antibiotic drops qid until healed
No patching, especially for contact lens wearers
Tetanus prophylaxis
Ophthalmology consult if glob penetration suspected
Topical anesthetics only for examination
Contraindications to pupil dilation
Shallow anterior chamber
Iris-supported lens implant
Potential neurological abnormalities requiring pupillary evaluation
Caution with Cardiovascular disease as mydriatics can cause tachycardia
Inv for rash presenting to ED
CBC
Lytes
Cr
AST, ALT, ALP, B/C, skin biopsy, serum Ig levels (IgE)
Mx of skinlesions
Judicious IV fluid
Lyte control
Vasopressors
Prevention of infection
DDx of fixed pupils with red eye
Acute angle glucoma
Iritis
Acute angle closure glaucoma Tx
Consult
Topical:
BB
Adrenergics
Cholinergics
Systemic:
Carbonic anhydrase inhibitors
Hyperosmotic agents
Chemical burn of eyes
Irrigate at site of accident IV NS drip in ED with eyelid retracted Swab fornices Cycloplegic drops Topical AB Patching
Orbital cellulitis treatment
Admission Ophthalmology consult Blood culture Orbital CT IV antibiotics (ceftriaxone+vanco) Drainage of abscess
Treatment of retinal artery occlusion
Restore blood flow <2h Massage globe Decrease IOP: -topical BB -inhaled O2/CO2 mix -IV Diamox (acetazolamide) -IV mannitol -drain aqueous fluid
Retinal detachment treatment
Consults for scleral buckle/pneumatic retinoplexy
Loss of red reflex
Retinal detachment
Heat exhaustion
Loss of circulatory volume
Water depletion: if fluid not adequately replaced
Salt depletion: if fluid replaced with hypotonic fluid
Malaise, headache, fatigue, T <40.5 (usually normal)
Dehydration (HR, orthostatic hypotension)
Tx: rest, cool environment, IV NS if orthostatic hypotension, otherwise slow oral replacement of fluid loss
Heat stroke
Failure of compensatory heat shedding mechanisms
Subtypes: classical, exertional
Classical:
high ambient temperatures
Often older, poor, sedentary, immobile
Dry, hot skin, temp > 40.5, altered mental status, seizures, delirium, coma. May have elevated AST,ALT
Exertional:
High endogenous heat production that overwhelms homeostatic mechanisms.
Often: younger, active
Diaphoretic, hot skin, temp > 40.5, altered mental status, seizures, delirium, coma. May have DIC, ARF, rhabdomyolysis, marked lactic acidosis
Tx of heat stroke
Cool body temperature
Monitor temp closely
Secure airway (risk of seizures/aspiration)
Fluid resuscitation if still hypotensive
Avoid B-agonists/peripheral vasoconstriction/antipyretics
If no response to Tx, DDx: meningitis, thyroid storm, delirium tremens, anticholinergic poisoning, other infections
Complications of hypothermia
Coagulopathy Acidosis Ventricular dysrhythmia Asystole Volume and electrolyte depletion
Inv in hypothermia
CBC Lytes, Mg, Ca Glucose BUN/Cr Coagulation profile Amylase CXR ECG Rectal thermometer Foley NG Monitor metabolic status frequently
Symptoms of hypothermia
Mild (32-34.9):
Tachycardia, tachypnea, shivering
Ataxia, dysarthria
Moderate (28-31.9):
Dysrhythmia, asborne (J) wave,
Loss of shivering, muscle rigidity
Decreased LOC, Combative behavior, dilated pupils
Severe (<28):
Hypotension, apnea, VFib, asystole
Acidemia, flaccidity
Coma
Tx of hypothermia
Gentle fluid and electrolyte replacement
Passive external rewarming:
If stable and T> 32.2
Insulating blanket
Active external rewarming:
Heating blanket
Possibility of after-drop. Safe if in conjunction with core rewarming
Active core rewarming:
(Pts with T<32.2 or cardiovascular instability)
Warn humidified oxygen
Warm IV fluids
Peritoneal dialysis with warm fluids
Gastric/colonic/pleural irrigation with warm fluids
Passive external warming only suitable for T:
> 32.2
Approach to VFib due to hypothermia
Do all procedures gently
Check pulse for 1 min
DO NOT CPR if any pulse at all
If in VFib: defibrilate up to 3 times if coreT<30)
Intubate if needed
Ventilate with warm humidified O2
Meds: vasopressors/antidysrhythmic: may try one dose
Focus of treatment: rewarming
Frostbite classification
First degree:
Paresthesia, pruritus
Erythema, edema, hyperemia
Second degree:
Numbness
Clear blisters, erythema, edema
Third degree:
Pain, burning, painless if severe, throbbing on thawing
Hemorrhagic blisters, skin necrosis, edema, no movement
Fourth degree:
Extension into subcuticular, osseous, muscle tissue
Mx of frostbite
Treat hypothermia:
O2, IV fluids, body rewarming
Remove wet and constrictive clothing
Immerse in 40-42° C agitated water for 10-30 min
(Needs adequate analgesia)
Clean injured area and leave it open to air
Aspiration/debridement of blisters (contraversial)
Debride skin
Tetanus prophylaxis
Consider penicillin G (high risk of infection)
Surgical intervention to release restrictive eschars
Never allow a thawed area re-chill
Burn classification
1st degree:
Only epiderm
2nd degree: Superficial partial thickness: Blister, very painful Deep partial thickness: Hair follicles, sebaceous glands, blister, white-yellow exposed dermis, absent sensation
3rd degree:
Epiderm and all dermal layers:
Pale, insensate, charred, leathery
4th degree:
Fat, muscle, bone
Mx of burns
Remove noxious agent, stop burning process
Airway (esp if >40% or smoke inhalation)
2 large bore IVs
Resuscitate for 2nd and 3rd degree burns:
Parkland: Ringer’s lactate: 4x wt x % of burnt area (excluding 1st degree burn). Half in first 8h, half in next 16 h.
+ maintenance if no oral tolerance
Pain relief: continuous morphine with breakthrough bolus
Investigations, wound care, escharotomy/fasciotomy for circumferential burns
Topical AB
Tetanus prophylaxis
Best measure of resuscitation is:
Urine output:
40-50 cc/h (0.5 cc/kg/h)
Avoid diuretics
Burn wound care
Prevent infection Clean/debride with mild soap and water Sterile dressing Topical AB Tetanus prophylaxis (if deeper than superficial dermis)
Disposition of burn patient
Admit if: 2nd degree > 10% BSA Any significant 3rd degree burn Electrical burn Chemical burn Inhalation injury Underlying medical problems ImSup
Direct thermal injury in inhalation injury
Limited to upper airway, above vical cords
Investigations in burn
CBC Lytes U/A CXR ECG ABG Carboxyhemoglobin
Investigations for inhalation injury
Hb-CO Co-oximetry ABG CXR \+/- bronchoscopy
If high pO2 but low O2 sat
CO poisoning
Mx of CO poisoning
100% O2
+/- hyperbaric O2
Mx of direct thermal injury to upper airways
Humidified O2 Early intubation Pulmonary toilet Bronchodilators Mucolytics: NAC
What type of bite has hepatitis B or HIV risk?
Human bite
Bite investigations
If bony injury/infection suspected:
X-ray to check for fx and gas in tissue
If child with scalp bite wound:
Skull film +/- CT to R/O skull perforation
If radiolucent foreign body suspected: U/S
If abscess suspected: U/S
Mx of bite
Wound cleansing:
Copious irrigation
Puncture wounds: irrigate/debride if feasible but not if sealed or very small opening.
Don’t hydrodissect
Debride:
Esp in crush injuries
Culture wounds:
If signs of infection
Anaerobic culture if: foul smelling, necrotizing, abscess
Suturing:
For face and scalp (vascular)
Secondary intention healing for hand, foot, pretinial
AB prophylaxis
Tetanus prophylaxis
AB for bite
3-5 d
For all bite wounds to the hands.
For other high-risk bites.
Cat»>Dog bites:
Amoxicillin-clavulanate
Human bite:
Amoxicillin-clavulanic acid
Rabies:
Post exposure vaccine and Ig
Insect bite Mx
ABC
If shock: epinephrine
Antihistamines
Cimetidine 300 mg, IV/IM/PO
Steroids
If SOB/wheezing: B-agonists nebulizer
When to admit pt with bite injury?
Mod-sev infection Infection in ImCompr Not responding to oral AB Penetrating injuries to tendons, joints, CNS Open fx
Complications of near drowning experience
Volume shifts Electrolyte abnormalities Hemolysis Rhabdomyolysis Renal DIC
Investigations for near drowning
CBC Lytes ABG BUN,Cr INR, PTT U/A (drug screen, myoglobin) CXR C-spine imaging ECG
Mx of near drowning
ABC (trauma, hypothermia, shock): always initiate CPR in drowning-induced cardiac arrest, even if hypothermic. Ckntinue until fully rewarmed
Cardiac and O2 monitors
Intensive respiratory care:
Ventilator (if pO2 <60, pCO2>50, decreased respiration)
+/- ETT
Hugh flow O2/CPAP/BiPAP
Dysrhythmias (usually respond to correction of hypoxemia, acidemia, hypothermia)
Vomiting: NG
Convulsion: O2 (if no response, diazepam)
Bronchospasm: bronchodilators
Prophylactic AB if: contaminated water, hot tub
Disposition of drowning pt
If non-significant submersion:
discharge after short observation
If significant submersion: Long period (24h) of observation, even if asymptomatic (pulmonary edema can appear late)
If CNS symptoms/hypoxemia:
Admit
If severe hypoxemia, decreased LOC: ICU
Anticipate secondary drowning
ABCD3EFG of toxicology
Airway Breathing Circulation Drugs (ACLS, universal antidotes) Draw blood Decontamination (decrease absorption) Expose/Examine Full vitals, ECG monitor, Foley, X-rays Give specific antidotes/ Tx
Universal antidotes
O2:
If hypoxic
Exceptio: paraquat, diquat
Naloxone
Dextrose:
To any pt with altered LOC
Measure BG first
Thiamine (must give before dextrose):
All pts
100 mg IV/IM
Necessary for glucose metabolism
Blood tests in intoxication
CBC Lytes BUN/Cr BG INR/PTT Osmolality ABG, O2 sat ASA, acetaminophen, EtOH \+/- Drug levels Ca, Mg, PO4 Protein, Alb, lactate, ketones, liver enzymes, CK
AG formula and normal amount
Na - (HCO3 + Cl)
Normal: 12 or less
Radioopaque pills or objects
Calcium Chloral hydrate CCl4 Heavy metals Iron Potassium Enteric coated salicylate Some foreign bodies
Electrolyte abnormality caused by digitalis glycosides
Hyperkalemia
Electrolyte abnormality caused by fluoride
Hyperkalemia
Electrolyte abnormality caused by theophylline
Hypokalemia
Electrolyte abnormality caused by BB
Hyperkalemia
Electrolyte abnormality caused by B-adrenergic agents
Hypokalemia
Electrolyte abnormality caused by caffeine
Hypokalemia
Electrolyte abnormalities caused by soluble barium salts
Hypokalemia
The effects of ASA on blood glucose
Hypoglycemia
The effects of ethanol on blood glucose
Hypoglycemia
The affect of salicylates on ventilation
Hyperventilation
The effect of TCA on QRS complex
Wide QRS
The effect of Quinidine on QRS
Wide QRS
The effect of class Ia and Ic antiarhythmics on QRS
Wide QRS
The effect of antipsychotics on ECG
Prolonged QT interval
Contraindications to charcoal
Caustics
Small bowel obstruction
Perforation
Dosage of charcoal
10 g/g drug ingested
Or
1 g/kg
Whole bowel irrigation indications
Polyethylene glycol
By mouth
Indications: Awake, alert, can be nursed upright OR Intubated Delayed release product Drug/toxin not bound to charcoal Drug packages Recent toxin ingestion
Contraindications to bowel irrigation
Evedence of ileus
Perforation
Obstruction
Indications for surgical removal in intoxication
Drugs that are toxic
Drugs that form concretions
Drugs that cannot be removed by conventional means
Evidence of drug packages breakage
Indications for urine alkalinization
ASA
MTX
Phenobarbital
Chlorpropamide
Urine pH >7.5
Indications for multidoes activated charcoal
Carbamazepine Phenobarbital Quinine Theophylline Toxins which undergo enterohepatic recirculation
Indications for hemodialysis in intoxication
Toxins that have:
High water solubility, Low protein binding, Low molecular weight, adequate concentration gradient, small volume of distribution, rapid plasma equilibration
Removal of toxins will lead to clinical improvement
Advantage is shown over other modes of therapy
Predicted that drug or metabolite will have toxic effects
Impairment of normal routes of elimination
Clinical deterioration despite maximal medical support
Substances for which hemodialysis is useful
Methanol Ethylene glycol Salicylate Lithium Phenobarbital Chloral hydrate Theophylline Carbamazepine Valproate MTX
Anticholinergic overdose signs and symptoms
Hyperthermia Dilated pupils Dry skin Vasodilation Agitation/hallucination Ileus Urinary retention Tachycardia
Cholinergic toxicity signs and symptoms
Diaphoresis Diarrhea Decreased BP Urination Miodis Bronchospasm Bronchorrhea Bradycardia Emesis Excitation of skeletal muscle Lacrimation Salivation Seizures
Extrapyramidal toxidrome signs and symptoms
Dysphonia Dysphagia Rigidity Tremor Motor restlessness Akathisia (crawling sensation) Dyskinesia (constant movements) Dystonia
Hb deranging toxidromes signs and symptoms
Increased respiratory rate Decreased LOC Seizures Cyanosis unresponsive to O2 Lactic acidosis
Intoxication with opioids, sedatives, hypnotics, EtOH signs and symptoms
Hypothermia Hypotension Respiratory depression Dilated or constricted pupils CNS depression
Medications causing serotonin syndrome
MAOI TCA SSRI opiate analgesics Cough medicine Wt reduction medications
Examples of cholinergics
Mushrooms Trumpet flower Physostigmine Organophosphates Carbamates Nerve gas
Examples of anticholinergics
TCA (antidepressants) Carbamazepine Diphenhydramine (antihistamines) Antiparkinsonism Antipsychotics Antispasmodics Belladona (atropine)
Urine alkalization method for ASA treatment
Fluid resuscitate first
3 amps of NaHCO3/L of D5W at 1.5 x maintenance
Add 20-40 mEq/L KCL if pt is able to urinate
Protocol for warfarin overdose
INR < 5:
Cessation of warfarin, observation, serial INR/PT
5.1 -9.0:
If no RF for bleeding, hold 1-2 d, reduce dose
If increased risk of bleeding, VitK 1-2 mg PO
9.1-20.0:
Hold, vitK 2-4 mg PO, serial INT, aditional vitK if necessary
> 20:
Hold, vit K 10 mg IV over 10 min. Increase dosing q4h if needed
Any INR with life-threatening bleeding or surgical plan within 6h: PCC
Tx of acetaminophen overdose
Activated charcoal
NAC
Tx of acute dystonic reaction
Benztropine
Diphenhydramine
Tx of anticholinergic intoxication
Charcoal
Supportive
Tx of ASA intoxication
Charcoal
Urine alkalinization
Hemodialysis if: intractable metabolic acidosis, very high levels, EOD
Tx of BDZ intoxication
Charcoal
Flumazenil
Supportive
Tx of BB overdose
Charcoal
High dose insuline euglycemic therapy
Dialysis
Intralipids
Tx of CCB intoxication
Charcoal CaCl2 High dose insulin euglycemic therapy Inotropes Intralipids
Tx of cocaine intoxication
Charcoal if oral
Supportive
Intralipid if life-threatening
BB CONTRAINDICATED
CO poisoning
Supportive
100% O2
Tx of cyanide intoxication
Hydroxycobalamin
Tx of dig toxicity
Charcoal
Digoxin-specific Ab fragments
Tx of ethanol toxicity
Thiamin 100
Check glucose esp in children
Tx of intoxication with methanol or ethylen glycol
Fomepizole or Ethanol 10% Urgent hemodialysis required Folic acid for methanol B1 and B6 for ethylene glycol
Tx of heparin toxicity
Prothamine sulfate
Tx of MDMA intoxication
Charcoal
Supportive
Tx of TCA intoxication
Charcoal Supportive NaHCO3 if wide QRS/seizures intralipid FLUMAZENIL CONTRAINDICATED
Correlation of alcohol levels and symptoms
Poor
Effect of alcohol on blood pressure
Hypotension if acute consumption
HTN if chronic
Tx of alcohol withdrawal
Diazepam/Lorazepam
Thiamine
MgSO4 (if hypomagnesemic)
Admit if: DT or multiple seizures
Common deficiencies with alcohol
Thiamine B1 Niacin B3 Folate Glycogen Mg K Hypophosphatemia Hypocalcemia
Alcoholic ketoacidosis
AG metabolic acidosis Urine ketones Low glucose Normal osmolality Hx of chronic alcohol intake with abrupt decrease/cessation Malnourished Abdominal pain N/V
Tx Dextrose Thiamine prior to dextrose Volume repletion Resolves in 12-24 h
Methanol, ethylene glycol acid-base derangement
AG metabolic acidosis with osmolar gap
AST/ALT ratio suggestive of alcohol misuse
> 2
Also increased GGT with acute ingestion
Disposition of alcohol withdrawal pt
Discharge when: Stable V/S Walk unassisted Oriented Can obtain medications Can F/U
Offer social services
Disposition of TCA intoxication
If prolonged/delayed cardiotoxicity: ICU
If asymptomatic and no clinical signs:
Proper decontamination + normal ECG + 6h observation, then discharge
If sinus tachycardia alone: observe in ED
most common finding in TCA toxicity: sinus tachycardia
ASA/Acetaminophen toxicity disposition
If borderline levels, check again in 2-4 h after first level
For ASA: discharge if at least 2 downward levels (3 levels minimum)
Oral hypoglycemics intoxication disposition
Admit all hypoglycemics for at least 24 h and 12 h if last octreotide dose
If asymptomatic, observe for at least 8 h
octreotide is considered for glyburide
Mx of acute psychosis
Violence prevention: Remain calm, empathic, reassuring Ensure safety of staff and pts Have extra staff/ security on hand \+/- physical restraint, chemical tranquilizer
BDZ: lorazepam
Antipsychotics: olanzapine, halopridol
Treat underlying medical condition
Psychiatry consult
Mx of suicidal pt
Ensure pt safety
Assess thoughts, means, action, previous attempt
Admit if: Evidence of active intent Organized plan Access to lethal means Psychiatric disorder Intoxication
Do not start long-term meds in ED
Psychiatry consult
Infant < 1 yr with large boggy scalp hematoma due to trauma, next step?
U/S
Or
CT
Mx of croup
Dexa x 1 dose
If mod-sev: nebulized epinephrine
If no response: other DDx
Bacterial tracheitis Mx
Intubation, ICU
ENT consult
AB (cloxacillin,…)
C&S
Epiglotitis Mx
DO NOT EXAMINE OROPHARYNX
immediate anesthesia, ENT call, intubate
Then IV fluids
AB
B/C
Mx of children asthma
O2 (if sat < 90% or PaO2 < 60%)
Salbutamol (by mask x3)
Steroid (systemic prednisolone/ dexa x 2 doses 24 h apart)
Ipratropium (if severe. Add to first 3 salbutamol doses)
MgSO4 ( if critically ill, not responding to bronchodilator/CS)
IV B2-agonist (if critically ill and not responding to above)
Mx of Febrile infant Without obvious focus
<28 d:
Admit
Full sepsis W/U
Treat empirically
28-90 d:
As above
But if meets Rochester criteria, partial sepsis w/u
> 90 d:
If toxic: admit, treat, full sepsis w/u
If non-toxic: investigate as indicated by Hx and PEx
Rochester criteria:
Non-toxic Previously well: (Term Home with mother No hyperbil No prior AB or hospitalization No chronic/ underlying illness) No focus of infection WBC 5000-15000 Bands <1500 Urine <10 WBC Stool <5 WBC
Full vs partial sepsis w/u
Full:
CBC, diff, blood C/S, urine C/S, LP
+/- stool C/S, CXR
Partial:
CBC, diff, blood C/S, urine C/S
+/- CXR
Febrile seizure features
6mo-6yr Fever Or Hx of recent fever Often positive FHx Normal neurological exam afterward No evidence of intracranial infection No Hx of previous non-febrile seizures Relatively well-looking after seizure
Mx of febrile seizure
Treat fever
Look for source of fever
Head and neck findings in favor of child abuse
Torn frenulum Dental injuries Bilateral black eyes Traumatic hair loss Diffuse severe CNS injury Retinal hemorrhage
Shaken baby syndrome
Diffuse brain injury
Subdural hemorrhage, SAH
Retinal hemorrhage
Minimal/no evidence of external trauma or associated bony fx
Skin injuries
Bites Bruises/burns in shape of an object Glove/stocking distribution of burns Bruises of various ages Bruises in protected areas
Bone injuries suggestive of child abuse
Rib fx without major trauma Femur fx < 1yr Spiral fx of long bones in non-ambulatory children Metaphyseal fx in infants Multiple fx of various ages Complex/multiple skull fractures
GI/GU injuries suggestive of child abuse
Chronic abdominal/perineal pain
Injury to genitals/rectum
STI/pregnancy
Recurrent vomiting or diarrhea