DTP Hydrocortisone

Question 1

Hydrocortisone Drug class

Answer 1

Corticosteroid

Question 2

Hydrocortisone Pharmacology

Answer 2

• Produces an anti-inflammatory process.
  This inhibits the accumulation of inflammatory cells at inflammation sites, phagocytosis,
  lysosomal enzyme release and synthesis and/or release of mediators of inflammation.
• Prevents and suppresses cell mediated immune reactions.

Question 3

Hydrocortisone Metabolism

Answer 3

Hepatic

Question 4

Hydrocortisone Indications

Answer 4

• Symptomatic adrenal insufficiency
(with a known history of Addison’s disease,
congenital adrenal hyperplasia, pan-hypopituitarism or long-term
steroid administration)
• (CCP) Moderate OR severe asthma
• (CCP) Acute exacerbation of COPD (with evidence
of respiratory distress)
• (CCP) Severe allergic reaction OR anaphylaxis
(requiring adrenaline administration)

Question 5

Hydrocortisone Contraindications

Answer 5

KSAR

Question 6

Hydrocortisone Precautions

Answer 6

Hypertension

Question 7

Hydrocortisone Side effects

Answer 7

Nil

Question 8

Hydrocortisone Presentation

Answer 8

Vial, 100 mg hydrocortisone (Solu-Cortef ®)

Question 9

Hydrocortisone Onset (IV)

Answer 9

1 – 2 hours

Question 10

Hydrocortisone Duration (IV)

Answer 10

6 – 12 hours

Question 11

Hydrocortisone Half-life (elimination)

Answer 11

6 – 8 hours

Question 12

Hydrocortisone Schedule

Answer 12

S4 (Restricted drugs).

Question 13

Hydrocortisone preparation

Answer 13

• Each 100 mg hydrocortisone vial is to be reconstituted with 2 mL of water for injection

Question 14

Adult IM Dose for Symptomatic Adrenal Insufficiency

Hx Addison’s Disease; Congenital adrenal hyperplasia; Pan-hypopituitarism; Long-term steroid administration

Answer 14

100mg single dose

Question 15

Adult IV Dose for Symptomatic Adrenal Insufficiency

Hx Addison’s Disease; Congenital adrenal hyperplasia; Pan-hypopituitarism; Long-term steroid administration

Answer 15

100mg 1min push, single dose

Question 16

Paediatric IM Dose for Symptomatic Adrenal Insufficiency

Hx Addison’s Disease; Congenital adrenal hyperplasia; Pan-hypopituitarism; Long-term steroid administration

Answer 16

5mg/kg, SMD 100mg, single dose

Question 17

Paediatric IV Dose for Symptomatic Adrenal Insufficiency

Hx Addison’s Disease; Congenital adrenal hyperplasia; Pan-hypopituitarism; Long-term steroid administration

Answer 17

5mg/kg 1min push, SMD 100mg, single dose