Embryology Flashcards
What is the most critical period of pregnancy and why?
Embryonic period
All the major structures and systems are formed
Why is week 3 called the ‘week of 3s’?
3 cavities form (amniotic, yolk and chorionic) and 3 germ layers form in trilaminar disk (ectoderm, mesoderm, endoderm)
Define gastrulation
The process of establishing the 3 germ layers and hence the origin of all tissues of the body. Also setting the axes.
What does the primitive streak do?
Drives and coordinates gastrulation
Where is the primitive node located?
At the cranial end of the primitive streak
Where does the primitive streak appear?
The dorsal surface of the epiblast
In which direction does development proceed?
Cranial to caudal
How are the 3 germ layers formed?
By migration and invagination: epiblast divides and migrates up to edges of primitive streak, some new cells push through epiblast layer to create a new layer.
What defines the phylum Chordata?
Having a notochord
What is the notochord for?
basis of axial skeleton, drives formation of nervous system (drives neurulation), defines the midline and has an important signalling role
Define the axes in an embryo
Anterior - towards head
Posterior - towards feet
Dorsal - back
Ventral - front
Which tissues are derived from the ectoderm?
Organs and structures that maintain contact with the outside world.
Eg. Nervous system, epidermis
Which tissues are derived from the mesoderm?
Supporting tissues
Eg. Muscle, cartilage, bone, vascular system
Which tissues are derived from the endoderm?
Internal structures
Eg. Epithelial linings, parenchyma of glands
What is situs inversus?
A congenital birth defect that means that the body is the mirror image of what it should be.
This results from immobile cilia during the embryonic period but has no associated morbidity.
How do monozygotic and dizygotic twins arise?
Monozygotic - a single fertilised oocyte
Dizygotic - 2 fertilised oocytes
What is teratogenesis?
The process through which normal embryonic development is disrupted.
Name some teratogenic agents
Thalidomide, Rubella, Alcohol and Therapeutic drugs (eg. Warfarin)
How is the neural plate formed?
The notochord releases signals that affect the ectoderm. The ectoderm thickens and forms a slipper-shaped neural plate.
How is the neural tube formed?
The edges of the neural plate elevate out of plane and curl towards each other forming a tube.
Where is the paraxial mesoderm?
Around the notochord and neural tube
What are the two types of lateral plate mesoderm?
Somatic and splanchnic
What does somatic mesoderm go on to form?
Connective tissues of limbs
What does splanchnic mesoderm go on to form?
Smooth musculature, connective tissues and vasculature of gut
What are somites?
The organisation of paraxial mesoderm into segments. The segments appear in craniocaudal sequence at 3 pairs per day.
Where does dermomyotome form and what will it become?
Dorsally
Skin and muscle tissue
What happens to the myotome?
It proliferates and migrates
What happens to the dermatome?
It disperses
What does the segmentation organisation of the mesoderm give rise to?
Repeating structures
Eg. Vertebrae, ribs, intercostal muscles
What innervates the epimere?
Dorsal branch of spinal nerve