E-stim for tissue healing Flashcards

1
Q

Wound healing: inflammatory stage

A
  • hemostasis: blood clotting due to platelets binding and adhering to periphery of wound
  • phagocytosis- driven by macrophages, monocytes, inactive neutraphils; breakdown and elimination of bacteria/foreign substances and -Autolysis=breakdown of other foreign debris
  • Fibroblast migration
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2
Q

Wound healing: hemostasis

A
  • blood clotting occurs platelets bind and adhere to collagen of periphery of injured tissue
  • platelets attract other cells> kemotatic influence
  • some cells attracted= macrophages, monocytes, and inactive neutraphils
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3
Q

Wound healing: proliferation stage

A
  • collagen synthesis
  • angiogenesis= new BVs; critical for nutrients for healing
  • epithelialization
  • wound contraction
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4
Q

Wound healing: maturation stage

A
  • collagen lysis

- collagen replacement

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5
Q

Factors that impede wound healing

A
  • some systemic medications
    • corticosteriods, aspirin, indomethacin?
  • some topical medications
  • *iodine- can kill cells that help with healing
  • malnutrition
  • prolonged pressure or stretch-
    • interrupt development of capillaries (angiogenesis) disrupting blood supply
  • infection
  • immunodificency
    • impairment to inflammatory response
  • smoking
  • dryness or necrotic tissue
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6
Q

Assessment of chronic wounds:

A
Size
- Surface area: 
**tape measure width and length of wound @ greatest pt
**most commonly measured
-depth
-volume
** look at total volume of wound
** create (-) mold of wound, volume measured by displacement of model
description of wound base
assessment of periwound tissue
Drainage of wound
- clear or pinkage drainage w/out odor= inflammatory stage
- yellow/cloudy drainage= infection
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7
Q

Types of chronic wounds

A
  • Pressure sores
  • arterial insufficiency ulcers
  • venous insufficiency ulcers
  • Diabetic ulcers
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8
Q

Pressure sore

A
  • Area of local tissue loss due to prolonged tissue compression between boney prominences and external surfaces
  • Common locations
    • sacrum, heels, ischial tuberosity, greater trochanter, malleoli
  • etiology:
    • compression of tissue reduces blood perfusion in tissues and produces necrosis
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9
Q

Stages of pressure sores

A
  • Stage 1: non-blanchable erythema of intact skin
  • Stage II: partial thickness skin loss to epidermis, dermis, or both
  • Stage III: full thickness skin loss including damage to subcutaneous tissue
  • Stage IV: full thickness skin loss with destruction or damage to muscle, bone, or support structures
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10
Q

Arterial insufficiency ulcers

A
  • area of local tissue loss due to arterial blood supply deficiency
  • common locations:
    • on foot, over malleoli, toe joints, lateral foot border
  • Etiology:
    • arteriosclerosis, arterial occlusion (ex thrombosis), arterial disruption
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11
Q

Venous insufficiency ulcers

A
  • area of local blood loss due to deficiency in venous drainage
  • common locations:
    • above the ankle, medial lower leg
  • etiology:
  • *sustained venous hypertension, venous valvular dysfunction
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12
Q

Diabetic ulcers

A
  • area of local tissue loss due to sensory neuropathy and arterial blood supply deficiency
  • common locations:
  • *plantar surface of foot, over heel, lateral border of foot, plantar surface of metatarsal heads
  • etiology:
    • tissue trauma in insensate tissue, PVD
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13
Q

biological effect of electricity: electrochemical

A

Formation of new chemical compounds

  • negative electrode
    • 2 Na + 2 H20 > 2 NaOH + H2 (alkaline)
  • positive electrode
    • 2 Cl2 + 2H20 > 4 HCL + O2 (acid)
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14
Q

biological effect of electricity: electrophysical

A
  • electrokinetic effect- ion movement
  • negative electrode = attraction of + ions, drive (-) electrodes away
  • ex. depolarization of excitable membrane
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15
Q

biological effect of electricity: electrothermal

A
  • Microvibration of charged particles produces heat
  • H= 0.24 x I^2 x R x t
    • H=heat produced
    • I= RMS amp current
    • R= impedance of tissue
    • t= time
  • High RMS, high skin impedance and prolonged treatment time increase thermal effect
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16
Q

Physiological effects of E-Stim that benefit wound healing

A
  • Galvanotaxis= ability to attract ions
  • collagen synthesis
  • proliferation of fibroblasts
  • angiogenesis and wound microperfusion
  • bacteriacidial
  • enhanced rate of epithelialization
  • enhanced blood flow to wound
17
Q

Galvanotaxis of cells during the phases of healing: inflammatory

A
  • macrophages- negative > phagocytosis

- inactive neutrophils- negative > autolysis

18
Q

Galvanotaxis of cells during the phases of healing: proliferation

A

-Fibroblasts- positive > collagen fomation

19
Q

Galvanotaxis of cells during the phases of healing: maturation

A
  • myofibroblasts- positive > wound contraction
  • keratinocytes- positive > epithelialization
  • epidermal - negative > epithelialization
20
Q

Collagen Synthesis and Proliferation of Fibroblasts study

A
  • Stimulation of human fibroblast cell culture
  • cathode > protein synthesis in fibroblasts increased 160% over control
  • parameters: 50-75 V and 150 pps
21
Q

Stimulation of Angiogenesis and Wound Microperfusion study

A
  • Cathode 7-14 treatments followed by anode 3-10 days followed by cathode
  • 44% increase in capillary density
  • 82% increase in transcutaneous oxygen partial pressure
22
Q

Enhancing the Rate of Epithelialization study

A
  • Partial thickness wounds in pigs
  • Anode x 7 days or cathode day 1 and anode x 6 days  wound closure in 6 days
  • Cathode  62% closure in 6 days
23
Q

Enhanced Blood Flow to Wound study

A
  • Rectangular, balanced, biphasic pulsed current
  • 250μs pulse duration, 30 pps x 5 minutes
  • 50% greater ave blood flow measured with laser doppler
24
Q

Types of current used in wound healing: low intensity direct current (DC)

A
  • Amplitude: 200-800 mA
  • tx duration: 1-2 hours
  • tx per day: 1-3 per day
  • Tx days per week: 5-7 days per week
25
Q

Types of current used in wound healing: high volt pulsed current (HVPC)

A
  • Pulse amp: 100-150 V peak
  • pulse duration: 100 usec
  • pulse frequency: 30-130 pps
  • mode: continuous
  • tx duration: 30-60 mins
  • tx per day: 1-2
  • tx day per week: 5-7 days
26
Q

HVPC

A

Twin peaked monophasic pulse

  • pair of monophasic spike like waveforms
  • almost instantaneous rise followed by exponential decline
  • pulse duration: short
    • 100-200 usec
27
Q

Types of current used in wound healing: rectangular monophasic pulsed current (RMPC)

A
  • Pulse amp: 30-35 mA peak
  • pulse duration: 150 usec
  • pulse frequency: 64-128 pps
  • mode: continuous
  • tx duration: 30 mins
  • tx per day: 2
  • tx days per week: 7 days
28
Q

Types of current used in wound healing: biphasic pulsed current (rectangular asymmetric)

A
  • pulse amp: strong sensory; just less than motor level
  • pulse duration: 100 usec
  • pulse frequency: 50 pps
  • mode: continuous
  • tx duration: 30 mins
  • tx per day: 3
  • tx days per week: 5-7 days
29
Q

The human battery

A
  • outside of skin has negative chare
  • inside of skin has positive charge
  • with injury, polarity shifts
    • outside> positive
    • inside> negative
30
Q

Polarity used in wound healing: protocol 1

A
  • Protocol 1

* * cathode over wound days 1-5

31
Q

Polarity used in wound healing: protocol 2

A
  • Protocol 2
    • cathode over wound if infected with E. coli, P aeruginosa
    • anode over wound if infected with S. aureas
32
Q

Polarity used in wound healing: protocol 3

A

Based upon type of healing clinician wants to induce

  • anode: attract macrophages, and neutrophils to stimulate phageocytosis and autolysis
  • cathode: attract fibroblasts to increase granulation tissue; stimulate myofibroblast to increase wound contraction; stimulate keratinocytes to increase rate of re-epithelialization
33
Q

Polarity Used in Wound Healing: protocol 4

A

Based upon electrochemical response in tissues being stimulated
- Cathode – solubilize, liquefy, soften tissue

-Anode – stimulate epithelialization

34
Q

Cathode – NegativeTherapeutic Effects

A
  • Increased blood flow
  • Galvanotaxic for
  • *activated neutrophils, fibroblasts, lymphocytes, platelets, mast cells, keratinocytes
  • Enhances growth of granulation tissue
  • Induces epidermal cell migration
  • Antimicrobial
35
Q

Anode – Positive Therapeutic Effects

A
  • Galvanotaxic for:
  • *macrophages, epidermal cells, inactive neutrophils,
  • Promoted growth and reorganization of epithelial cells
  • Decreases mast cells in healing wounds
  • Vasoconstriction
  • Decreases blood flow
  • Antimicrobial
36
Q

Physiological and Therapuetic Effects

A

Reduce edema formed with acute injury and inflammation

  • -Negative pole (Theories)
  • *Repel negatively charged serum proteins
  • *Reduce microvessel diameter
  • *Reduce pore size
37
Q

Edema Reduction Parameters

A
  • Waveform: HVPC
  • Pulse Duration: 40 – 100 μsec.
  • Polarity: Negative
  • Frequency: 100 – 200 pps
  • On/off time: continuous
  • Current amplitude: comfortable sensory
  • Treatment time: 20 – 30 minutes