Embryology 2 Flashcards
GASTRULATION and NEURULATION
Formation of germ layers
Formation of neural tube
Describe the location of the Primitive streak
formed in the midline of the epiblast by the dipping in of cells (invagination)
Provides an axis
Describe the 3 germ and type of disc
Ectoderm
Mesoderm
Endoderm
Trilaminar disc
*Gastrulation
What remnant is the nucleous pulposis of?
Notochord
What are the three parts the mesoderm separates into?
Paraxial, intermediate and lateral
What does dermtome,myotome and sclerotome form?
Dermtome dermis of skin
Myotome muscles
Sclerotome bones including vertebrae
Describe the 3 parts of the somite
Dermatome
Myotome
Sclerotome
Describe the intermediate plate mesoderm
Urogenital system (kidneys, reproductive)
Define teratology
Study of when things go wrong during development
Congenital rubella
caused by contraction of german measles when pregnant
Describe the 3 factors the risk posed by a teratogen depends on
Exposure during critical periods of development
Dosage of drug/chemical/factor
Genetic constitution of embryo ie some more susceptible than others at equivalent doses etc
Diagnosis of malformations prenatal
Blood - AFP
Ultrasound scan – 12 week anomaly scan
Invasive tests: chorionic villus sampling and amniocentesis
Diagnosis of malformations postnatal
Hip stability
Testes (descent)
Fingers and toes
Hearing