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MKBK2 > Eikozanoidi > Flashcards

Eikozanoidi Flashcards

1
Q

koji je glavni prekursor eikosanoidnih hormona

A

arahidonat

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2
Q

lipooksigenaza katalizira

A

prvi korak u linearnoj sintezi leukotriena

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3
Q

ciklooksigenaza ili

A

proslaglandin H2 sintaza

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4
Q

ciklooksigennaza katalizira

A

cikličku sintezi prostaglandina, prostaciklina i tromboksana

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5
Q

kak djeluju eikosanoidi

A

lokalno

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6
Q

eikosanoidi djeluju na

A

krvni tlak, rast, zgrušavanje krvi, u upalnim procesima

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7
Q

odkud dobivamo arahidonsku kiselinu

A

iz hrane
djelovanjem fosfolipaze A2 na fosfolipide st. membrane

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8
Q

kakvu aktivnost ima ciklooksigenaza

A

ciklooksidaznu i peroksidaznu

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9
Q

izoenzimi ciklooksigenaze

A

COX-1 i COX-2

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10
Q

uloge prostaglandina

A

regulacija zgrušavanja krvi, upale, boli, kontrakcije maternice (COX-2), sekrecije mucina (COX-1)

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11
Q

kak aspirin djeluje na tromboksan

A

niske doze aspirina inhibiraju sintezu tromboksana i sprečavaju agregaciju trombocita

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12
Q

protuupalni kortikosteroidni lijekovi inhibiraju

A

COX2

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13
Q

tromboksanima su antagonisti

A

prostaciklini

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14
Q

gdje nastaju i kak djeluju tromboksani

A

trombociti
stezanje krvnih žila i sprečavanje agregacije trombocita

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15
Q

gdje nastaju i kak djeluju prostaciklini

A

stijenke krvih žila
inhibiraju agregaciju trombocita

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16
Q

kak djeluju leukotrieni

A

konstriktori mišića, bronha, regulatori bolesti

MKBK2 (25 decks)

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