Eating Disorders Part 1 Flashcards
What are the 6 types of eating disorders?
- Anorexia Nervosa
- Bulimia Nervosa
- Binge Eating Disorder (most common)
- Avoidant/Restrictive Food Intake Disorder
- Other Specified Eating Disorder
- Unspecified Eating Disorder
What are the characteristics of Anorexia Nervosa?
-
An intense pursuit of weight loss & self-induced starvation
- Fear of becoming obese
- Engages in dieting & excessive exercise
- Paradoxically focused on food
-
A disturbance in body image
- Belief they are fat even though they are thin
- **Medical signs/symptoms of starvation **
Anorexia Nervosa according to DSM 5
- Removal of less than 85th percentile of IBW criteria
- “significantly low weight”
- Intense fear of gaining weight or behaviors that interfere w/ weight gain
- Disturbance of how one perceives their body
- _Amenorrhea criteria removed _
Anorexia Nervosa
Subtypes
Severity (BMI)
-
Subtypes
- Restricting type
- Binge-eating/purging type
-
Severity (BMI)
- BMI = weight (kg)/height (m2)
- Mild: >17
- Moderate: 16-16.99
- Severe: 15-15.99
- Extreme: <15
What is the definition of binging/purging?
- Eating a large amt of food in a short period of time
- Engaging in compensatory behavior to get rid of the food or weight
- Feelings of loss of control during the episode
What are the vital sign changes with starvation?
- Hypotension
- Bradycardia
- Hypothermia
Starvation on organ systems
- Cardiac
- Skeletal
- Endocrine
- Dermatology
- Hematologic
- GI
- Neurologic
- Cardiac: bradycardia, hypotension, syncope, EKG changes, arrhythmias & sudden death
- Skeletal: Osteopenia, osteoporosis
-
Endocrine
- Hormonal changes: decreased LH, FSH & estradiol, abnormal TSH
- Cold intolerance, hypothermia
- Decreased libido, amenorrhea
- Dermatology: dry skin, alopecia, lanugo (fine baby-like hair over the body)
- Hematologic: pancytopenia, anemia, leukopenia
- GI: delayed gastric emptying, constipation
- Neurologic: fatigue, weakness, reduction in brain mass volume & cognitive deterioration
Epidemiology of Anorexia Nervosa
- Females > males (1:10)
- Onset usually in mid-teens, increasing in pre-adolescents
- 1% of population, 5% of the population show subclinical signs
- Higher SCE & US vs. other developed countries, but equalizing
What is the etiology of Anorexia Nervosa?
- Multifactoral
- Biological, psychological & social factors
- Different for almost every patient
- Dieting is #1 risk factor
- From normal eating to eating disorders (picture)

Biological Factors of Anorexia Nervosa
Genetic
Hormonal, biochemical
- Genetic
- Higher rates in monozygotic twins
- Strong FaHx for mood disorders
- Hormonal, biochemical & starvation effects
- Associated w/ onset of puberty
- Endorphin increases
- Hypothalamic-pituitary-adrenal axis changes
- NT: decreased NE turnover, decreased dopamine response, serotonin increases w/ food
**Psychological Factors of Anorexia Nervosa **
- Temperament
- Control Issues
- Maturation fears
- Independence
- Beliefs
- Temperament – perfectionist, harm avoidant, high-achieving
- Control issues – feeling helpless, not able to establish autonomy
- Maturation fears – fear of becoming an adult, being shapely or sexual
- Demands to increase independence
- Overwhelming, focuses on food vs. “normal” activities
- Beliefs – moral desires are greedy/unacceptable
Social factors of Anorexia Nervosa
- Media influence
- Obesity education
- Family concerns about weight
- Teasing about weight
- Dieting information
- Performance pressures in sports
- Interfamily conflicts
- Close but troubled to hostile, chaotic, isolative, controlling, not nurturing, not empathic (esp. binge-purge type)
What do you need to rule out when diagnosing Anorexia Nervosa?
How is this complicated?
Lab tests?
- Rule out
- Brain tumor or cancer
- Other psychiatric disorders: depression, somatization, schizophrenia, bulimia
- Complicated by
- Denial, secrecy
- Disinterest or resistance to treatment
- No laboratory tests “diagnose” AN, but for medical assessment
- CBC, electrolytes, magnesium, phosphorus, FSH/LH/estradiol, thyroid, LFTs, amylase, UDS, specific panels (i.e. diuretics), ECG, urine pregnancy
______ ______ is the most lethal psychiatric disorder
**Anorexia Nervosa **
- May require inpatient medical stabilization
- Don’t ignore weight loss in teenage patients!
What are the treatment options for Anorexia Nervosa?
- Hospitalization
- Psychotherapy
- Psychopharmacology
Hospitalization for Anorexia Nervosa
Treatment & Goals
- Food is the best medicine!
- May require hospitalization
- If nutritionally unstable: dehydration, electrolyte abnormalities
- Goal: reinstate nutrition, correct metabolic abnormalities, maintain structure/cooperation
- Treatment team is KEY
- Primary care physician, Psychiatrist, Dietician, Psychotherapist
What is Refeeding Syndrome?
- Fluid & electrolytes shift during nutritional rehabilitation
- Risk is related to
- Amt of weight lost during the current episode
- Rapidity of weight restoration
- Potentially life-threatening
- Hypophosphatemia, delirium, arrhythmias, cardiac arrest
What are the forms of psychotherapy used to treat Anorexia Nervosa?
- Forms: family, individual & group therapy (inpatient & ED)
- Methods
-
“Maudsley” Family Based Treatment
- Parents play an active role in restoring weight & gradually hand over control back to the patient
-
Cognitive behavioral therapy (CBT)
- Address cognitive distortions
-
Dialectical behavioral therapy (DBT)
- Address treatment interfering behaviors
-
“Maudsley” Family Based Treatment
- Goal: stabilize & improve primary relationships
How is psychopharmacology used for Anorexia Nervosa?
- No medications are indicated or have consistently shown benefit for the core symptoms of anorexia nervosa
- Medications are generally used to treat psychiatric comorbidities (depression, social phobia, OCD)
What is the prognosis of Anorexia Nervosa?
Mortality rate?
-
Good to moderate in 75% of patients
- ¼ have complete recovery
- ½ have overall good function despite ongoing issues
- Some continue a waxing & waning course
- Increased risk of poor prognosis & death
- Persisting food obsessions
- Complication by bulimia
- Low albumin, very low weight
- **Mortality: 7-18% **
What are the characteristics of Bulimia Nervosa?
- Episodes of overeating
- Compensatory behavior to prevent weight gain
- May engage in purging or excessive exercise
- May have normal weight, by overweight or obese
- Clinical signs/symptoms
Bulimia Nervosa according to DSM 5
- Recurrent episodes of binge eating following by inappropriate compensatory behavior in order to prevent weight gain
- Episodes occur at least 1X/wk for 3 mo
-
Severity can be specified (based on compensatory behaviors/wk)
- 1-3 = mild
- 4-7 = moderate
- 8-13 = severe
- 14+ = extreme
What are the compensatory behaviors of Bulimia Nervosa?
-
Purging
- Misuse of laxatives, diuretics, enemas
- Vomiting
-
Other
- Excessive exercise
- Restrictive dieting
- Skipping meals
What are some clinical signs of Bulimia Nervosa on observation?
- Swollen cheeks: parotid gland hypertrophy/infection
- Metacarpal-phalangeal calluses (Russel’s signs): abrasions on knuckles from scraping against teeth
- Dental erosions & caries: from gastric acid in the mouth
- Front teeth that are chipped or ragged & “moth-eaten”
**Bulimia Nervosa **
- Labs
- GI
- Cardiac
- Endocrine
- Neuro
- Labs: fluid & electrolyte imbalance
- GI: GERD, esophageal varices or rupture; melanoisis coli (laxative use)
- Cardiac: arrhythmias & myopathies
- Endocrine: menstrual abnormalities
- Neuro: neuropathy, fatigue, cognitive slowing, seizures
What are some common lab abnormalities of Bulimia Nervosa?
-
Associated w/ vomiting & diuretic use
- Metabolic alkalosis: low K+, low Na2+, high bicarb
- Hypochloremia
-
Associated w/ laxative abuse
- Hyperchloremic metabolic acidosis
- Low K+, high chloride, low bicarb
-
Other
- Low magnesium
- Elevated serum amylase level, generally normal lipase level
Hypokalemia in Bulimia Nervosa
- Excessive vomiting leads to loss of K+
- potentially lethal arrhythmias
- If purging >3X/day refer for inpatient evaluation
What is the epidemiology of Bulimia Nervosa?
-
More common than Anorexia Nervosa
- 1-3% of population
- Onset is generally later than in AN
- late adolescence/early adulthood
- Surveys of college women: 20-40% report binging & purging
What are the biological factors of Bulimia Nervosa?
-
Genetic
- 1st degree relatives w/ BN or depression
-
Biochemical
- Increased rate of mood disorders & impulse control disorders
- More responsive to serotonin fluctuations
- Endorphin release (reinforces vomiting)
What are the psychological factors of Bulimia Nervosa?
- Temperament
- Overachiever, competitive
- Secretive, ego-dystonic, self-critical
- Outgoing, angry, impulsive
- Associated w/ depression, alcohol & other substance use disorders, impulse control disorders, personality disorders, emotional lability, anxiety, dissociative disorders, history of abuse
What are the social factors of Bulimia Nervosa?
- Media influence
- Anti-obesity education
- Weight teasing/bullying
- Family conflict
- Less close, more confrontational
- Control issues
- Neglectful/rejecting
What do you have to rule out when diagnosing Bulimia Nervosa? Lab tests?
-
Rule out
- Neurologic disorders: seizures, tumors, Kluver-Bucy, Klein-Levin
- Other psychiatric diagnoses, comorbidities?
- Can be complicated by denial & secrecy but tend to seek treatment
- No lab tests to diagnose but for medical assessment (similar to AN)
How is Bulimia Nervosa treated?
- Most don’t require hospitalization
-
Most effective treatment is therapy
- Cognitive Behavioral Therapy (CBT)
- Dialectical Behavioral Therapy (DBT)
- Family Therapy
- Group Therapy (inpatient or partial hospitalization)
- SSRI antidepressant medication have shown to be effective
- Fluoxetine (Prozac) is the only FDA approved agent
- Bupropion (Wellbutrin) is contraindicated b/c of increased seizure risk
What is the prognosis of Bulimia Nervosa compared to Anorexia Nervosa?
- Higher potential for full recovery
- If untreated, remains chronic
- If complicated by substance use issues, poor prognosis