elimination

Question 1

elim vs sn

Answer 1

-both have leaving groups but sn replaces it w nu
-often compete
-emilination= FORM ALKENE

Question 2

formation of alkene

Answer 2

caused by the loss of the beta hydrogen

Question 3

two main mechanism

Answer 3

e1 and e2

Question 4

e2

Answer 4

bimolecular
-involves the substrate and the base in one single step

Question 5

where will the double bond form?

Answer 5

-all about regiochemistry
-how many groups on each double bond

Question 6

zatziev product

Answer 6

-more substituted alkene
-most times is the major product UNLESS IT IS A BBB
-ALL ABOUT WHERE THE RXN TAKES PLACE

Question 7

BBB

Answer 7

chose hofman product/ less sub
-tbuok and lda

Question 8

product of e2 reaction

Answer 8

-can be controlled based on which base you use cause one leads to more sub and one leads to less sub product

Question 9

identical beta h positions

Answer 9

-regiochemistry is not an issue, no matter where rxn happens same outcome
-stereochem important
-if cis and trans are product, trans is favored

Question 10

steroselective e2

Answer 10

-cis and trans are the product and they both have the same regiochemistry
-trans is favored
-results in a mixture

Question 11

stereospecific e2

Answer 11

-antiperiplanar
-results in one alkene
-draw newman projection to make sure they are in a line
-does not produce stereoisomers

Question 12

one proton

Answer 12

-is stereospecific, will only get one alkene
-draw newman projection and make sure it is aniperiplanar

Question 13

newman projection

Answer 13

-use to determine the stereoisomer product of e2 reaction

Question 14

e1

Answer 14

two steps
-leaving group leaves
-lose of the proton
-the base is not involved in step one therefore unimolecular all about the substrate
-compete with sn1 and product is a mixture

Question 15

e1 alkyl halids

Answer 15

prefer secondary and tertiary
-primary will not go e1

Question 16

sn2

Answer 16

will not be tertiary (too bulky)
-but e2 can be tertiarty bc there is not attack

Question 17

e2 alkyl halide

Answer 17

tertiary is fastest

Question 18

oh

Answer 18

bad leaving group

Question 19

e1 of an alcohol

Answer 19

there will be a protonation step first because oh is a bad leaving group
-strong acid used to protonate
-product is h2o+ which is an excellent leaving group

Question 20

e1 and e2

Answer 20

prefer zatsev product as the major product

Question 21

e1 product

Answer 21

CAN NOT BE CONTROLLED BY USING A BBB

Question 22

regiochemical outcome

Answer 22

where the alkene bond will go which will lead to zaitzev or hoffman

Question 23

are e1 reactions stereospecific

Answer 23

NO
-do not need antiperiplanarity to run reaction
-they are stereoselective when cis and trans happen

Question 24

stereospecific

Answer 24

changing reactant changes product
-only e2

Question 25

stereoselective

Answer 25

-choice btween 2 paths that lead to 2 products (cis and trans)

Question 26

three steps to determine products

Answer 26

-function of the reagent -analyze substrate and expected mechanisms -regiochemical and stereochemical requirements

Question 27

reagent

Answer 27

-is it functioning as a nu or as a base

Question 28

when are nucleophilicity and basicity parallel?

Answer 28

when they are in the same row of the periodic table -same row, more electroneg= weaker base

Question 29

hn- vs ho-

Answer 29

ho- is the weaker base because the oxygen is more elctronegative and stabalizes charge better than nitrogen

Question 30

same column

Answer 30

-basicity and nu are not parallel -OH- vs SH-, OH- is the stronger base because it is smaller and sh is the stronger nu bc it can polarize charge bc of its size

Question 31

halides especially iodine

Answer 31

function mostly as nu= substitution

Question 32

strong nu

Answer 32

highly polarizable (big)

Question 33

strong base

Answer 33

e2

Question 34

so4

Answer 34

e1

Question 35

vicinal dihalide

Answer 35

halides on adjacent carbons -goes to most acidic protons (the ones that have the halides because they have partial positives)

Question 36

double hydrohalogenation

Answer 36

e2 reaction twice that synthesizes an alkyne -use the base twice

Question 37

nh2

Answer 37

strong base

Question 38

geminal dihalide

Answer 38

halogens are on the same carbon (gemini twins same mother carbon) -must be alpha to terminus (next to terminus) -need excess base -go for terminal protons

Question 39

dehydrohalogenation e2 reactions

Answer 39

-double hydrohalogenations to geminal dihalides or vicinal dihalides