Elimination

Question 1

Gastric Juice Components

Answer 1

HCL (parietal cells), Pepsinogen (gastric chief cells) and Histamine (enteroendocrine cells)

Question 2

Three Ways to decrease acidity in the stomach

Answer 2

1. h2 receptor antagonism (parietal cell receptor)
2. Proton Pump Inhibito
3. Antacids

Question 3

H2 Receptor Antagonists

Answer 3

Histamine 2 receptor antagonism. blocks h2 selectively and decreases HCL production 
Drugs: quick acting
Ranitidine (zantac)
Cimetidine (Tegamet)
Famotidine (pepcid)

Question 4

PPI’s

Answer 4

Bind to H, K and ATPase enzymes to inhibit the proton pump (inhibits HCL secretion) higher efficacy than h2, longer halflife. 
Meds:
Omeprazole (losec)
Lansoprazole (prevacid)
Pantoprazole (pantoloc)

Question 5

Antacids

Answer 5

increase stomach pH.
Meds: 
Aluminum hydroxide (ampojel)
Magnesium Hydroxide (milk of magnesia)
Calcium Carbonate (tums, calctrate)
Pepto-bismol
Rolaids

Question 6

Side Effects of Aluminum and Magnesium

Answer 6

Aluminum: constipation
Magnesium: diarrhea

Question 7

PUD Therapy:

Answer 7

1st Line:
Antibiotics x2 weeks - amoxicillan, clarithromycin and metronidazole (flagyl) + PPI (losec(omeprazole))

Bismuth Therapy:
antibiotics + Peptobismol (inhibits bacterial growth and mucosal adhesion)