Acute fatty liver (in pregnancy)

Question 1

what is the basic pathophysiology of acute fatty liver of pregnancy?

Answer 1

failure of the placenta to break down circulating fats, resulting in accumulation in the liver and acute liver failure

Question 2

most common genetic condition which would lead to acute fatty liver of pregnancy

what is the inheritance pattern?

Answer 2

long-chain-3-hydroxyacyl-CoA dehydrogenase deficiency (LCHAD deficiency) in the feotus

AR

Question 3

6 presenting symptoms of acute fatty liver of pregnancy

Answer 3

symptoms of liver failure i.e.

abdo pain
ascites
fatigue
anorexia
jaundice
N+V

Question 4

bloods in acute fatty liver of pregnancy will show… (2)

Answer 4

liver failure

inflammation

Question 5

what is the management of acute fatty liver of pregnancy?

Answer 5

prompt delivery of the baby (NB it presents in the 3rd trimester)

management of acute liver failure if it occurs
——> consider transplant