Embryology/ Limb Development Flashcards

1
Q

Embyonic Disk

A

Give rise to germ layers that form all the tissues and organs of the embryo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What gives the begining of morphogenesis

A

Gastrulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Establishment of the body of the Cylindrical Embryo

A

Is a result of the folding of the flat trilaminar embryonic disk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What surrounds the secondary oocyte

A

Zona Pellucida and Corona Radiata

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Cleavage

A

2 cell to 4 cell to 8 cells all happen in the uterine tube.
16-32 cells is classified as the morula

The morula enters the uterus considered a blastocyst

Blastocyst has inner cell mass called EMBRYOBLASTt and outer cell mass called TROPHOBLAST

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

When does implantation begin? Where does it occur?

A

It begins on the first week and ends on the second week. It implants on the posterior wall of the superior part as the zona pellucida dissapears

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What does the trophoblast become?

A
  1. Cytotrohpoblast
  2. Syncytiotrohoblst
    Note: #2 forms a blood filled lacunae that erodes the mothers endometrial blood vessels and establishes a uteroplacental circulation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are two types of abnormal pregnancies

A
  1. Ectopic Pregnancy
  2. Placenta previa (implantation in the inferior segment of the uterus near the internal os) In this case patients would present with vaginal bleeding.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Second Week of Development (Bilaminar Germ Disc)

A

Period of 2’s
1. Inner Cell Mass- becomes epiblast and hypoblast

  1. Outer Cell Mass- becomes Cytotrophoblast and Synctiotrophoblast
  2. Cavities form (2)- Amniotic Cavity and the Yolk sac cavity
  3. Extraembryonic (Lateral) Mesoderm splits- Somatic Layer and Splanchnic Layer
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Third Week of development (Trilaminar Germ Disc)

A

Period of Threes
1. Primitive Streak (Gastrulation gives us the Three Germ Layers)

  1. Primitive Node ( Neuralation gives us the Neural Plate, Neural Groove, and Neural Tube)
  2. Mesoderm on each side of the notochord (Paraxial gives us the intermediate mesoderm, the lateral plate mesoderm, and the neural crest cells
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What structure gives rise to all three germ layers

A

Epiblast. It is called gastrulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What structure gives the neural tube?

A

Ectoderm. It is called neuralation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What structure produces HCG

A

The Placenta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What two parts make up the placenta

A
The Villous Chorion (baby)
Decidua Basalis (Mom) 

Note: There are three different types of Decidua

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which structure will regress by the fourth month of pregnancy?

A

Cytotrophoblast. As a result the exchange from mother to baby an baby to mother takes place across the synctiotrophoblst and fetal endothelium.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Umbilical Cord

A

Umbilical vessels = 2 arteries plus LEFT umbilical vein

Ducts = 2 Ducts Allantois plus virelline duct (both of which will be atrophied

17
Q

When considering twins which structure must each baby have of it’s own regardless of whether they are monozygotic or dyzygotic twins?

A. Placenta
B. Chorion
C. Amnion
D. Yolk Sac

A

Amnion

18
Q

How many degrees is limb rotation

A

90 degrees

19
Q

Amelia

A

absence of an entire limb

20
Q

Meromelia

A

Absence of part of a limb

21
Q

Phocomelia

A

Short, poorly formed limb

22
Q

Polydactyly

A

Extra digit

23
Q

Syndactyly

A

Fusion of digits

24
Q

Lobster Claw Deformity

A

Middle digit is absent

25
Q

How do limb buds elongate

A

By proliferation of the mesenchyme

26
Q

Relationship between growth and rotation of limbs and cutaneous nerve supply.

A

Know that there is a relationship

27
Q

When does the initial growth of limbs occur

A

4-8 weeks

28
Q

Which limb buds develop first upper or lower

A

Upper by approximately 2 days

29
Q

AER (Apical Ectodermal Ridge)

A

has an inductive influence on the limb mesenchyme which promotes growth and development of the limbs
(PROXIMODISTSAL AIXS)

30
Q

How do limb buds elongate

A

By proliferation of the mesenchyme within them.

31
Q

The limb grows in how many different axes

A

proximal- distal
dorsal-ventral
posterior-anterior

32
Q

What genes and what signaling mechanisms are essential for the limb outgrowth carried out by AER?

A
FGF Signaling
HOX genes (retinoic acid and/or ethanol can effect the HOX genes)