Drugs Used in Pituitary and Thyroid Disorders

Question 1

What are the structural and functional units of thyroid gland
?

Answer 1

Thyrocytes or Thyroid follicular cells

Question 2

ER of thyrocyte secretes what molecule?

Answer 2

Thyroglobulin

Question 3

How is Iodide pumped inside cell of thyrocyte?

Answer 3

With the help of Sodium-Iodide symporter

Question 4

How is the Iodide transported into the colloid?

Answer 4

Passively

Question 5

What is the name of the enzyme that helps in oxidization if Iodide into iodine?

Answer 5

Thyroid peroxidase

Question 6

What is the name of the process which involves addition of Iodine to Thyroglobulin molecule ?

Answer 6

Iodination

Question 7

What is the process involved in conversion of T4 to T3?

Answer 7

De-iodination

Question 8

What happens in a hypothyroidism condition?

Answer 8

Elevated levels of TSH and there is no production of T3 and T4

Question 9

What happens in hyperthyroidism?

Answer 9

Elevated levels of T3 & T4 whereas decreased levels of TSH

Question 10

What is graves disease?

Answer 10

Autoantibody production by B cells against the TSH receptors

Question 11

Under which category does PTU and Methimazole fall?

Answer 11

Thioamides class

Question 12

What is the function of PTU and Methimazole?

Answer 12

Inhibits the enzyme Thyroid peroxidase

Question 13

What is the name of another enzyme that is blocked in the periphery by PTU?

Answer 13

5-Deiodinase

Question 14

Drug of choice in hyperthyroidism in 1st trimester?

Answer 14

PTU
Methimazole causes- APLASIS CUTIS in fetus

Question 15

Drug of choice in hyperthyroidism in 2nd trimester?

Answer 15

Methimazole
PTU causes- Hepatotoxicity in fetus

Question 16

Untreated hyperthyroidism with addition of infection state persisting for longer time causes?

Answer 16

Thyroid storm

Question 17

What is the treatment for thyroid storm?

Answer 17

Same as hyperthyroidism with B-blockers like Metoprolol or Propranolol