DTP Ceftriaxone

Question 1

Ceftriaxone drug class

Answer 1

Antibiotic

Question 2

Pharmacology of ceftriaxone

Answer 2

Ceftriaxone is a third generation cephalosporin antibiotic used in the treatment of meningococcal septicaemia

Question 3

Indications for ceftriaxone

Answer 3

Suspected meningococcal septicaemia with non blanching petechial or purpuric rash

Question 4

Contraindications for ceftriaxone

Answer 4

KSAR to cephalosporin drug

Known anaphylaxis or severe allergic reaction to penicillin based antibiotics

Question 5

Precautions of ceftriaxone

Answer 5

Nil

Question 6

Side effects of ceftriaxone

Answer 6

1. Nausea / vomiting

2. Intense pain at site of injection

Question 7

Presentation of ceftriaxone

Answer 7

1 g vial of powder

Question 8

Onset, duration and half life of ceftriaxone

Answer 8

Onset = 30 secs IVI 60 secs IMI, duration = 5-10 mins, half life = 2 mins

Question 9

Schedule for ceftriaxone

Answer 9

S4 restricted drugs

Question 10

Adult doses for ceftriaxone

Answer 10

IMI 1 g mixed with 3.6 mls of water for injection

IVI 1 g mixed with 9.6 mls of water for injection

Question 11

Paediatric doses for ceftriaxone

Answer 11

IMI all doses mixed with 3.6 mls of water for injection, 50 mg / kg = 0-5 kg 250mg, 5-10kg 500 mg, 10-15 kg 750 mg, >20 kg 1gm
IVI all doses mixed with 9.6 mls of water for injection, 50 mg / kg = 0-5 kg 250mg, 5-10kg 500 mg, 10-15 kg 750 mg, >20 kg 1gm

Question 12

Special notes for ceftriaxone

Answer 12

All cannulae should be flushed with saline following administration