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FPGEE > Drugs acting on ACTH > Flashcards

Drugs acting on ACTH Flashcards

1
Q

In which part of the adrenal gland ACTH activates and releases cholesterol-side chain cleavage enzyme?

A

Adrenal cortex

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2
Q

Which step does cholesterol side-chain cleavage enzyme catalyze?

A

Cholesterol-Pregnenolone

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3
Q

What is the precursor of all adrenocortical hormones?

A

Pregnenolone

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4
Q

How many zones are present in adrenal cortex layer?

A

3

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5
Q

What hormones does adrenal medulla secrete?

A

Epinephrine and Norepinephrine

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6
Q

What is the secretion from Zona Glomerulosa?

A

Mineralocorticoid (Aldosterone)

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7
Q

What is the secretion from Zona Fasciculata?

A

Glucocorticoid (Cortisol)

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8
Q

What is the secretion from Zona Reticularis?

A

Androgens and Gonad corticoids (Testosterone)

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9
Q

What hormone produces inhibitory effects on Zona Glomerulosa?

A

Anti natriuretic peptide

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10
Q

What hormones plays a major role in sodium and water reabsorption in the body?

A

Aldosterone

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11
Q

Which hormone increases the overall blood volume, blood pressure and causes hypernatriamia?

A

Aldosterone

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12
Q

Which hormone is referred to as stress hormone?

A

Cortisol

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13
Q

Which hormone suppress immune system by releasing cytokines?

A

Cortisol

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14
Q

Which hormone breaks down proteins into amino acids?

A

Cortisol

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15
Q

Which hormone can upregulate and downregulate its quantity in blood?

A

Cortisol

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16
Q

Which disease is associated with decreased secretion of cortisol and aldosterone?

A

Addison’s disease (insufficiency of adrenocortical hormones)

17
Q

What drugs are used in the treatment of Addison’s disease?

A

Fludrocortisone
Hydrocortisone/Prednisone

18
Q

What disease is associated with increased secretion of cortisol?

A

Cushing’s syndrome

19
Q

What are used in treating Cushing’s syndrome?

A

Stopping corticosteroid hormone

20
Q

What is the treatment of choice in adrenal tumor?

A

Ketoconazole, Metyrapone, Mitotane

FPGEE (11 decks)

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