Electrochemical Impulses and Synapse Flashcards
Electrochemical Impulses
Wave of depolarization sent along the axon primarily involving the movement of sodium and potassium ions across the cell membrane
Resting Neuron
Neuron not conducting signals that has potential energy due to the charge difference inside and outside the cell - cell is polarized at -70 mV
Resting Neuron: Why Polarized?
- Large negatively charged molecules inside the cell (proteins, phosphates, and sulfates)
- K+ channel is slightly open, allowing K+ ions to freely flow out of cell
Action Potential
When the axon is sufficiently stimulated (threshold is reached), Na+ channels open and K+ channels close, letting in Na+ ions; cell is depolarized = +40 mV
Transfer of Action Potential
Na+ ions attracted to negatively charged molecules further down axon, so they move along axon; triggers further sodium channels to open and initiates more action potentials
Repolarization
Na+ channels close and K+ channels open to let out K+ ions to restore negative internal charge - cell is hyperpolarized = -90 mV
Resting Balance
Resting potential is restored through the sodium-potassium pump, which transports 2 K+ ions in for every 3 Na+ ions it transports out; cell is back at -70 mV; refractory period = time it takes for neuron to reset back to resting before next action potential
Synapse
Gap between presynaptic neuron (neuron sending signal), and postsynaptic neuron (neuron receiving signal)
Transmitting Message Between Neurons
When stimulus reaches end of axon, calcium channels open to let in C2+ ions which cause vesicles at end of axon to release neurotransmitters (like acetylcholine) into synapse through exocytosis; neurotransmitters bind to sodium receptors on dendrites of postsynaptic neuron, causing nearby sodium channel to open, letting in Na+ ions, triggering wave of depolarization in that neuron - cholinesterase also in synapse to break down acetylcholine to prevent message from constantly being sent and from neuron being in constant state of depolarization