Embryology Flashcards
Describe the normal development of the kidney
pronephros- early stage, non-functional
- develops and disappears in week 4
mesonephros
-20 paired tubule that makes some urine in week 5
-contributes to obliteration of cloaca and bladder formation
metanephros
-starts at 6 weeks
-forms the actual kidney in the pelvis then migrates to the lumbar region
-produces urine by 9-10 weeks
-attaches the elongated ureteric bud to the urogenital sinus
What are the embryologic origins of the kidney and ureters?
mesonephric ducts
What are the embryologic origins of bladder?
urogenital sinus for all parts except the trigone
trigone-mesonephric ducts.
What is embrologic origin of the uterus and tubes?
paramesonephric ducts
What is the embryologic origin of the male genitalia?
mesonephric ducts (wolffian ducts)
SRY region of the Y chormosome produces mullerian inhibiting substance.
What is the embryologic origin of the bladder, urethra, lower 2/3 of the vagina, vestibule, and rectum?
urogenital sinus
Gonadal development
germ cells migrate to the gonadal ridge through the primitive streak
no migrate of germ cells = no gonads
germ cells multiple into several million by month 4
Name the embryologic origin of this vulvar structure:
Clitoris
Clitoris: genital tubercle
Name the embryologic origin of this vulvar structure:
Labia majora
Labia majora: labioscrotal swellings
Name the embryologic origin of this vulvar structure:
labia minora
labia minora: genital tubercle
name the embryologic origin of the urethra.
urogenital sinus
What structures are formed by the urogenital sinus?
bladder, urethra, paraurethral glands, lower 2/3 of vagina
name the embryologic origin of the ureter.
ureteric bud
McIndoe
success rate
complications and overall rate
success 80-90%
<5% complication rate
same for vecchietti
davidov uses a peritoneal graft
in patients with longitudinal septum, what percentage are found to have bicornuate uterine anamoly
60%
What causes transverse septum?
failure of fusion of paramesonephric duct and urogentinal sinus
what is the most common anomaly of the female reproductive tract?
imperforate hymen
when should you repair imperforate hymen?
time of high estrogen- neonatal or post pubertal, but premenarchal
