Drugs of Abuse

Question 1

Naltrexone

Answer 1

MOA: opioid antagonist

USE: chronic alc, decrease reward feeling/craving

AE:
-Nausea
-Hepatoxicity

Question 2

Acamprosate

Answer 2

MOA: GABAa activator

USE: chronic alc, decrease need/sx

AE: AIDDD
-CNS (anxiety/dep/diz/insomnia)
-Diarrhea

Question 3

Disulfiram

Answer 3

MOA: suicide inhibitor, acetaldehyde syndrome

USE: chronic alc

AE:
-Flushing
-HA/N/V
-Hypotension (with ethanol)

Precaution:
-Disguised forms of alcohol: fermented vinegar, cough syrups, sauces

Question 4

Naloxone has poor oral/sublingual bioavailability (extensive ____) but blocks effects of buprenorphine if buprenorphine + naloxone combination is administered ___

Answer 4

extensive first-pass metabolism in liver
administered IV

Question 5

Nicotine

Answer 5

MOA: nAChR agonist

USE: manage smoking cessation

AE:
-Headache
-Appetite stimulatioin

Question 6

Varenicline

Answer 6

MOA: nAChR agonist

USE: manage smoking cessation

AE: NASH
-Nausea
-Sleep disturbances
-Abnormal dreams
-Headache

Question 7

Bupropion

Answer 7

MOA: inhibits NE/DA

USE: depression, smoking cessation

AE:
-Insomnia
-Xero
-HA
-Agitation
-Anxiety

Contra: seizures