Drugs used in labour Flashcards
2 roles of oxytocin in labour and delivery
ripening of the cervix
contractions of the uterus
an oxytocin antagonist
atosiban (used for tocolysis)
what is the MOA of ergometrine?
contraction of smooth muscle
In which stages are these medications used?
Ergometrine
Syntocinon
Third stage
Early stages
Adverse Effects of ergometrine (4)
diarrhoea
HTN
angina
vomiting
(because it causes contraction of smooth muscle)
when to avoid giving ergometrine
in eclampsia (completely contra-indicated)
in HTN
which prostaglandin analogue is used for induction of labour?
which prostaglandin analogue is used for management of IUFD, miscarriage and termination?
dinoprostone
misoprostol
what type of prostaglandin is dinoprostone?
E2
what is the MOA of terbinafine?
beta-2 agonist
tocolysis by inhibiting smooth muscle contraction
what is carboprost used for?
how is it given?
it is used for PPH when syntometrine has failed
it is given as a deep intramuscular injection
what is the major contraindication to carboprost?
it can cause life-threatening exacerbations of asthma
what is the MOA of tranexamic acid?
fibrinolytic
