drying Flashcards

1
Q

what is drying?

A

removal of moisture, in particular water by: evapouration/ vaporisation / sublimation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what are the aims of drying?

A
To improve product stability
To improve resuspensionor dissolution
To ensure processability
powder flow
reduced stickiness
Tabletability
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what does the equilibrium pressure- temperature diagram for water show?

A

a graph of pressure vs temp and the requirements for freezing/ evapouration/ sublimination

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

in relative humidity how do air and water behave?

A

Air and water vapourbehave like ideal gases

Air and water are completely miscible

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is the relationship like between the total pressure of air-water vapor mixture and partial pressures of air and vapor?

A

p=pa+pv

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

why is there a restriction for relative humidity at a given temp?

A

at given temperature Pv≤ Ps(Ps: saturation vapour pressure of water)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is the equation for relative humidity?

A

=pv/px X 100%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what is the dew point?

A

it is the cooling of air until pv exceeds ps for a given temp
liquid water will be deposited

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what are the requirements of the psychrometer to measure relative humidity?

A
  • wick must be kept moist

- min air flow velocity of 3m/s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

how do you measure the relative humidity using the psychrometer?

A

measure the difference between the two thermometers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what does an increase in the difference in the psychrometer indicate?

A

The difference increases with decrease in relative humidity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what drying method would you use for a wet particle?

A

convective drying

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what would be an example of convective drying?

A

tray drier

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what would you use for convective drying of wet solids?

A

dynamic fluid bed dryer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

which is better a tray drier or a fluid bed dryer?

A

fluid bed drier-5% moisture content vs 10% for tray drying

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what occurs in convective drying of wet solids heat transfered during fluid bed drying?

A

gas to particle- convective particle
chamber wall to fluid bed- conductive aspect
particle to particle- smaller to coarser particles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what are some of the advantages of fluid bed drying?

A

Eeffective heat and mass transfer
Temperature exposure of temperature labilematerial to heat is minimal
Drying of individual particles
Precise control of bed temperature

18
Q

what are some of the disadvantages of fluid bed drying?

A

Attritiondue to turbulent air flow
Fine particle elutriation
Electrostatic charging
restriction- insufficient fluidisation of particles below 100 or above 1000um

19
Q

what is an example of conductive drying for wet solids?

A

vaccum oven

20
Q

what are some of the advantages of vaccum oven?

A

Drying at low temperatures

Minimum risk of oxidation

21
Q

what are some of the advantages of microwave drying?

A

Rapid drying at low temperatures
High thermal efficiency
Uniform heating of the wet mass
Granulation end point: microwave energy rises when there is little solvent in the wet mass

22
Q

what are some of the disadvantages of microwave drying?

A

Batch size is smaller compared with that of fluid-bed driers
Care: microwave radiation can harm operators

23
Q

what are the applications of drying using fluid bed dryer and vaccuum oven ?

A

analyse drying conditions/ dissolution time/ disintegration time na dtensile strength

24
Q

what affects does drying of pelets have?

A

improve drug dissolution

25
Q

what is freeze drying also known as?

A

lyophilisation

26
Q

what is freeze drying?

A

removal of moistire in particular water by sublimination ( ice- gas without passing through the liquid state)

27
Q

what are the aims of freeze drying?

A

to dry heat sensitive materials without damage e.g.- proteins or blood products

28
Q

what pressure is used in freeze drying?

A

Solid ice maintained below triple point pressure (610 Pa)

29
Q

what occurs in freeze drying?

A

sublimination

30
Q

what are the min freezing temp’s in sublimination?

A

pharmaceutical material :-40–50

biological material -10 to -30

31
Q

what are the 4 stages of the freeze drying process?

A

freezing stage-
vacuum stage
primary drying
secondary drying

32
Q

what happens in the freezing stage?

A

Eutectic formation- not as good freezing

Glass formation- good freezing

33
Q

what is the differnce in primary and secondary drying in the freeze drying process?

A
1= sublimination of ice and vapour removal
2= for bound water desorption
34
Q

what is the residual moisture content for primary freeze drying?

A

about 6%

Hence, secondary drying is required to reduce the residual moisture content to optimum value (<1%

35
Q

what size particles can lyophilisation analyse?what else does it analyse?

A

particles down to nano meters

particle size, zeta potential, and dynamic viscosity

36
Q

what is the cycle summary of freeze drying?

A

During freezing, water crystallises as ice, therefore the concentration of solutes increases and changes the solution from a viscous liquid to a glass
The temperature for this transition is called glass transition temperature (Tg)of the freeze concentrate (Tg) represents the optimal temperaturefor primary drying Secondary drying removes the non-frozenor bound water at elevated temperature
The shelf life of the product depends on the residual moisture content

37
Q

what happens if you go above the critical parameters?

A

T`g
Tcol (collapse temperature)
Tcry (crystallisation temperature)
Teut (eutectic temperature)

38
Q

what kind of stabilising additives do you add to freeze dried products?

A

Sugars: sucrose, trehalose, and lactose
Polyols: glycerol Amino acids: glycine and alanine
Salts: organic or inorganic
Polymers: dextrane, poly vinyl alcoholand carboxymethyl cellulose
Surfactants: Tween 80

39
Q

what are some advantages of freeze drying products?

A

Drying at very low temperatures
Enhancement of product solubility
Preparation of stable pharmaceutical products
No contact with air

40
Q

what are some disadvantages of freeze dry products?

A

Freeze dried products are very hygroscopic
Very slow process
Difficult to control the particle size of the solid

41
Q

what are some of the pharmaceutical applications of freeze drying?

A

Used for drying of heat sensitive products for example: antibiotics, blood products and vaccines
Development of solid protein pharmaceuticals (for long term storage)
Instantaneously dissolving tablets Lyophilised nasal inserts
Drying of micro-and nano-particles

42
Q

what would not be ideal with a freeze dry product?

A

for it to collapse