DRUGSSSS

Question 1

NSAIDS/Salicylates

Answer 1

1st line for self treatment
Mechanism: inhibition of prostaglandin biosynthesis: cox inhibition
ANALGESIC, ANTIPYRETIC, ANTI-INFLA

Question 2

cox 1

Answer 2

normal cells/tissues

expressed in the stomach (protective)

Question 3

Cox 2

Answer 3

induced with inflammation

not expressed in the stomach

Question 4

NSAID adverse reactions

Answer 4

avoid with CV disease/ risk in the elderly
renal insuffiiency/failure
Na/H2O retention/ inc BP
interstitial nephritis
GI bleeding - if cox 1 inhib
Pregnancy - premature closing of ductus arteriosus

Question 5

Liver toxicity signs

Answer 5

flu like Sx
>24 hours - liver pain, renal failure, liver inc
>72 hours jaudice
change in mentation

Question 6

Acetaminophen

Answer 6

TYLENOL; inhibits CNS cyclooxygenase central inhibition of prostaglandins
NOT ANTI-INFLAMMATORY
watch out for OD because in so many OTC drugs

Question 7

Spasmolytics

Answer 7

Skeletal Musc Relaxants
alleviate elevated muscle tone
WATCH OUT: sparing in elderly and CND effects/alcohol effects; some have addictive potential (timmy = must have nicotine)

Question 8

Opiods

Answer 8

Agonist or antagonist with morphine-like activity
agonist - analgesia; no max dose; useful without major side effects
antagonist - reversal of agonist

Question 9

Morphne

Answer 9

Gold Standard Opiod agonist
low bioavailability (25%) half life 3 hrs - always taking it

Question 10

Opiod Adverse Rxn

Answer 10

respiratory depression*
constipation - needs to be addressed with LTerm use
nausea/vomiting
tolerance
neuropsych
myoclonus

Question 11

Fentanyl patch

Answer 11

VERY potent - lasts 72 hours
NOT for acute pain
heating pad will inc _____rate = BAD DONT DO IT

Question 12

Antidepressants/anticonvulsants

Answer 12

chronic - neuropathic pain –> reg NT